microRNA-34a-Upregulated Retinoic Acid-Inducible Gene-I Promotes Apoptosis and Delays Cell Cycle Transition in Cervical Cancer Cells.

abstract：:The ras oncogene exists in a variety of human cancers, including carcinomas of bladder, breast, colon, kidney, liver, lung, ovary, pancreas, and stomach. The ras genes acquire transforming activity either by enhanced expression or by a single point mutation. A single base-pair mutation at specific sites within ras gen...

journal_title：DNA and cell biology

authors： Chien CH,Chow SN

更新日期：1993-09-01 00:00:00

abstract：:Porifera (sponges) constitute the lowest metazoan phylum. Experiments examined whether sponges can recognize self/nonself molecules. Cells from the marine sponge Suberites domuncula were incubated with membranes from either S. domuncula or another marine sponge, Geodia cydonium, as well as with recombinant alpha-integ...

journal_title：DNA and cell biology

authors： Müller WE,Perovic S,Wilkesman J,Kruse M,Müller IM,Batel R

更新日期：1999-12-01 00:00:00

abstract：:Epidemiological evidence on the relationship between IL1A and/or IL1B polymorphisms and periodontal disease is inconsistent. We investigated associations between three IL1 single-nucleotide polymorphisms (SNPs) in genes encoding interleukin (IL) -1α (rs1800587) and IL-1β (rs1143634 and rs16944) and the risk of periodo...

journal_title：DNA and cell biology

authors： Tanaka K,Miyake Y,Hanioka T,Arakawa M

更新日期：2014-04-01 00:00:00

abstract：:Chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing protein 6 (CMTM6) is a ubiquitously expressed protein, which plays a critical role in the stability of programmed death-ligand 1. However, the expression of CMTM6 in a variety of cancer pathological tissues is not clear. Therefore, 109 patients w...

journal_title：DNA and cell biology

authors： Hou X,He S,Zhang D,Yang C,Shi Y,Zhang K

更新日期：2020-10-21 00:00:00

abstract：:The prototypic member of the transforming growth factor beta family is TGFbeta1, which is known to be important in extracellular matrix production, cell proliferation, and cell differentiation. Specifically in the pituitary lactotroph, TGFbeta1 inhibits prolactin (PRL) peptide secretion, PRL mRNA levels, and PRL gene ...

journal_title：DNA and cell biology

authors： Farrow KN,Gutierrez-Hartmann A

更新日期：1999-11-01 00:00:00

abstract：:The CAT gene is widely used as a reporter in eukaryotic systems because of the efficient translation of its mRNA. We report here that a sequence occurring in the CAT mRNA at +15 nucleotides from CAT AUG is essential for translation. This sequence includes a stem-loop structure, which, however, exhibits a calculated st...

journal_title：DNA and cell biology

authors： Ciullo M,Del Pozzo G,Autiero M,Guardiola J

更新日期：2000-01-01 00:00:00

abstract：:Chlamydial infection of the lower genital tract usually spreads to the upper genital tract and is then responsible for more serious consequences, such as infertility, ectopic pregnancy, pelvic pain, and pelvic inflammatory disease. Genital infection with Chlamydia trachomatis and the resulting cytokine response largel...

journal_title：DNA and cell biology

authors： Srivastava P,Bhengraj AR,Jha HC,Vardhan H,Jha R,Singh LC,Salhan S,Mittal A

更新日期：2012-03-01 00:00:00

abstract：:The serotonin (5-hydroxytryptamine) transporter (5HTt) gene has been reported to be associated with suicidal behavior. In this study, we have investigated the 5' promoter region (i.e., 5HTt gene-linked polymorphic region [5-HTTLPR]) and a 17-base pair variable number of tandem repeats polymorphism in the 5HTt gene for...

journal_title：DNA and cell biology

authors： Akar T,Sayin A,Bakkaloğlu Z,Cabuk DK,Küçükyildirim S,Demirel B,Candansayar S,Ozsoy ED,Mergen H

更新日期：2010-08-01 00:00:00

abstract：:The recent explosion of scientific and technical knowledge in the field of molecular biology has allowed us to make important advances in our understanding of the molecular basis of many human diseases. This technology has now entered the clinical laboratory where identification of specific genetic sequences can aid i...

journal_title：DNA and cell biology

authors： Crisan D,Mattson JC

更新日期：1993-06-01 00:00:00

abstract：:A decrease in gap junctional, intercellular communication (GJIC) has been associated with cells neoplastically transformed by a variety of factors. To investigate the role of the Ras oncogene product in gap junction function, a panel of murine C3H10T1/2 (10T1/2) fibroblasts was constructed in which the levels of ras g...

