Nucleotide sequence and deletion analysis of the polB gene of Escherichia coli.

abstract：:The gene for the bovine oxytocin receptor has been sequenced using a combination of clones derived from a bovine endometrial cDNA library from estrus and a bovine genomic DNA library, with confirmation of structure using reverse transcription PCR programmed by term myometrial RNA. The receptor belongs to the seven tra...

journal_title：DNA and cell biology

authors： Bathgate R,Rust W,Balvers M,Hartung S,Morley S,Ivell R

更新日期：1995-12-01 00:00:00

abstract：:The function of retinoic acid-inducible gene-I (RIG-I) in viral replication is well documented, but its function in carcinogenesis and malignancies as well as relationship with microRNAs (miRNAs) remain poorly understood. miR-34a is an antioncogene in multiple tumors. In our study, RIG-I and miR-34a suppressed cell gr...

journal_title：DNA and cell biology

authors： Wang JH,Zhang L,Ma YW,Xiao J,Zhang Y,Liu M,Tang H

更新日期：2016-06-01 00:00:00

abstract：:The epidermal growth factor (EGF) pathway stimulates proliferation and differentiation of epidermal and epithelial tissues, and plays an important role in tumorigenesis. The association between EGF polymorphisms and cancer risk is controversial; thus, we performed this meta-analysis. Overall, 41 case-control studies w...

journal_title：DNA and cell biology

authors： Li TF,Ren KW,Liu PF

更新日期：2012-04-01 00:00:00

abstract：:The aim of this work was to express a eukaryotic pre-protein in Escherichia coli so that it could be obtained intact, without cleavage, by bacterial leader peptidase. To this end, cDNA coding for honeybee prepromelittin was ligated to the 3' end of genes coding for truncated forms of either Protein A or beta-galactosi...

journal_title：DNA and cell biology

authors： He M,Liu H,Austen B

更新日期：1994-08-01 00:00:00

abstract：:We describe a new vector system that allows efficient expression of heterologous proteins in transformed mouse L fibroblasts. This is due to its persistence at high copy numbers, achieved by a 370-bp amplification promoting element (muNTS1) derived from the nontranscribed spacer of murine rDNA. Copy number determinati...

journal_title：DNA and cell biology

authors： Hemann C,Gärtner E,Weidle UH,Grummt F

更新日期：1994-04-01 00:00:00

abstract：PURPOSE:This case-control study was conducted in order to evaluate the potential role of polymorphic genes encoding enzymes involved in estrogen biosynthesis (CYP19A1) and metabolism (GSTM1, GSTT1, and GSTP1), and their action in modulating individual susceptibility to breast cancer. METHODS:Genomic DNA was extracted ...

journal_title：DNA and cell biology

authors： Ramalhinho AC,Fonseca-Moutinho JA,Breitenfeld Granadeiro LA

更新日期：2012-06-01 00:00:00

abstract：:Acetate and β-hydroxybutyrate (BHBA) are the predominant substrates for de novo fatty acid (FA) synthesis in mammary gland of dairy cow. To investigate the nutrigenomic role of acetate and BHBA in bovine mammary epithelial cells during milk fat production, RNA sequencing (RNA-seq) transcriptomic analysis was used to i...

journal_title：DNA and cell biology

authors： Song S,Jiang M,Zhou J,Zhao F,Hou X,Lin Y

更新日期：2020-03-01 00:00:00

abstract：:Screening of a mouse kidney cDNA library with a HNF-3/fork head domain probe revealed cDNA Hfh-1L containing the highly conserved fork head DNA-binding domain. The Hfh1L cDNA shows 92.7% homology at the nucleic acid level with the fork head gene HFH-1 from rat. Southern blot analyses demonstrated that the Hfh-1L gene ...

journal_title：DNA and cell biology

authors： Frank S,Zoll B

更新日期：1998-08-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic and debilitating autoimmune disorder of the central nervous system in which the autoimmune T cells destroy myelin, thus causing lesion, damage, and neuronal dysfunction. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that is particularly useful for testing...

journal_title：DNA and cell biology

authors： Pahan S,Pahan K

更新日期：2019-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a life-threatening disease that is often associated with chronic infection by hepatitis B and C viruses. Genetic polymorphisms have been reported to alter the risk for HCC development. Genetic studies based on the haplotype have an increased power for detecting disease associations co...

