当前位置： SCI文献检索 > PSYCHONEUROENDOCRINOLOGY期刊下所有文献 > Impaired hormonal regulation of appetite in schizophrenia: A narrative review dissecting intrinsic mechanisms and the effects of antipsychotics.

Impaired hormonal regulation of appetite in schizophrenia: A narrative review dissecting intrinsic mechanisms and the effects of antipsychotics.

Abstract：

:Cardiometabolic diseases are the main contributor of reduced life expectancy in patients with schizophrenia. It is now widely accepted that antipsychotic treatment plays an important role in the development of obesity and its consequences. However, some intrinsic mechanisms need to be taken into consideration. One of these mechanisms might be related to impaired hormonal regulation of appetite in this group of patients. In this narrative review, we aimed to dissect impairments of appetite-regulating hormones attributable to intrinsic mechanisms and those related to medication effects. Early hormonal alterations that might be associated with intrinsic mechanisms include low levels of leptin and glucagon-like peptide-1 (GLP-1) together with elevated insulin levels in first-episode psychosis (FEP) patients. However, evidence regarding low GLP-1 levels in FEP patients is based on one large study. In turn, multiple-episode schizophrenia patients show elevated levels of insulin, leptin and orexin A together with decreased levels of adiponectin. In addition, patients receiving olanzapine may present with low ghrelin levels. Post mortem studies have also demonstrated reduced number of neuropeptide Y neurons in the prefrontal cortex of patients with schizophrenia. Treatment with certain second-generation antipsychotics may also point to these alterations. Although our understanding of hormonal regulation of appetite in schizophrenia has largely been improved, several limitations and directions for future studies need to be addressed. This is of particular importance since several novel pharmacological interventions for obesity and diabetes have already been developed and translation of these developments to the treatment of cardiometabolic comorbidities in schizophrenia patients is needed.

journal_name

Psychoneuroendocrinology

journal_title

Psychoneuroendocrinology

authors

Lis M,Stańczykiewicz B,Liśkiewicz P,Misiak B

doi

10.1016/j.psyneuen.2020.104744

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

104744

eissn

0306-4530

issn

1873-3360

pii

S0306-4530(20)30163-3

journal_volume

119

pub_type

杂志文章,评审

相关文献

PSYCHONEUROENDOCRINOLOGY文献大全
  • The serum glucose response to acute stress is sensitive to the intensity of the stressor and to habituation.

    abstract：:The reliability of serum glucose concentrations as an index of habituation to chronic stress was evaluated in adult male rats. The glucose response to immobilization was attenuated by six days of previous chronic exposure to the same stressor, the degree of reduction being related to the duration (15 min, 1 hr or 4 hr...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/0306-4530(90)90059-i

    authors： Armario A,Marti J,Gil M

    更新日期：1990-01-01 00:00:00

  • The social curse: Evidence for a moderating effect of shared social identity on contagious stress reactions.

    abstract：:Contagious stress describes the transmission of a stress response from a distressed individual (target) to an uninvolved observer. Building on social identity theory, we hypothesize that a shared social identity between the observer and the target as compared to a personal identity increases the likelihood of contagio...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.104896

    authors： Schury VA,Nater UM,Häusser JA

    更新日期：2020-12-01 00:00:00

  • Prolactin response to low-dose haloperidol challenge in schizophrenic, non-schizophrenic psychotic, and control subjects.

    abstract：:Haloperidol was administered IV to 46 male psychotic inpatients and 28 male control subjects. A two-way analysis of covariance, with age as the covariate, revealed that DSM-III schizophrenics (n = 27) had a lower prolactin response to haloperidol than did the controls (n = 28). There were no significant differences be...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/0306-4530(90)90033-6

    authors： Copolov DL,Keks NA,Kulkarni J,Singh BS,McKenzie D,McGorry P,Hill C

    更新日期：1990-01-01 00:00:00

  • Endotoxin elicits ambivalent social behaviors.

    abstract：:The acute phase response to infection is reliably accompanied by decreases in social investigation; however, social behavior is commonly assayed in inescapable environments using unfamiliar social stimuli. In this experiment, male Wistar rats were raised from weaning with 2 familiar, same-sex conspecifics. In adulthoo...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2011.11.008

    authors： Yee JR,Prendergast BJ

    更新日期：2012-07-01 00:00:00

  • Molecular markers of neuroendocrine function and mitochondrial biogenesis associated with early life stress.