journal_title：DNA and cell biology

authors： Brownell HL,Narsimhan RP,Corbley MJ,Mann VM,Whitfield JF,Raptis L

更新日期：1996-06-01 00:00:00

abstract：:The major surface promoter of human hepatitis B virus can produce three distinct groups of S transcripts. The initiation sites of these transcripts are in close proximity. Encompassing the ATG for the middle surface protein, the largest S transcript (+1) encodes the middle surface protein whereas the other two (+20 an...

journal_title：DNA and cell biology

authors： Kuo YL,Ting LP

更新日期：1997-05-01 00:00:00

abstract：:The liver has an excellent capacity for regeneration when faced with external injury and the damage differs from that of other organs in the body. Our aim was to identify the role of circular RNA (circRNA) during the DNA synthesis phase (36 h) of mice liver regeneration. High-throughput RNA sequencing was conducted to...

journal_title：DNA and cell biology

authors： Zhang J,Xu L,Wang P,Zheng X,Hu Y,Luo J,Zhang M,Xu M

更新日期：2020-11-01 00:00:00

abstract：:Aberrant neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. While the genotoxic function of PMNs and its implications in carcinogenesis have been primarily associated with oxidative stress, recent work by Butin-Israeli ...

journal_title：DNA and cell biology

authors： Bui TM,Sumagin R

更新日期：2019-08-01 00:00:00

abstract：:The promoter of the human urokinase plasminogen activator (uPA) gene contains a sequence identical with the retinoblastoma control element (RCE) of the murine c-fos gene, as well as several Sp1 binding sites. In a number of cell lines, the uPA promoter is activated during enforced expression of the retinoblastoma prot...

journal_title：DNA and cell biology

authors： Novak U,Paradiso L,Hamilton JA

更新日期：1994-11-01 00:00:00

abstract：:Parkinson's disease (PD) is a serious neurodegenerative disorder that lacks effective therapeutic methods. In this research, expressions of PPARα, RXRα, and miR-21 were evaluated in PD patients and normal controls. To investigate the effects of miR-21, docosahexaenoic acid (DHA) and aspirin (ASA) on PD, as well as the...

journal_title：DNA and cell biology

authors： Fu Y,Zhen J,Lu Z

更新日期：2017-06-01 00:00:00

abstract：:The breast cancer gene 1 (BRCA1) is a tumor suppressor, and mutations or epigenetic inactivation will increase the risk of breast cancer oncogenesis. The current research aimed to explore the relationship between BRCA1 expression, prognosis, and tumor immunity in hepatocellular carcinoma (HCC). In this study, BRCA1 ex...

journal_title：DNA and cell biology

authors： Mei J,Wang R,Xia D,Yang X,Zhou W,Wang H,Liu C

更新日期：2020-10-01 00:00:00

abstract：:Hepatic fibrosis is a reversible process involving plenty of transcription factors and pathways. Vitamin D receptor (VDR) as a member of ligand-induced transcription factors can interact with 9-cis retinoid X receptor (RXR) and VDR-interacting repressor (VDIR) to mediate transactivation or transrepression in the absen...

journal_title：DNA and cell biology

authors： Wan LY,Zhang YQ,Li JM,Tang HQ,Chen MD,Ni YR,Huang H,Liu CB,Wu JF

更新日期：2016-09-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) is known for its ability to infect immune cells, including T-cells and macrophages. The 96-amino acid Vpr, a virion-associated protein, is essential for viral replication in monocytes/macrophages and increases viral replication in primary and established T-cell lines. The Vp...

journal_title：DNA and cell biology

authors： Muthumani K,Montaner LJ,Ayyavoo V,Weiner DB

更新日期：2000-03-01 00:00:00

abstract：:The human immunodeficiency virus type I (HIV-1) accessory protein Vpr has been associated with the induction of programmed cell death (apoptosis) and cell-cycle arrest. Studies have shown the apoptotic effect of Vpr on primary and established cell lines and on diverse tissues including the central nervous system (CNS)...

journal_title：DNA and cell biology

authors： Cheng X,Mukhtar M,Acheampong EA,Srinivasan A,Rafi M,Pomerantz RJ,Parveen Z

更新日期：2007-02-01 00:00:00

abstract：:We evaluated the effects of administration of 1,25-dihydroxyvitamin D (1,25(OH)2D) during pregnancy on relieving adverse outcomes of preeclampsia and the pathologic and biochemical changes in reduction in uteroplacental perfusion (RUPP) model of rats. On day 1, 7, and 14 of pregnancy, rats in pregnant RUPP plus 1,25(O...

