Abstract：
OBJECTIVE:To investigate the neuroendocrinological stress response to acute psychosocial stress in a clinical sample of female adolescents engaging in nonsuicidal self-injury (NSSI). METHODS:The Trier Social Stress Test (TSST), a standardized psychosocial stress protocol, was performed in 14 female patients who engaged in NSSI and 14 healthy control subjects. NSSI was assessed by the Functional Assessment of Self-Mutilation (FASM). Salivary cortisol, heart rate, and affective states, assessed by the Positive and Negative Affect Schedule (PANAS), were measured during the TSST. RESULTS:We found an attenuated cortisol response to acute psychosocial stress in female adolescents with NSSI, whereas no group differences were observed in heart rate and emotional response to the TSST. CONCLUSIONS:These findings indicate that the HPA axis is hyporesponsive in adolescents with NSSI. Therefore, reduced secretion of cortisol could play a role in promoting vulnerability of these individuals to acute stress and maladaptive stress responses.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Kaess M,Hille M,Parzer P,Maser-Gluth C,Resch F,Brunner Rdoi
10.1016/j.psyneuen.2011.05.009subject
Has Abstractpub_date
2012-01-01 00:00:00pages
157-61issue
1eissn
0306-4530issn
1873-3360pii
S0306-4530(11)00162-4journal_volume
37pub_type
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