Abstract：
INTRODUCTION:Childhood sexual abuse (CSA) has been associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in non-pregnant samples. However, it is not yet known whether CSA is associated with HPA dysregulation over pregnancy. In the present study we assessed whether maternal cortisol levels across pregnancy differed in women with CSA histories compared to women with histories of non-sexual child abuse (CA) and no abuse (NA). METHODS:135 pregnant mothers (CSA=30, CA=58, NA=47) provided salivary cortisol samples at wakeup, wake +30 min, and bedtime for 3 consecutive days at 1-3 time points over second and third trimester. Cortisol awakening responses and slopes were computed. RESULTS:Women with CSA histories displayed increasing cortisol awakening response over pregnancy compared to women with CA and NA histories. Group differences were not observed for slope. CONCLUSIONS:This is the first study to show that cortisol awakening responses increase over pregnancy in women with CSA histories compared to women with CA and NA histories.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Bublitz MH,Stroud LRdoi
10.1016/j.psyneuen.2012.01.009subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1425-30issue
9eissn
0306-4530issn
1873-3360pii
S0306-4530(12)00031-5journal_volume
37pub_type
杂志文章abstract：:We injected ovariectomized female rats with estrogen and progesterone. Some of the injection regimens used are known to induce estrus, while other do not. The effects of these treatments on operant behavior were evaluated. Operant behavior was maintained under a reinforcement schedule, one segment of which involved ex...
journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/S0306-4530(03)00103-3
更新日期：2004-07-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2008.09.006
更新日期：2009-02-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2014.05.020
更新日期：2014-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,随机对照试验
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更新日期：2010-10-01 00:00:00
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.10.012
更新日期：2014-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2018.09.028
更新日期：2019-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2009.05.012
更新日期：2009-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.11.009
更新日期：2016-02-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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更新日期：2012-08-01 00:00:00