journal_title：DNA and cell biology

authors： Kiran M,Chawla YK,Jain M,Kaur J

更新日期：2009-11-01 00:00:00

abstract：:A nomenclature system for the UDP glucuronosyltransferase superfamily is proposed, based on divergent evolution of the genes. A total of 26 distinct cDNAs in five mammalian species have been sequenced to date. Comparison of the deduced amino acid sequences leads to the definition of two families and a total of three s...

journal_title：DNA and cell biology

authors： Burchell B,Nebert DW,Nelson DR,Bock KW,Iyanagi T,Jansen PL,Lancet D,Mulder GJ,Chowdhury JR,Siest G

更新日期：1991-09-01 00:00:00

abstract：:Uridine diphosphate glucuronosyltransferases (UGTs) are important phase II detoxification enzymes. Despite the expression of UGT proteins in many species, previous results have suggested that simians represent the most appropriate animal model to study the glucuronidation of steroids in extrahepatic steroid target tis...

journal_title：DNA and cell biology

authors： Bélanger G,Beaulieu M,Lévesque E,Hum DW,Bélanger A

更新日期：1997-10-01 00:00:00

abstract：:At supramolecular resolution, DNA synthesis begins at preferred replication origins in the chromosomes of metazoan cells. To characterize one of these origins in detail, the initiation of replication was examined in the HeLa c-myc origin. Polymerase chain reaction (PCR) amplification of size-fractionated nascent chrom...

journal_title：DNA and cell biology

authors： Trivedi A,Waltz SE,Kamath S,Leffak M

更新日期：1998-10-01 00:00:00

abstract：:Peroxisomes are membrane-bound organelles that are best known for their roles in lipid metabolism. Mounting evidence indicates that they are also important nodes for antiviral signaling. While research over the past few decades has revealed effective viral strategies to block antiviral signalling pathways from the pla...

journal_title：DNA and cell biology

authors： Wong CP,Xu Z,Power C,Hobman TC

更新日期：2018-05-01 00:00:00

abstract：:Heme plays a significant pathogenic role in several diseases involving the kidney. The cellular content of heme, derived either from the delivery of filtered heme proteins such as hemoglobin and myoglobin, or from the breakdown of ubiquitous intracellular heme proteins, is regulated via the heme oxygenase enzyme syste...

journal_title：DNA and cell biology

authors： Hill-Kapturczak N,Chang SH,Agarwal A

更新日期：2002-04-01 00:00:00

abstract：:Congenital cataract refers to a lens opacity caused by multiple etiological factors, including genetic mutation, abnormal metabolism of the lens, and infection. Currently, there are >100 known disease-causing genes as well as 60 known mutations in the Cx46 gene (Gap junction alpha-3, GJA3) associated with congenital c...

journal_title：DNA and cell biology

authors： Li H,Jiang H,Rong R,Jiang J,Ji D,Song W,Xia X

更新日期：2020-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by overproduction of beta-amyloid (Abeta), which is formed from amyloid precursor protein (APP), with the subsequent pathologic deposition of Abeta in regions of the brain important for memory and cognition. Recently, vaccination of murine models o...

journal_title：DNA and cell biology

authors： Dickey CA,Morgan DG,Kudchodkar S,Weiner DB,Bai Y,Cao C,Gordon MN,Ugen KE

更新日期：2001-11-01 00:00:00

abstract：:Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy worldwide. Interleukin-2 (IL-2) plays a key role in the proliferation of T cells and natural killer cells. It has been reported that polymorphisms in the IL-2 gene are associated with various cancers. The aim of this study was to examine the effect o...

journal_title：DNA and cell biology

authors： Song H,Chen L,Cha Z,Bai J

更新日期：2012-07-01 00:00:00

abstract：:Promoter elements located up to 2 kb upstream of the apolipoprotein A-I (apoA-I) gene are necessary for apoA-I expression in liver and intestine cells in tissue culture. In transgenic mice, a distal enhancer located between the apoA-IV and apoC-III genes is additionally necessary for tissue-specific expression of apoA...

journal_title：DNA and cell biology

authors： Jones DR,Leffak M

更新日期：1999-02-01 00:00:00

abstract：:The potential association of variant surface glycoprotein (VSG) gene expression with clonal expression of virulence in African trypanosomes was addressed. Two populations of clonally related trypanosomes, which differ dramatically in virulence for the infected host, but display the same apparent VSG surface coat pheno...

journal_title：DNA and cell biology

authors： Inverso JA,Uphoff TS,Johnson SC,Paulnock DM,Mansfield JM

更新日期：2010-05-01 00:00:00

abstract：:The breast cancer gene 1 (BRCA1) is a tumor suppressor, and mutations or epigenetic inactivation will increase the risk of breast cancer oncogenesis. The current research aimed to explore the relationship between BRCA1 expression, prognosis, and tumor immunity in hepatocellular carcinoma (HCC). In this study, BRCA1 ex...

