Abstract：
:Arylomycins are type I signal peptidase inhibitors and have a potential as a new type of antibiotics. They were identified from the broth of Streptomyces sp. HCCB10043. The arylomycin biosynthetic gene cluster in this strain was identical to that in S. roseosporus. Within the gene cluster, aryC, encoding a P450 enzyme, was deduced to be responsible for biaryl bond formation in, the arylomycins. Inactivation of aryC abolished arylomycin production and led to the generation of two novel linear lipopentapeptides lacking the aryl-aryl linkage. These derivatives had lost their antibacterial activities against Staphylococcus epidermidis which is sensitive to arylomycins A2 and A4.
journal_name
Biotechnol Lettjournal_title
Biotechnology lettersauthors
Jin X,Rao M,Wei W,Ge M,Liu J,Chen D,Liang Ydoi
10.1007/s10529-012-1032-2subject
Has Abstractpub_date
2012-12-01 00:00:00pages
2283-9issue
12eissn
0141-5492issn
1573-6776journal_volume
34pub_type
杂志文章abstract：:A gene encoding a gamma-butyrolactone autoregulator receptor was cloned in to E. coli from Streptomyces ambofaciens producing spiramycin, a macrolide antibiotic used in both veterinary medicine and human medicine. A 714-bp intact receptor gene (saaR) was obtained by PCR and genomic Southern hybridization with the 100-...
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journal_title：Biotechnology letters
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journal_title：Biotechnology letters
pub_type： 杂志文章
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journal_title：Biotechnology letters
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journal_title：Biotechnology letters
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journal_title：Biotechnology letters
pub_type： 杂志文章
doi：10.1007/s10529-006-9129-0
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journal_title：Biotechnology letters
pub_type： 杂志文章
doi：10.1007/s10529-015-1957-3
更新日期：2016-01-01 00:00:00
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journal_title：Biotechnology letters
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pub_type： 杂志文章
doi：10.1007/s10529-013-1335-y
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pub_type： 杂志文章
doi：10.1007/s10529-004-3185-0
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abstract：:The exploded bast, branch and stem of cotton stalk were degraded by alkalophilic Bacillus NT-19, with weight losses of 24%, 20% and 14%, respectively, after 14 d. Compared with a white-rot fungus (Phanerochaete chrysosporium), Bacillus NT- 19 preferentially degraded the non-cellulose components of cotton stem. The rel...
journal_title：Biotechnology letters
pub_type： 杂志文章
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更新日期：2003-09-01 00:00:00
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journal_title：Biotechnology letters
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更新日期：2003-04-01 00:00:00
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journal_title：Biotechnology letters
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Biotechnology letters
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Biotechnology letters
pub_type： 杂志文章
doi：10.1023/a:1023584805911
更新日期：2003-05-01 00:00:00
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journal_title：Biotechnology letters
pub_type： 杂志文章
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journal_title：Biotechnology letters
pub_type： 杂志文章
doi：10.1007/s10529-010-0284-y
更新日期：2010-09-01 00:00:00
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journal_title：Biotechnology letters
pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
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journal_title：Biotechnology letters
pub_type： 杂志文章
doi：10.1007/s10529-014-1730-z
更新日期：2015-03-01 00:00:00
