Abstract:
:Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p=0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Osborne LM,Gispen F,Sanyal A,Yenokyan G,Meilman S,Payne JLdoi
10.1016/j.psyneuen.2017.02.012subject
Has Abstractpub_date
2017-05-01 00:00:00pages
116-121eissn
0306-4530issn
1873-3360pii
S0306-4530(16)30881-2journal_volume
79pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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