    abstract：OBJECTIVE:Glucocorticoid receptor gene (NR3C1) promoter methylation influences cellular expression of the glucocorticoid receptor and is a proposed mechanism by which early life stress impacts neuroendocrine function. Mitochondria are sensitive and responsive to neuroendocrine stress signaling through the glucocorticoi...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.104632

    authors： Ridout KK,Coe JL,Parade SH,Marsit CJ,Kao HT,Porton B,Carpenter LL,Price LH,Tyrka AR

    更新日期：2020-06-01 00:00:00

  • Serotonin regulation of the human stress response.

    abstract：:Acute tryptophan depletion (ATD) is a technique that has been used to evaluate the effects on humans of acutely reducing serotonin neurotransmission. We have developed a model using a single breath of 35% CO(2) that activates the hormonal axis and produces autonomic and behavioural arousal, thus modelling a stress res...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.psyneuen.2006.07.001

    authors： Hood SD,Hince DA,Robinson H,Cirillo M,Christmas D,Kaye JM

    更新日期：2006-10-01 00:00:00

  • Effects of change of mothers and lighting conditions on the development of the circadian adrenocortical rhythm in blinded rat pups.

    abstract：:Free-running blood corticosterone rhythms were examined between the 4th and 9th postnatal week in blinded rat pups optically enucleated on day 1. The pups were born of mother rats having a free-running rhythm under constant illumination conditions and then were put under two separate illumination conditions (light - d...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/0306-4530(83)90060-4

    authors： Yamazaki J,Takahashi K

    更新日期：1983-01-01 00:00:00

  • Cultures under stress: A cross-national meta-analysis of cortisol responses to the Trier Social Stress Test and their association with anxiety-related value orientations and internalizing mental disorders.

    abstract：:Acute cortisol changes are physiological indicators (i.e., biomarkers) of psychosocial stress that have been repeatedly assessed using standardized laboratory protocols like the Trier Social Stress Test (TSST). Despite this methodological standardization, however, cortisol stress responses vary considerably across dif...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.psyneuen.2018.12.236

    authors： Miller R,Kirschbaum C

    更新日期：2019-07-01 00:00:00

  • Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model.

    abstract：BACKGROUND:Stress evokes lipolytic release of free fatty acid (FFA) and low-grade inflammation in visceral adipose tissue, mediated by increased adipokine secretion, and contributes to glucose metabolism disorder and prothrombotic state. We tested the hypothesis that alogliptin, a dipeptidyl peptidase-4 inhibitor, can ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2016.08.004

    authors： Yisireyili M,Takeshita K,Hayashi M,Wu H,Uchida Y,Yamamoto K,Kikuchi R,Hao CN,Nakayama T,Cheng XW,Matsushita T,Nakamura S,Murohara T

    更新日期：2016-11-01 00:00:00

  • Frontal lobe proton magnetic-resonance spectroscopy in Graves' disease: a pilot study.

    abstract：:Patients with hyperthyroidism may show impaired performance on several neuropsychological tests that require complex visual discrimination, conceptualization, mental flexibility or organization. These neurocognitive impairments appear to be consistent with prefrontal lobe dysfunction. This pilot study was undertaken t...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0306-4530(98)00028-6

    authors： Bhatara VS,Tripathi RP,Sankar R,Gupta A,Khushu S

    更新日期：1998-08-01 00:00:00

  • Neural basis of maternal behavior in the rat.

    abstract：:This article presents a review of the neural and neurochemical regulation of maternal behavior in the rat, emphasizing the role of the medial preoptic area (MPOA) and its neural connections in this regulation. Evidence for the role of the MPOA includes the following and will be discussed: (1) Axon-sparing lesions of t...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/0306-4530(88)90006-6

    authors： Numan M

    更新日期：1988-01-01 00:00:00

  • Use of a resting control day in measuring the cortisol response to mental stress: diurnal patterns, time of day, and gender effects.

    abstract：:In laboratory studies of individual differences in stress reactivity, cortisol responses are typically measured by comparing a prestress baseline with values obtained at the end of the stressor. In the present study, we measured cortisol in this manner on a stress day, but we also took samples on a second day when the...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2010.02.015

    authors： Lovallo WR,Farag NH,Vincent AS

    更新日期：2010-09-01 00:00:00

  • The impact of social interaction factors on menstrual synchrony in the workplace.

    abstract：:The two objectives of this study were: (1) to examine the impact of social interaction variables (e.g., friendship, time working together, and activity) on the occurrence of menstrual synchrony; (2) to examine the menstrual synchrony of women who work together in an office. The sample consisted of 72 women soldiers in...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/0306-4530(94)e0004-s

    authors： Weller A,Weller L

    更新日期：1995-01-01 00:00:00

  • Childhood adversity and cortisol habituation to repeated stress in adulthood.

