Microglial-driven changes in synaptic plasticity: A possible role in major depressive disorder.

abstract：:Central dopaminergic dysfunction has been suggested to be involved in the pathogenesis of obsessive compulsive disorder (OCD). In 15 patients with OCD and in 15 age-sex matched controls we evaluated the dopamine (DA) function by measuring the cortisol (CORT) responses to stimulation with the DA agonist apomorphine (AP...

journal_title：Psychoneuroendocrinology

authors： Brambilla F,Perna G,Bussi R,Bellodi L

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with de...

journal_title：Psychoneuroendocrinology

authors： Krogh J,Ströhle A,Westrin A,Klausen T,Jørgensen MB,Nordentoft M

更新日期：2011-06-01 00:00:00

abstract：:Grief is conceptualized by strong negative emotions, which include longing, sadness, and preoccupations with thoughts, recollections, and images of the spouse. In the initial months after the loss of a spouse, those who are widowed are at risk for cardiovascular problems and premature mortality. In the general populat...

journal_title：Psychoneuroendocrinology

authors： Fagundes CP,Brown RL,Chen MA,Murdock KW,Saucedo L,LeRoy A,Wu EL,Garcini LM,Shahane AD,Baameur F,Heijnen C

更新日期：2019-02-01 00:00:00

abstract：:Anabolic-androgenic steroid (AAS) abuse is widespread. Moreover, AAS are reinforcing, as shown by self-administration in rodents. However, the receptors that transduce the reinforcing effects of AAS are unclear. AAS may bind to classical nuclear androgen receptors (ARs) or membrane receptors. We used two approaches to...

journal_title：Psychoneuroendocrinology

authors： Sato SM,Johansen JA,Jordan CL,Wood RI

更新日期：2010-08-01 00:00:00

abstract：:Diabetes is a highly prevalent, chronic disease that requires ongoing, multi-specialty medical care combined with patient self-management, family support, and education to prevent or delay end-organ morbidity and mortality. There is clearly an increased prevalence of major depressive disorder, a relatively common and ...

journal_title：Psychoneuroendocrinology

authors： Rustad JK,Musselman DL,Nemeroff CB

更新日期：2011-10-01 00:00:00

abstract：:The normal diurnal cortisol cycle has a peak in the morning, decreasing rapidly over the day, with low levels during the night, then rising rapidly again to the morning peak. A pattern of flatter daytime slopes has been associated with more rapid cancer progression in both animals and humans. We studied the relationsh...

journal_title：Psychoneuroendocrinology

authors： Spiegel D,Giese-Davis J,Taylor CB,Kraemer H

更新日期：2006-11-01 00:00:00

abstract：:Research has suggested that stressful situations lead to a decrease in testosterone, whereas concern with one's social status increases testosterone. However, results from studies examining testosterone reactivity in stressful situations that involve evaluation by others (hence status concerns) are inconsistent. Furth...

journal_title：Psychoneuroendocrinology

authors： Bedgood D,Boggiano MM,Turan B

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Late life depression and perceived stress could influence disease pathways via reduced 11β-HSD2 activity, particularly given suggestions that reduced 11β-HSD2 activity, which is reflected in the cortisol-to-cortisone ratio, is a risk factor of disease. To date, however, examination of the relationship betwee...

journal_title：Psychoneuroendocrinology

authors： Shimanoe C,Matsumoto A,Hara M,Akao C,Nishida Y,Horita M,Nanri H,Higaki Y,Tanaka K

更新日期：2020-12-30 00:00:00

abstract：:The neonatal nutritional environment is critical for programming the systems regulating body weight, and an inappropriate nutritional environment in early life can lead to overweight or obesity later on. In this study we demonstrate that changes to the neonatal nutritional environment, induced by changing the litter s...

journal_title：Psychoneuroendocrinology

authors： Spencer SJ,Tilbrook A

更新日期：2009-09-01 00:00:00

abstract：:We have studied the effects of ketanserin, a specific 5-HT2 antagonist, and zimelidine, a selective inhibitor of 5-HT re-uptake into central nervous system presynaptic terminals, upon basal and TRH stimulated serum TSH and prolactin levels in euthyroid individuals. Ten normal volunteers were studied (five male and fiv...

journal_title：Psychoneuroendocrinology

authors： O'Malley BP,Jennings PE,Cook N,Barnett DB,Rosenthal FD

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:This report evaluated sex-specific differences in the association between brain aging and body mass index (BMI) in young adults using the publicly available data from the Human Connectome Project (HCP). METHODS:Participants of HCP with available structural imaging and BMI data were included [n = 1112; mean ...

