Abstract：
BACKGROUND:The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acute exercise compared to healthy controls. Secondly, we aimed to assess the effect of antidepressants on NT-proANP response to acute exercise. METHODS:We examined 132 outpatients with mild to moderate depression (ICD-10) and 44 healthy controls, group matched for age, sex, and BMI. We used an incremental bicycle ergometer test as a physical stressor. Blood samples were drawn at rest, at exhaustion, and 15, 30, and 60 min post-exercise. RESULTS:The NT-proANP response to physical exercise differed between depressed subjects and healthy controls (group×time; F(4,162.9)=10.92; p<0.001). The increase from rest to VO(2max) was 0.98 (SD 0.8) and 1.96 nmol/l (SD 1.1), respectively, for depressed subjects and healthy controls (mean diff: 0.98 nmol/l; 95% CI 0.7-1.3; t=6.63; df=170; p<0.001). The increase in NT-proANP from rest to peak VO(2max) was 1.27 (SD 1.0) and 0.84 nmol/l (SD 0.6), respectively, for unmedicated and medicated patients (mean diff: 0.42 nmol/l; 95% CI 0.1-0.8; t=2.56; df=128; p=0.01). CONCLUSION:We observed an attenuated NT-proANP response to acute physical stress in depressed patients. Antidepressants were associated with an independent suppressive effect on the NT-proANP response.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Krogh J,Ströhle A,Westrin A,Klausen T,Jørgensen MB,Nordentoft Mdoi
10.1016/j.psyneuen.2010.09.009subject
Has Abstractpub_date
2011-06-01 00:00:00pages
656-63issue
5eissn
0306-4530issn
1873-3360pii
S0306-4530(10)00242-8journal_volume
36pub_type
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