    abstract：BACKGROUND:Childhood adversity is a robust predictor of poor health outcomes in adulthood and hypothalamic-pituitary-adrenocortical (HPA) axis dysfunction may be a key mechanism explaining this association. However, little is known about the influence childhood adversity may exhibit on adult HPA axis habituation (i.e.,...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.105118

    authors： Appelmann HM,Manigault AW,Shorey RC,Zoccola PM

    更新日期：2020-12-24 00:00:00

  • The role of the amygdala in human fear: automatic detection of threat.

    abstract：:Behavioral data suggest that fear stimuli automatically activate fear and capture attention. This effect is likely to be mediated by a subcortical brain network centered on the amygdala. Consistent with this view, brain imaging studies show that masked facial stimuli activate the amygdala as do masked pictures of thre...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.psyneuen.2005.03.019

    authors： Ohman A

    更新日期：2005-11-01 00:00:00

  • Differences in the response to the combined DEX-CRH test between PTSD patients with and without co-morbid depressive disorder.

    abstract：BACKGROUND:Neuroendocrine studies have shown profound alterations in HPA-axis regulation in posttraumatic stress disorder (PTSD). Based on baseline assessments and the response to dexamethasone, a hypothalamic overdrive with enhanced glucocorticoid feedback inhibition has been suggested. The dexamethasone-corticotrophi...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2007.11.016

    authors： de Kloet C,Vermetten E,Lentjes E,Geuze E,van Pelt J,Manuel R,Heijnen C,Westenberg H

    更新日期：2008-04-01 00:00:00

  • Cortisol awakening response in infants during the first six postnatal months and its relation to birth outcome.

    abstract：CONTEXT:The rise of cortisol concentrations after awakening is well documented in adults and children and commonly used as easily accessible marker of hypothalamic-pituitary-adrenal (HPA) reactivity. OBJECTIVE:The purpose of this study was to demonstrate the existence of a salivary cortisol awakening response (CAR) in...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2012.08.002

    authors： Tegethoff M,Knierzinger N,Meyer AH,Meinlschmidt G

    更新日期：2013-05-01 00:00:00

  • Night sleep EEG and daytime sleep propensity in adult hypopituitary patients with growth hormone deficiency before and after six months of growth hormone replacement.

    abstract：BACKGROUND:Hypopituitary patients with growth hormone deficiency (GHD) complain of reduced vitality, general fatigue, lack of concentration, irritability and reduced alertness during daytime. It is unclear whether these symptoms are primarily due to GH-deficiency and/or secondary to GHD related sleep impairments. Bi-di...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.psyneuen.2004.05.004

    authors： Schneider HJ,Oertel H,Murck H,Pollmächer T,Stalla GK,Steiger A

    更新日期：2005-01-01 00:00:00

  • Associations of plasma testosterone with clinical manifestations in acute panic disorder.

    abstract：:The probable implication of testosterone in the neurobiology of anxiety disorders, and particularly panic disorder (PD), is poorly studied. We explored for potential differences concerning testosterone (T) plasma levels and the ratio testosterone/cortisol (T/C) between medication-free, consecutively-referred patients ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2018.11.017

    authors： Masdrakis VG,Papageorgiou C,Markianos M

    更新日期：2019-03-01 00:00:00

  • Role of nesfatin-1 in anxiety, depression and the response to stress.

    abstract：:Nesfatin-1 has been discovered a decade ago and since then drawn a lot of attention. The initially proposed anorexigenic effect was followed by the description of several other involvements such as a role in gastrointestinal motility, glucose homeostasis, cardiovascular functions and thermoregulation giving rise to a ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.psyneuen.2018.09.037

    authors： Weibert E,Hofmann T,Stengel A

    更新日期：2019-02-01 00:00:00

  • HPA system regulation and adult attachment anxiety: individual differences in reactive and awakening cortisol.

    abstract：:Early life experiences can influence hypothalamus-pituitary-adrenal (HPA) axis regulation in adulthood, in both animals and humans. In humans, they have also been shown to influence adult attachment styles. However, the relationship between adult attachment styles and HPA axis regulation is largely unexplored. The pre...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2008.01.013

    authors： Quirin M,Pruessner JC,Kuhl J

    更新日期：2008-06-01 00:00:00

  • Psychosocial factors, respiratory viruses and exacerbation of asthma.

