Meta-analysis of epidermal growth factor polymorphisms and cancer risk: involving 9,779 cases and 15,932 controls.

abstract：:The spike (S) protein, a main surface antigen of the SARS coronavirus (SARS-CoV), is considered to be one of the most important protective antigen candidates for targets for vaccine design against the virus. In this study, a secreted recombinant expression plasmid, pVAX-S1, encoding the partial S protein with a signal...

journal_title：DNA and cell biology

authors： He H,Tang Y,Qin X,Xu W,Wang Y,Liu X,Liu X,Xiong S,Li J,Zhang M,Duan M

更新日期：2005-08-01 00:00:00

abstract：:An increasing amount of evidence suggests that interleukin-18 (IL-18) plays a pivotal role in the pathophysiology of schizophrenia. However, association between single nucleotide polymorphism of IL-18 and the risk of schizophrenia has not been clarified. This study examined whether two promoter polymorphisms -137 G/C ...

journal_title：DNA and cell biology

authors： Liu J,Liu J,Zhou Y,Li S,Li Y,Song X,Wang J,Wang L,Ying B

更新日期：2011-11-01 00:00:00

abstract：:KCNQ1 overlapping transcript 1 (KCNQ1OT1), a long noncoding RNA responsible for silencing a cluster of genes in cis, has been shown to be involved in multiple cancers. However, much remains unclear of how KCNQ1OT1 contributes to carcinogenesis. By thoroughly analyzing 510 hepatocellular carcinoma (HCC) cases and 1014 ...

journal_title：DNA and cell biology

authors： Wan J,Huang M,Zhao H,Wang C,Zhao X,Jiang X,Bian S,He Y,Gao Y

更新日期：2013-11-01 00:00:00

abstract：:Epidemiological evidence on the relationship between IL1A and/or IL1B polymorphisms and periodontal disease is inconsistent. We investigated associations between three IL1 single-nucleotide polymorphisms (SNPs) in genes encoding interleukin (IL) -1α (rs1800587) and IL-1β (rs1143634 and rs16944) and the risk of periodo...

journal_title：DNA and cell biology

authors： Tanaka K,Miyake Y,Hanioka T,Arakawa M

更新日期：2014-04-01 00:00:00

abstract：:Gene expression is modulated by epigenetic factors that come in varying forms, such as DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent studies reveal that these epigenetic marks are important regulatory factors in brain function. In particular, DNA methylation dynamics are found to b...

journal_title：DNA and cell biology

authors： Irier HA,Jin P

更新日期：2012-10-01 00:00:00

abstract：:The application of endogenous regeneration in regenerative medicine is based on the concept of inducing regeneration of damaged or lost tissues from residual tissues in situ. Therefore, endogenous regeneration is also termed in vivo regeneration as opposed to mechanisms of ex vivo regeneration which are applied, for e...

journal_title：DNA and cell biology

authors： Löwenheim H

更新日期：2003-09-01 00:00:00

abstract：:The globally distributed American cockroach (Periplaneta americana) is considered a pest, but it has been widely used in traditional Chinese medicine. In the past, the American cockroach's genome and transcriptomes were sequenced, but the differential expression transcripts between developmental stages were unavailabl...

journal_title：DNA and cell biology

authors： Zeng C,Li W,Liao Q,Yan T,Wang K,Hu Y,Shen Y,Price M,Fan Z,Zhang X,Yue B,Geng F,Chen L

更新日期：2019-10-01 00:00:00

abstract：:Most studies on the tissue distribution of actin isoform transcripts have been done in small mammals such as rat and mouse. We have begun a characterization of the actin gene family in a large mammal, the bovine. The alpha skeletal gene was isolated, and an isoform-specific probe to the 3' untranslated region of the t...

journal_title：DNA and cell biology

authors： Davey HW,Wildeman AG

更新日期：1995-06-01 00:00:00

abstract：:Cytochrome P450c17 catalyzes the 17alpha-hydroxylase/17,20 lyase activity needed for sex steroid synthesis. We recently characterized the nuclear phosphoprotein SET as a novel transcriptional regulator that binds to the -447/-399 region of the rat P450c17 gene, along with the transcription factors COUP-TF II, NGF-IB, ...

journal_title：DNA and cell biology

authors： Zhang P,Compagnone NA,Fiore C,Vigne JL,Culp P,Musci TJ,Mellon SH

更新日期：2001-10-01 00:00:00

abstract：:The aim of this work was to express a eukaryotic pre-protein in Escherichia coli so that it could be obtained intact, without cleavage, by bacterial leader peptidase. To this end, cDNA coding for honeybee prepromelittin was ligated to the 3' end of genes coding for truncated forms of either Protein A or beta-galactosi...

