Abstract:
:This study investigated the diurnal output of saliva cortisol in women with symptoms of depression postnatally. Twenty-one depressed and 30 non-depressed women at 7.5 weeks postpartum, and 21 non-perinatal controls, collected saliva at waking, 30 min, and 3 and 12h postwaking. Women who were not depressed postnatally showed a pattern of cortisol secretion over the day similar to non-perinatal controls. There was a significant difference in diurnal pattern between postnatally depressed and postnatally non-depressed women, due to a difference in the first two time points (waking and +30 min): compared to the other two groups who each had a significant increase in cortisol levels from waking to +30 min, the depressed women had significantly higher cortisol levels at waking and no increase at +30 min. The lack of a morning rise in the depressed women is similar to that reported for posttraumatic stress disorder and chronic fatigue syndrome and may reflect a response, in vulnerable women, to the marked cortisol withdrawal that occurs after delivery.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Taylor A,Glover V,Marks M,Kammerer Mdoi
10.1016/j.psyneuen.2009.03.004subject
Has Abstractpub_date
2009-09-01 00:00:00pages
1184-8issue
8eissn
0306-4530issn
1873-3360pii
S0306-4530(09)00087-0journal_volume
34pub_type
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