journal_title：Psychoneuroendocrinology

authors： Chin Fatt CR,Jha MK,Minhajuddin A,Mayes T,Trivedi MH

更新日期：2020-11-16 00:00:00

abstract：:Prenatal exposure to testosterone has been shown to affect fetal brain maturation as well as postnatal cognition and behavior in animal studies. Although there are well-established sex-differences in the use of social communication (or 'pragmatic language') in humans, there has been limited investigation of the associ...

journal_title：Psychoneuroendocrinology

authors： Whitehouse AJ,Maybery MT,Hart R,Mattes E,Newnham JP,Sloboda DM,Stanley FJ,Hickey M

更新日期：2010-09-01 00:00:00

abstract：:The probable implication of testosterone in the neurobiology of anxiety disorders, and particularly panic disorder (PD), is poorly studied. We explored for potential differences concerning testosterone (T) plasma levels and the ratio testosterone/cortisol (T/C) between medication-free, consecutively-referred patients ...

journal_title：Psychoneuroendocrinology

authors： Masdrakis VG,Papageorgiou C,Markianos M

更新日期：2019-03-01 00:00:00

abstract：:We evaluated a 37-year-old male with a non-24-h sleep-wake disorder. His environment gave him little exposure to bright light. Circadian profiles of temperature, melatonin, thyrotropin, cortisol and testosterone were obtained along with endocrine challenges of the thyroid, adrenal, growth hormone and gonadal axes. Mul...

journal_title：Psychoneuroendocrinology

authors： Oren DA,Giesen HA,Wehr TA

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Sex differences in levels of C-reactive protein (CRP) are well established in adulthood, but little is known about when and why they emerge. Here, we tested longitudinal models of CRP levels from ages 9 to 21, when marked physical and behavioral changes could contribute to growing sex disparities in CRP. ME...

journal_title：Psychoneuroendocrinology

authors： Shanahan L,Copeland WE,Worthman CM,Erkanli A,Angold A,Costello EJ

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Subtle and inconsistent differences in hypothalamic-pituitary-adrenal (HPA) axis activity have been reported for patients with panic disorder. While these patients show little or no alterations in basal ACTH and cortisol levels, it has been hypothesized that HPA hyperresponsivity was a trait in panic patient...

journal_title：Psychoneuroendocrinology

authors： Petrowski K,Herold U,Joraschky P,Wittchen HU,Kirschbaum C

更新日期：2010-04-01 00:00:00

abstract：:Whereas much is known about the function of the hypothalamic-pituitary-adrenal (HPA) axis during environmental stress and in psychiatric disorders, little is known about the relation of individual differences in basal HPA-functioning to individual differences in healthy psychological functioning. In the present study,...

journal_title：Psychoneuroendocrinology

authors： Zorrilla EP,DeRubeis RJ,Redei E

更新日期：1995-01-01 00:00:00

abstract：:Interpersonal touch is frequently used for communicating emotions, strengthen social bonds and to give others pleasure. The neuropeptide oxytocin increases social interest, improves recognition of others' emotions, and it is released during touch. Here, we investigated how oxytocin and gentle human touch affect social...

journal_title：Psychoneuroendocrinology

authors： Ellingsen DM,Wessberg J,Chelnokova O,Olausson H,Laeng B,Leknes S

更新日期：2014-01-01 00:00:00

abstract：:Cortisol, the primary glucocorticoid (GC) in humans, influences neuronal excitability and plasticity by acting on mineralocorticoid and glucocorticoid receptors. Cellular studies demonstrated that elevated GC levels affect neuronal plasticity, for example through a reduction of hippocampal long-term potentiation (LTP)...

journal_title：Psychoneuroendocrinology

authors： Dinse HR,Kattenstroth JC,Lenz M,Tegenthoff M,Wolf OT

更新日期：2017-03-01 00:00:00

abstract：:We have repeated a study of the objective (labium minus temperature) and subjective (semantic scales) changes in sexual arousability over the menstrual cycle to erotic video stimulation in 20 women with natural cycles. We extended the study with concomitant vibrotactile stimulation of the clitoral region. In an earlie...