journal_title：DNA and cell biology

authors： He M,Liu H,Austen B

更新日期：1994-08-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) is known for its ability to infect immune cells, including T-cells and macrophages. The 96-amino acid Vpr, a virion-associated protein, is essential for viral replication in monocytes/macrophages and increases viral replication in primary and established T-cell lines. The Vp...

journal_title：DNA and cell biology

authors： Muthumani K,Montaner LJ,Ayyavoo V,Weiner DB

更新日期：2000-03-01 00:00:00

abstract：:We describe a new vector system that allows efficient expression of heterologous proteins in transformed mouse L fibroblasts. This is due to its persistence at high copy numbers, achieved by a 370-bp amplification promoting element (muNTS1) derived from the nontranscribed spacer of murine rDNA. Copy number determinati...

journal_title：DNA and cell biology

authors： Hemann C,Gärtner E,Weidle UH,Grummt F

更新日期：1994-04-01 00:00:00

abstract：:This research aims to investigate the immune-associated gene signature from databases to improve the prognostic value in hepatocellular carcinoma (HCC) by multidimensional methods using various bioinformatic methods. Fifty-one immune-associated genes were mined out, which were associated with clinical characters throu...

journal_title：DNA and cell biology

authors： Chen W,Tang D,Ou M,Dai Y

更新日期：2020-04-01 00:00:00

abstract：:Denaturing gradient gel electrophoresis (DGGE) was used to examine error rates and mutations induced by native (wt) and exonuclease-deficient (exo-) Deep Vent DNA polymerases during DNA amplification by polymerase chain reaction (PCR), in the presence or absence of the T4 bacteriophage gene 32 protein (gp32).gp32 was ...

journal_title：DNA and cell biology

authors： Huang H,Keohavong P

更新日期：1996-07-01 00:00:00

abstract：:Long noncoding RNA host gene 16 (SNHG16) has a key role in a variety of cancer progression. However, the role and mechanism of SNHG16 in osteosarcoma (OS) remain unknown. In this study, we examined the functional role of SNHG16 in OS cells through knocked-down SNHG16 by using siRNA. We found that SNHG16 is overexpress...

journal_title：DNA and cell biology

authors： Su P,Mu S,Wang Z

更新日期：2019-02-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) refers to breast cancer without significant expression of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2. We sought to identify the hub genes and find the potential progression mechanism of TNBC as well as immunotherapeutic targets. ...

journal_title：DNA and cell biology

authors： Wang F,Cao X,Yin L,Wang Q,He Z

更新日期：2020-10-01 00:00:00

abstract：:Zidovudine (AZT) is widely used in the treatment of human immunodeficiency virus (HIV) infection because of its ability to act as a false substrate for the viral reverse transcriptase. AZT in the clinical setting has also been shown to produce significant hematologic and other toxicity, even though prior reports in th...

journal_title：DNA and cell biology

authors： Nusbaum NJ,Joseph PE

更新日期：1996-05-01 00:00:00

abstract：:The amino acid sequences directing the nuclear transport of the RNA polymerase I transcription factor xUBF have been studied by a novel combination of in oocyte-coupled translation-nuclear transport and selective HCl extraction. Synthetic mRNA was used to direct the translation of labeled xUBF and its mutants in micro...

journal_title：DNA and cell biology

authors： Dimitrov SI,Bachvarov D,Moss T

更新日期：1993-04-01 00:00:00

abstract：:Mouse vimentin intermediate filaments (IFs) reconstituted in vitro were analyzed for their capacity to select certain DNA sequences from a mixture of about 500-bp-long fragments of total mouse genomic DNA. The fragments preferentially bound by the IFs and enriched by several cycles of affinity binding and polymerase c...

journal_title：DNA and cell biology

authors： Wang X,Tolstonog G,Shoeman RL,Traub P

更新日期：1996-03-01 00:00:00

abstract：:Ulcerative colitis (UC) is a long-time inflammatory condition arising from aberrant immune activation in the colon and the rectum. Interleukin (IL)-35 plays critical roles in autoimmune disorders. In this study, we explored the pathways of IL-35 in affecting UC. First, peripheral blood mononuclear cells (PBMCs) from U...

journal_title：DNA and cell biology

authors： Wang S,Qin C

更新日期：2017-05-01 00:00:00

abstract：:Cytochrome P450 15 beta is a female-specific gene product that catalyzes the hydroxylation of steroid sulfates at the 15 beta position. Isolation and analysis of the gene for rat P450 15 beta reveals nine coding exons and encompasses more than 35 kb of chromosomal DNA. The intron-exon junctions are at similar position...