journal_title：DNA and cell biology

authors： Tian X,Ma S,Wang Y,Hou L,Shi Y,Yao M,Wang X,Zhang H,Jiang L

更新日期：2016-02-01 00:00:00

abstract：:Myocardial ischemic disease affects the prognosis in perioperative patients. Diabetes can aggravate myocardial injury. The purpose of this research is to investigate the effect of ferroptosis in the process of diabetes mellitus (DM) myocardial ischemia/reperfusion (I/R) injury (IRI). Endoplasmic reticulum stress (ERS)...

journal_title：DNA and cell biology

authors： Li W,Li W,Leng Y,Xiong Y,Xia Z

更新日期：2020-02-01 00:00:00

abstract：:Human immunodeficiency virus type I (HIV-1) infection leads to penetration of the central nervous system (CNS) in virtually all infected individuals and HIV-1-induced encephalopathy in a significant number of untreated patients. The molecular mechanisms by which HIV-1 enters the CNS and yields CNS dysfunction are stil...

journal_title：DNA and cell biology

authors： Pomerantz RJ

更新日期：2004-04-01 00:00:00

abstract：:My 45 years of studying the molecular biology of adeno-associated virus are recounted. Additional activities as a mentor, department chair, and medical school administrator are described, as are my activities in the public sphere, which involved national issues related to science policy and medical education. ...

journal_title：DNA and cell biology

authors： Berns KI

更新日期：2013-07-01 00:00:00

abstract：:Clusterin (CLU) and clathrin assembly lymphoid myeloid (CALM) protein are implicated in the function of neuronal synapses. However, to our knowledge, whether they play roles in the maldevelopment of synaptic pathways in schizophrenia has not been studied. The purpose of this study was to examine whether single nucleot...

journal_title：DNA and cell biology

authors： Zhou Y,Wang J,Wang K,Li S,Song X,Ye Y,Wang L,Ying B

更新日期：2010-12-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) production is regulated by growth factors and inflammatory cytokines, and VEGF plays a role in migraine. We examined for the first time whether three functional polymorphisms in the promoter region of VEGF gene (C(-2578)A, G(-1154)A, and G(-634)C) and VEGF haplotypes are assoc...

journal_title：DNA and cell biology

authors： Gonçalves FM,Martins-Oliveira A,Speciali JG,Izidoro-Toledo TC,Luizon MR,Dach F,Tanus-Santos JE

更新日期：2010-07-01 00:00:00

abstract：:We have further characterized the most distal of the three alpha-fetoprotein (AFP) enhancers required for expression of the AFP gene in fetal hepatocytes and yolk sac endodermal cells. Almost total rat AFP enhancer 3 (E3) activity is driven by a 160-bp fragment at -6 kb containing three target regions for nuclear prot...

journal_title：DNA and cell biology

authors： Thomassin H,Bois-Joyeux B,Delille R,Ikonomova R,Danan JL

更新日期：1996-12-01 00:00:00

abstract：:Sterol regulatory element-binding proteins (SREBPs) are transcription factors governing transcription of genes related to cholesterol and fatty acid metabolism. To become active, SREBPs must undergo a proteolytic cleavage to allow an active NH(2)-terminal segment to translocate into the nucleus. SKI-1/S1P is the first...

journal_title：DNA and cell biology

authors： De Windt A,Rai M,Bernier L,Thelen K,Soini J,Lefebvre C,Chintawar S,Lavigne J,Saarinen L,Kytömäki L,Munzer JS,Lütjohann D,Pandolfo M,Davignon J,Seidah NG,Laaksonen R

更新日期：2007-11-01 00:00:00

abstract：:Traditional histological classification of lung cancer subtypes is informative, but incomplete. Recent studies of gene expression suggest that molecular classification can be used for effective diagnostic and prediction of the treatment outcome. We attempt to build a molecular classification based on the public data a...

journal_title：DNA and cell biology

authors： Ptitsyn A

更新日期：2004-10-01 00:00:00

abstract：:Chromosomal gain on 1q23-24 is a cytogenetic finding found in approximately 30% of bladder tumors. Currently, no defined or candidate tumor-associated genes from this region have been identified. The objective of this study was to identify and quantitate the expression of putative cancer genes located at this chromoso...

journal_title：DNA and cell biology

authors： Huang WC,Taylor S,Nguyen TB,Tomaszewski JE,Libertino JA,Malkowicz SB,McGarvey TW

更新日期：2002-10-01 00:00:00

abstract：:We have cloned and mapped the chromosomal location of three novel human genes encoding G protein-coupled receptors that we have named GPR6, GPR5, and GPR4. The entire coding region for each of these genes was contained on single exons. Gene GPR6 encoded a receptor that shared closest identity (71% in the transmembrane...

journal_title：DNA and cell biology

authors： Heiber M,Docherty JM,Shah G,Nguyen T,Cheng R,Heng HH,Marchese A,Tsui LC,Shi X,George SR

更新日期：1995-01-01 00:00:00