    abstract：:The aim of this research was study the role of psychosocial factors in exacerbations of asthma in adults induced by upper respiratory tract infections (URTIs). It involved a longitudinal study (one year) of 92 adults with asthma. The volunteers were 27 men and 65 women 19-46 years of age with a mean duration of wheeze...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/s0306-4530(00)00063-9

    authors： Smith A,Nicholson K

    更新日期：2001-05-01 00:00:00

  • Effects of blood glucose on delay discounting, food intake and counterregulation in lean and obese men.

    abstract：BACKGROUND:Delay discounting as a measure of impulsivity has been shown to be higher in obesity with an association of increased food intake. Moreover, obese humans showed a higher wanting for high-calorie food than lean men when blood glucose concentrations were low. First studies linking blood glucose levels to delay...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2018.01.014

    authors： Klement J,Kubera B,Eggeling J,Rädel C,Wagner C,Park SQ,Peters A

    更新日期：2018-03-01 00:00:00

  • Ethinyl estradiol and levonorgestrel alter cognition and anxiety in rats concurrent with a decrease in tyrosine hydroxylase expression in the locus coeruleus and brain-derived neurotrophic factor expression in the hippocampus.

    abstract：:In the United States, more than ten million women use contraceptive hormones. Ethinyl estradiol and levonorgestrel have been mainstay contraceptive hormones for the last four decades. Surprisingly, there is scant information regarding their action on the central nervous system and behavior. Intact female rats received...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2015.08.015

    authors： Simone J,Bogue EA,Bhatti DL,Day LE,Farr NA,Grossman AM,Holmes PV

    更新日期：2015-12-01 00:00:00

  • Sex differences in the cannabinoid regulation of energy homeostasis.

    abstract：:This review highlights the progress made thus far in characterizing the behavioral and cellular mechanisms through which cannabinoids regulate energy homeostasis. We performed microstructural analysis of feeding behavior in gonadectomized guinea pigs and gonadally intact, transgenic CB1 receptor knockout mice to deter...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.psyneuen.2009.04.007

    authors： Farhang B,Diaz S,Tang SL,Wagner EJ

    更新日期：2009-12-01 00:00:00

  • Cortisol fluctuates with increases and decreases in negative affect.

    abstract：:Prior studies have reported cortisol secretion to be primarily influenced by negative affect, but less is known about cortisol activity during states of activation involving increased positive affect and decreased negative affect. On separate days, 30 healthy young men experienced: an activating and humorous video; a ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/s0306-4530(98)00078-x

    authors： Buchanan TW,al'Absi M,Lovallo WR

    更新日期：1999-02-01 00:00:00

  • Preliminary evidence for obesity and elevations in fasting insulin mediating associations between cortisol awakening response and hippocampal volumes and frontal atrophy.

    abstract：:Recent studies have demonstrated alterations in the cortisol awakening response (CAR) and brain abnormalities in adults with obesity and type 2 diabetes mellitus (T2DM). While adolescents with T2DM exhibit similar brain abnormalities, less is known about whether brain impairments and hypothalamic-pituitary-adrenal (HP...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2011.12.020

    authors： Ursache A,Wedin W,Tirsi A,Convit A

    更新日期：2012-08-01 00:00:00

  • Vasopressin deficiency diminishes acute and long-term consequences of maternal deprivation in male rat pups.

    abstract：:Early life events have special importance in the development as postnatal environmental alterations may permanently affect the lifetime vulnerability to diseases. For the interpretation of the long-term consequences it is important to understand the immediate effects. As the role of vasopressin in hypothalamic-pituita...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2014.10.018

    authors： Zelena D,Stocker B,Barna I,Tóth ZE,Makara GB

    更新日期：2015-01-01 00:00:00

  • A role for glucocorticoids in the long-term establishment of a social hierarchy.

    abstract：:Stress can affect the establishment and maintenance of social hierarchies. In the present study, we investigated the role of increasing corticosterone levels before or just after a first social encounter between two rats of a dyad in the establishment and the long-term maintenance of a social hierarchy. We show that p...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2010.05.011

    authors： Timmer M,Sandi C

    更新日期：2010-11-01 00:00:00

  • Effects of psycho-social stress during pregnancy on neuroendocrine and behavioural parameters in lactation depend on the genetically determined stress vulnerability.

    abstract：:The neuroendocrine consequences of repeated exposure of the pregnant mother to relevant stressors have been studied in the offspring, but not in the mothers. As these stress effects might depend on the genetically determined stress susceptibility of the dams, here, we investigated the effects of daily exposure to psyc...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2005.03.008

    authors： Neumann ID,Krömer SA,Bosch OJ

    更新日期：2005-09-01 00:00:00