journal_title：DNA and cell biology

authors： Mei J,Wang R,Xia D,Yang X,Zhou W,Wang H,Liu C

更新日期：2020-10-01 00:00:00

abstract：:The human spermidine synthase (EC 2.5.1.16) gene was isolated from a genomic library constructed with DNA obtained from a human immunoglobulin G (IgG) myeloma cell line. Subsequent sequence analyses revealed that the gene comprised of 5,818 nucleotides from the cap site to the last A of the putative polyadenylation si...

journal_title：DNA and cell biology

authors： Myöhänen S,Kauppinen L,Wahlfors J,Alhonen L,Jänne J

更新日期：1991-07-01 00:00:00

abstract：:Among environmental pollutants, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is one of the most potent tumor promoters and teratogens known. The molecular mechanisms responsible for the biological activity of TCDD, however, remain largely unknown. In this report, we show that the first observable effects of TCDD...

journal_title：DNA and cell biology

authors： Puga A,Nebert DW,Carrier F

更新日期：1992-05-01 00:00:00

abstract：:It is well known that the positively charged polyamines have a DNA-stabilizing function and that polyamine depletion alters chromatin function. We have previously shown that polyamine depletion causes an S phase prolongation, and others have shown that there is an accumulation of Okazaki-like fragments in polyamine-de...

journal_title：DNA and cell biology

authors： Johansson VM,Oredsson SM,Alm K

更新日期：2008-09-01 00:00:00

abstract：:The impact of chromatin topology on the DNA synthetic process was studied in the human squamous-cell carcinoma cell line SQ-20B. A 1-h exposure < or = 10 microM VP16 produced an increase in DNA supercoil tension, measured by recording laser light scatter from salt-extracted nuclei. This change was precisely paralleled...

journal_title：DNA and cell biology

authors： Narayana A,Khodarev N,Walter S,Vaughan AT

更新日期：1998-07-01 00:00:00

abstract：:A decrease in gap junctional, intercellular communication (GJIC) has been associated with cells neoplastically transformed by a variety of factors. To investigate the role of the Ras oncogene product in gap junction function, a panel of murine C3H10T1/2 (10T1/2) fibroblasts was constructed in which the levels of ras g...

journal_title：DNA and cell biology

authors： Brownell HL,Narsimhan RP,Corbley MJ,Mann VM,Whitfield JF,Raptis L

更新日期：1996-06-01 00:00:00

abstract：:Several reports have suggested the importance of p73 polymorphisms in tumor behavior. We investigated the role of a p73 gene polymorphism in the susceptibility to cervical lesions in a southwestern European population. Peripheral blood samples were obtained from Radiotherapy and Gynaecology Departments of Portuguese I...

journal_title：DNA and cell biology

authors： Craveiro R,Bravo I,Catarino R,Teixeira AL,Sousa H,Pereira D,Pereira H,Medeiros R

更新日期：2012-02-01 00:00:00

abstract：:The abnormal function of O(6)-methylguanine-DNA methyltransferase (MGMT) is reported to be associated with the occurrence of various tumors and malignant tumor progression. However, little evidence is available to describe its role in esophageal carcinogenesis. To address this issue, we constructed a stable MGMT-silen...

journal_title：DNA and cell biology

authors： Su Y,Liu R,Sheng J,Liu H,Wang Y,Pan E,Guo W,Pu Y,Zhang J,Liang G,Tang D,Yin L

更新日期：2012-05-01 00:00:00

abstract：:Global antibiotic resistance, driven by intensive antibiotic exposure/abuse, constitutes a serious challenge to all health care, particularly in an era when new antimicrobial development has slowed to a trickle. Recently, we published work demonstrating the discovery and partial mechanism of action of a novel bacteric...

journal_title：DNA and cell biology

authors： Hassett DJ,Meyer TJ

更新日期：2020-09-01 00:00:00

abstract：:Minimally modified low-density lipoprotein (MM-LDL) is regarded as a major risk factor for the development of atherosclerosis. In this report, we show that this lipoprotein complex can induce expression of an inflammatory protein, serum amyloid A (SAA), in monocyte/macrophage cells, a key cell type implicated in the p...

journal_title：DNA and cell biology

authors： Ray BK,Chatterjee S,Ray A

更新日期：1999-01-01 00:00:00