Abstract：
:The effects on retrieval of a one-trial learning inhibitory avoidance response of beta-endorphin, alpha-endorphin, and gamma-endorphin, given prior to test have been studied in rats. beta-Endorphin (beta-LPH 61-91) in a relatively low dose (1.56 micrograms sc. or 50 ng icv.) facilitated inhibitory avoidance behavior, while a higher dose (10 micrograms sc. or 100 ng icv.) caused bimodal changes (facilitation in 50% of the animals and attenuation in another 40%. Peripheral injection of gamma-endorphin attenuated inhibitory avoidance behaviour in a dose-dependent manner. The C-terminus of beta-endorphin (beta-LPH 78-91) was ineffective. alpha-Endorphin facilitated inhibitory avoidance behavior in a dose dependent manner. Naltrexone pretreatment antagonized the bimodal effect of beta-endorphin: following pretreatment with the opiate antagonist the low latency component disappeared, but the facilitatory effect of the neuropeptide remained the same. It is suggested that beta-endorphin carries more than one bit of behavioral information. Inherent activities either related or unrelated to naltrexone-sensitive opiate as well as biotransformation into alpha- and gamma-endorphin may contribute to the multiple behavioral effects of this neuropeptide.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Kovàcs GL,Bohus B,De Wied Ddoi
10.1016/0306-4530(83)90020-3subject
Has Abstractpub_date
1983-01-01 00:00:00pages
411-9issue
4eissn
0306-4530issn
1873-3360journal_volume
8pub_type
杂志文章abstract：:Antidepressants such as SSRIs or mirtazapine have been demonstrated to increase the concentrations of 3alpha-reduced neuroactive steroids throughout several weeks of treatment. However, no data are available on the impact of mood stabilizers such as lithium or carbamazepine on neuroactive steroid levels in depressed p...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.04.004
更新日期：2007-07-01 00:00:00
abstract：:The purpose of this study was to test the relationship between social environment and the activity of the HPA axis in adolescents. Ten elective admissions to Children's Hospital at Stanford were assessed by standard psychiatric interview. Five fulfilled criteria for a DSM-III diagnosis, five others did not. The groups...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(88)90058-3
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.02.001
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
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journal_title：Psychoneuroendocrinology
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更新日期：2015-10-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2018.12.233
更新日期：2019-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2017.10.005
更新日期：2018-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.10.017
更新日期：2017-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2020.104744
更新日期：2020-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.07.006
更新日期：2007-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
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更新日期：2011-02-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2014.10.021
更新日期：2015-02-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2008.08.008
更新日期：2009-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.03.029
更新日期：2019-08-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2017.11.010
更新日期：2018-02-01 00:00:00
abstract：:Stress and inflammation are both important risk factors for coronary artery disease (CAD). However, the susceptibility to stress-induced inflammation and its determinants have been little explored in patients with CAD. Here, our aim was to study the stress-induced inflammatory response, more precisely the early releas...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.07.219
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,meta分析,评审
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
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更新日期：2006-10-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：1999-02-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.07.019
更新日期：2013-12-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(01)00087-7
更新日期：2002-10-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2008.11.010
更新日期：2009-06-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2018.06.020
更新日期：2018-10-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2003-08-01 00:00:00