journal_title：DNA and cell biology

authors： Zaphiropoulos PG,Westin S,Ström A,Mode A,Gustafsson JA

更新日期：1990-01-01 00:00:00

abstract：:The human spermidine synthase (EC 2.5.1.16) gene was isolated from a genomic library constructed with DNA obtained from a human immunoglobulin G (IgG) myeloma cell line. Subsequent sequence analyses revealed that the gene comprised of 5,818 nucleotides from the cap site to the last A of the putative polyadenylation si...

journal_title：DNA and cell biology

authors： Myöhänen S,Kauppinen L,Wahlfors J,Alhonen L,Jänne J

更新日期：1991-07-01 00:00:00

abstract：:Diabetes is a worldwide health problem with increasing prevalence. Some reports indicate the interplay between bone and glucose metabolism. The imbalance between bone resorption and formation resulted in the structural integrity and strength of bone. Glucagon-like peptide-1 (GLP-1) and its agonists (Liraglutide) have ...

journal_title：DNA and cell biology

authors： Gao L,Li SL,Li YK

更新日期：2018-12-01 00:00:00

abstract：:A highly conserved aspartic acid residue present in the third membrane-spanning region of adrenergic and muscarinic receptors is directly involved in ligand binding. The five cloned somatostatin receptor subtypes also contain this residue at the same relative position. To test whether Asp-124 of the rat somatostatin r...

journal_title：DNA and cell biology

authors： Nehring RB,Meyerhof W,Richter D

更新日期：1995-11-01 00:00:00

abstract：:Six identical cDNA clones corresponding to an RNA of 1685 nucleotides that is enriched in mouse sperm compared with testis were isolated from a mouse testis cDNA library. The sequence of these clones corresponds to the 16S mitochondrial RNA plus an inverted repeat of 120 bp covalently joined to the 5' end of the RNA. ...

journal_title：DNA and cell biology

authors： Villegas J,Zárraga AM,Muller I,Montecinos L,Werner E,Brito M,Meneses AM,Burzio LO

更新日期：2000-09-01 00:00:00

abstract：:Growth factors are important mediators of proliferation. Deregulation in growth factor mechanisms as well as in its receptors will contribute to cancer development. One of the most important is the epidermal growth factor (EGF), which is encoded by EGF gene. A functional polymorphism at position 61 (A/G) is associated...

journal_title：DNA and cell biology

authors： Araújo AP,Ribeiro R,Pinto D,Pereira D,Sousa B,Mauricio J,Lopes C,Medeiros R

更新日期：2009-05-01 00:00:00

abstract：:Fibulin-5 (FBLN-5) is a widely expressed, integrin-binding extracellular matrix protein that mediates endothelial cell adhesion and scaffolds cells to elastic fibers. It is also a gene target of TGF-beta in fibroblasts and endothelial cells that regulates cell proliferation and motility in a context-specific manner. W...

journal_title：DNA and cell biology

authors： Albig AR,Schiemann WP

更新日期：2004-06-01 00:00:00

abstract：:The polB gene encodes DNA polymerase II in Escherichia coli. The nucleotide sequence shows an open reading frame of 2,304 nucleotides coding for a protein of 88 kD. The protein initiation signal is preceded by a lexA box lying 2 nucleotides from the termination signal of araD, and begins with GUG 75 nucleotides after ...

journal_title：DNA and cell biology

authors： Chen H,Sun Y,Stark T,Beattie W,Moses RE

更新日期：1990-11-01 00:00:00

abstract：:Voltage-gated potassium channels play important functional roles in the development and maintenance of human lymphocyte functions. One such channel, known as the type n channel, has been well defined in human T cells and exhibits unique functional properties that distinguish it from other species of potassium channels...

journal_title：DNA and cell biology

authors： Cai YC,Osborne PB,North RA,Dooley DC,Douglass J

更新日期：1992-03-01 00:00:00

abstract：:Eaf2 encodes a tumor suppressor that plays multiple functions in transcriptional activation, apoptosis, and embryonic development. In this study, we utilized GFP-EAF2 fusion protein to describe the dynamic subcellular movement of Eaf2. GFP-EAF2 is preferentially localized to the nucleus, and in the presence of ELL, it...

journal_title：DNA and cell biology

authors： Zhuang F,Yen P,Zhao J,Nguyen M,Jiang M,Liu YH

更新日期：2008-12-01 00:00:00