Abstract:
:Since its discovery more than a century ago, oxytocin has become one of the most intensively studied molecules in behavioral biology. In the last five years, Psychoneuroendocrinology has published more than 500 articles with oxytocin in the title, with many of these articles including measures of endogenous oxytocin concentrations. Despite longstanding interest, methods of measuring endogenous oxytocin are still in active development. The widely varying oxytocin concentrations detected by different approaches to measurement - and lack of correlation among these techniques - has led to controversy and confusion. We identify features of oxytocin that may help to explain why various approaches may be differentially sensitive to diverse conformational states of the oxytocin molecule. We propose that discrepancies in data generated by different methods of measurement are not necessarily an indicator that some methods are valid whereas others are not. Rather, we propose that current challenges in the measurement of oxytocin may be analogous to the parable of the blind men and the elephant, with different methods of sample preparation and measurement being sensitive to different states in which the oxytocin molecule can exist.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
MacLean EL,Wilson SR,Martin WL,Davis JM,Nazarloo HP,Carter CSdoi
10.1016/j.psyneuen.2019.05.018subject
Has Abstractpub_date
2019-09-01 00:00:00pages
225-231eissn
0306-4530issn
1873-3360pii
S0306-4530(19)30238-0journal_volume
107pub_type
杂志文章,评审abstract:INTRODUCTION:Individuals who are exposed to a traumatic event are at increased risk of developing psychiatric disorders such as posttraumatic stress disorder (PTSD). Studies have shown that increased amygdala activity is frequently found in patients with PTSD. In addition, pre-trauma glucocorticoid receptor (GR) number...
journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Psychoneuroendocrinology
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pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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更新日期:2012-08-01 00:00:00
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更新日期:1986-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2019.104544
更新日期:2020-03-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-02-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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更新日期:1988-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2017.11.004
更新日期:2018-02-01 00:00:00