State associations with the cortisol awakening response in healthy females.

Abstract:

:The current study examined intra-individual relationships between the cortisol awakening response (CAR) and state sleep-related and psychosocial variables in a pooled design study. 12 healthy female participants (age range: 22-41 years.) were examined on 12 study days each, occurring at three-day intervals. Quantitative diaries capturing state sleep-related and psychosocial variables were filled out on the evening before each study day as well as 45 min post-awakening on the study day. On each study day, salivary free cortisol was determined at 0, 15, 30, and 45 min post-awakening. Relationships between cortisol measures and psychosocial variables were analysed using dummy-variable linear regression models. State variability in the CAR (area under increase curve; AUC(I)) was found to be inversely related to simultaneous variability in awakening time (beta=-.29, p<.005) and positively related to variability in adverse psychosocial states of stress (beta=.22, p<.01) and tension (beta=.32, p<.001) measured 45 min post-awakening. In addition, levels of the CAR were also found to decrease linearly over the study period across participants (beta=-.19, p<.01) and this time trend could not be explained through a relationship between the CAR and any of the examined variables. The results are discussed within the context of previous evidence and potential implications for cross-sectional research are highlighted.

journal_title

Psychoneuroendocrinology

authors

Stalder T,Evans P,Hucklebridge F,Clow A

doi

10.1016/j.psyneuen.2010.02.014

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

1245-52

issue

8

eissn

0306-4530

issn

1873-3360

pii

S0306-4530(10)00059-4

journal_volume

35

pub_type

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