journal_title：Psychoneuroendocrinology

authors： Slob AK,Bax CM,Hop WC,Rowland DL,van der Werff ten Bosch JJ

更新日期：1996-08-01 00:00:00

abstract：:The prolactin (PRL) and cortisol responses to oral D-fenfluramine (30 mg) and placebo were measured in seven healthy subjects (two women and five men) in the morning and in the afternoon. As compared to placebo, D-fenfluramine significantly increased plasma PRL levels in both the morning and the afternoon, with no sig...

journal_title：Psychoneuroendocrinology

authors： Monteleone P,Bortolotti F,Orazzo C,Serino I,Maj M

更新日期：1997-02-01 00:00:00

abstract：:Stress is a multidimensional construct. To accurately represent stress physiology, multiple stress measures across multiple stress-related systems should be assessed. However, associations may be masked given that different systems underlie different time courses. Salivary cortisol and alpha-amylase (sAA) are reliable...

journal_title：Psychoneuroendocrinology

authors： Engert V,Vogel S,Efanov SI,Duchesne A,Corbo V,Ali N,Pruessner JC

更新日期：2011-10-01 00:00:00

abstract：:Recent cross-species research has demonstrated that the neurohormone oxytocin plays a key role in social interaction and cognitive processing of others' emotions. Whereas oxytocin has been shown to influence social approach, trust, and bond formation, a potential role of the oxytocinergic system in blurring or enhanci...

journal_title：Psychoneuroendocrinology

authors： Colonnello V,Chen FS,Panksepp J,Heinrichs M

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Seasonal changes in mood and behaviour are commonly reported in the general population but considerably less is known regarding seasonality and pregnancy. This study investigated the relationship between seasons and depression and anxiety symptoms, salivary cortisol concentrations, custom birthweight centile...

journal_title：Psychoneuroendocrinology

authors： Garay SM,Savory KA,Sumption LA,Penketh RJA,Jones IR,Janssen AB,John RM

更新日期：2019-10-01 00:00:00

abstract：:Childhood maltreatment leads to a host of negative physical and mental health outcomes, with cortisol dysregulation implicated as a possible mechanism. Given inconsistencies across in the literature regarding the direction and magnitude of the association between maltreatment and diurnal cortisol regulation, the curre...

journal_title：Psychoneuroendocrinology

authors： Bernard K,Frost A,Bennett CB,Lindhiem O

更新日期：2017-04-01 00:00:00

abstract：:Sex steroids exert important organizational effects on brain structure. Early in life, they are involved in brain sexual differentiation. During puberty, sex steroid levels increase considerably. However, to which extent sex steroid production is involved in structural brain development during human puberty remains un...

journal_title：Psychoneuroendocrinology

authors： Peper JS,Brouwer RM,Schnack HG,van Baal GC,van Leeuwen M,van den Berg SM,Delemarre-Van de Waal HA,Boomsma DI,Kahn RS,Hulshoff Pol HE

更新日期：2009-04-01 00:00:00

abstract：:A number of studies have now examined the association between smoking and the magnitude of physiological reactions to acute psychological stress. However, no large-scale study has demonstrated this association incorporating neuroendocrine in addition to cardiovascular reactions to stress. The present study compared ne...

journal_title：Psychoneuroendocrinology

authors： Ginty AT,Jones A,Carroll D,Roseboom TJ,Phillips AC,Painter R,de Rooij SR

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Recent data suggest that ghrelin is involved in the pathophysiology of alcohol use disorders, affecting alcohol self-administration and craving. Gastric ghrelin secretion is reduced by stomach distension. We now tested the hypothesis whether the clinically well-known effects of high-volume water intake on cr...

journal_title：Psychoneuroendocrinology

authors： Koopmann A,Lippmann K,Schuster R,Reinhard I,Bach P,Weil G,Rietschel M,Witt SH,Wiedemann K,Kiefer F

更新日期：2017-11-01 00:00:00

abstract：:Chronic stress contributes to many neuropsychiatric disorders in which the HPA axis, cognition and neuro-immune activity are dysregulated. Patients with major depression, or healthy individuals subjected to acute stress, present elevated levels of circulating pro-inflammatory markers. Acute stress also activates pro-i...

journal_title：Psychoneuroendocrinology

authors： Girotti M,Donegan JJ,Morilak DA

更新日期：2011-09-01 00:00:00

abstract：:This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice. Single intraperi...

journal_title：Psychoneuroendocrinology

authors： Tutka P,Mróz K,Mróz T,Buszewicz G,Aebisher D,Bartusik-Aebisher D,Kołodziejczyk P,Łuszczki JJ

更新日期：2019-03-01 00:00:00