Abstract:
:Females have a higher prevalence than men of neuropsychiatric disorders in which dopaminergic abnormalities play a prominent role, e.g. very late-onset schizophrenia and Parkinson's disease (PD). The biological basis of these sex differences is unknown but may include modulation of the dopaminergic system by sex hormones, as there is preliminary evidence that estrogen modulates treatment response in these disorders. Furthermore, sex differences in dopamine-mediated cognitive decline suggest estrogen may also play a role in healthy aging. However, the effects of estrogen on the dopaminergic system are poorly understood, and nobody has examined the effect of long-term estrogen therapy (ET) on this system. We compared dopaminergic responsivity (growth hormone (GH) response to apomorphine) in post-menopausal women on ET to women who were ET-naïve. GH response to subcutaneous apomorphine (0.005 mg/kg) was measured in two groups of healthy post-menopausal women aged between 55 and 70 years: those taking ET (n = 13) and those who had never taken ET (n = 13). Neither group was taking any other medication. GH was measured at 15 min intervals from -30 min before administration of apomorphine to 90 min post-administration. GH response was measured in two ways: area under the curve (AUC) and maximum response over baseline (GH). There were no between-group differences in demographic or baseline variables. The ET treated women had a significantly greater (p = 0.03) AUC than ET naïve women (mean +/- S.D.; 5.3 +/- 4.7 vs. 2.6 +/- 2.3). However, (GH) did not differ significantly between groups (6.1 mU/l +/- 6.2 vs. 2.7 mU/l +/- S.D. = 4.1). Also, analysis of GH response over time revealed a significant main effect of time (p < 0.0005), and a group by time interaction (p = 0.004) , but no significant main effect of group. Our results suggest that ET may enhance dopaminergic responsivity in post-menopausal women. Estrogen deficiency following menopause may partly explain age and gender differences in late-onset neuropsychiatric disorders.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Craig MC,Cutter WJ,Wickham H,van Amelsvoort TA,Rymer J,Whitehead M,Murphy DGdoi
10.1016/j.psyneuen.2004.03.008keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1309-16issue
10eissn
0306-4530issn
1873-3360pii
S0306453004000484journal_volume
29pub_type
临床试验,杂志文章abstract:BACKGROUND:Hypopituitary patients with growth hormone deficiency (GHD) complain of reduced vitality, general fatigue, lack of concentration, irritability and reduced alertness during daytime. It is unclear whether these symptoms are primarily due to GH-deficiency and/or secondary to GHD related sleep impairments. Bi-di...
journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2004.05.004
更新日期:2005-01-01 00:00:00
abstract::This study aimed to: (1) evaluate food craving and high-sweet-fat food craving across the menstrual cycle; (2) compare the craving and explicit/implicit emotional response to different food; and (3) investigate the reward sensitivity among PMDD and control groups. The PMDD group without treatment history and control g...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2010.02.006
更新日期:2010-09-01 00:00:00
abstract::Individuals who poorly regulate emotion exhibit premature aging and worse general health. Telomere shortening, a prognostic biomarker of physical health, is related to aging, poor immunocompetence and autonomic nervous system functioning. Cognitive reappraisal is one type of emotion regulation strategy, which involves...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.104517
更新日期:2020-02-01 00:00:00
abstract::Epidemiological data suggest that omega-3 polyunsaturated fatty acids (PUFA) consumption may be inversely correlated to the prevalence and severity of depression but little is known about the underlying mechanisms. In this study, we experimentally investigated whether a chronic supplementation with PUFA may induce ant...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2008.08.025
更新日期:2009-02-01 00:00:00
abstract::The evolution of the autonomic nervous system provides an organizing principle to interpret the adaptive significance of mammalian affective processes including courting, sexual arousal, copulation, and the establishment of enduring social bonds. According to the Polyvagal Theory (Porges, 1995, 1996, 1997), the well-d...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/s0306-4530(98)00057-2
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:Cognitive behavioral stress management (CBSM) is an empirically-validated group-based psychosocial intervention. CBSM is related to decreased self-reported indicators of psychological adversity during breast cancer treatment and greater disease-free survival (DFS) vs. a control condition. This study examined re...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2016.09.012
更新日期:2016-12-01 00:00:00
abstract::The aim of this research was study the role of psychosocial factors in exacerbations of asthma in adults induced by upper respiratory tract infections (URTIs). It involved a longitudinal study (one year) of 92 adults with asthma. The volunteers were 27 men and 65 women 19-46 years of age with a mean duration of wheeze...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/s0306-4530(00)00063-9
更新日期:2001-05-01 00:00:00
abstract::The hypothalamo-pituitary-adrenal (HPA) axis is hyperactive in major depressive disorder (MDD), and baseline cortisol levels are usually elevated in MDD patients, with alterations of the circadian hormone secretion pattern. The dexamethasone (DEX) suppression test (DST) has been extensively applied to diagnose a dysre...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2007.03.012
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF level...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.12.015
更新日期:2017-03-01 00:00:00
abstract::Testosterone concentrations rise rapidly in the context of competitive interactions and remain elevated in winners relative to losers. Theoretical models suggest that this divergent neuroendocrine response serves to mediate future dominance behaviours. Although research in animal models provides compelling support for...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2013.03.008
更新日期:2013-10-01 00:00:00
abstract::Individual differences in the activity of the hypothalamic pituitary adrenal (HPA) axis are often operationalized using summary measures of cortisol that are taken to represent stable individual differences. Here we extend our understanding of a novel latent variable approach to latent trait cortisol (LTC) as a measur...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2015.08.009
更新日期:2015-12-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2014.10.018
更新日期:2015-01-01 00:00:00
abstract::Stress causes activation of the hypothalamic-pituitary-adrenal (HPA) axis and results in the secretion of corticosteroids, which facilitate behavioral adaptation and promote the termination of the stress response. These actions exerted by cortisol are mediated by two brain corticosteroid receptor types: the high affin...
journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/j.psyneuen.2009.07.006
更新日期:2010-04-01 00:00:00
abstract::Arginine Vasopressin modulates complex social and sexual behavior by enhancing social recognition, pair bonding, and aggression in non-human mammals. The influence of Arginine Vasopressin in human social and sexual behavior is, however, yet to be fully understood. We evaluated whether Arginine Vasopressin nasal spray ...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2010.07.023
更新日期:2011-02-01 00:00:00
abstract::There is now an expanding volume of evidence to support the view that commensal organisms within the gut play a role in early programming and later responsivity of the stress system. The gut is inhabited by 10¹³-10¹⁴ micro-organisms, which is ten times the number of cells in the human body and contains 150 times as ma...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.psyneuen.2012.03.007
更新日期:2012-09-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2015.02.001
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:Exposure to adversity has been linked to accelerated biological aging, which in turn has been shown to predict numerous physical and mental health problems. In recent years, measures of DNA methylation-based epigenetic age--known as "epigenetic clocks"--have been used to estimate accelerated epigenetic aging...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.104484
更新日期:2020-03-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2010.04.009
更新日期:2010-11-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.104543
更新日期:2020-03-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.07.219
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Our laboratory has previously reported that testosterone (T) administration to older men significantly improves cognitive function. This study examined potential changes in insulin-like growth factor (IGF) IGF-I, IGF-II and IGF-related binding proteins in response to T administration in older men and their r...
journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0306-4530(02)00136-1
更新日期:2004-01-01 00:00:00
abstract::Sociality is a fundamental aspect of human behavior and health. One benefit of affiliative social relationships is reduced short-term levels of glucocorticoids (GCs), which are indicative of physiological stress. Less is known, however, about chronic GC production in relation to affiliative social behavior. To address...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2017.06.018
更新日期:2017-10-01 00:00:00
abstract::In the female rat, stimulation of the uterine cervix (CS) during mating or by artificial means induces daily diurnal and nocturnal surges in prolactin (PRL) secretion which, in the absence of fertilization, result in an 12-day anestrous period called pseudopregnancy (PSP). The amount or type of mating stimulation rece...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(94)90016-7
更新日期:1994-01-01 00:00:00
abstract::Anticipation may play a role in shaping biological reactions to repeated stressors-a common feature of modern life. We aimed to demonstrate that: (a) individuals who display a larger cortisol response to an initial stressor exhibit progressive anticipatory sensitization, showing progressively higher cortisol levels be...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2014.11.014
更新日期:2015-02-01 00:00:00
abstract::In addition to its classical growth hormone (GH) inhibiting action, somatostatin (SRIF) inhibits prolactin (PRL) secretion in man and rat under specific endocrine conditions. Furthermore, SRIF counteracts the thyrotropin releasing hormone (TRH) and vasoactive intestinal peptide (VIP) stimulated prolactin release from ...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(86)90050-8
更新日期:1986-01-01 00:00:00
abstract::Using percutaneously placed arterial and venous catheters, we examined the influence of aging on the plasma concentration, whole body production rate, and renal clearance of homovanillic acid (HVA) in 60 healthy adult volunteers. The arterio-renal fractional extraction of HVA combined with the renal plasma flow (Fick ...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(94)90057-4
更新日期:1994-01-01 00:00:00
abstract::Adolescent animals are vulnerable to the effects of stress on brain development. We hypothesized that long-term effects of adolescent chronic stress are mediated by glucocorticoid receptor (GR) signaling. We used a specific GR modulator (CORT108297) to pharmacologically disrupt GR signaling in adolescent rats during e...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.104490
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:A proportion of patients with panic disorder (PD) fail to show a remission after psychotherapy. Biological correlates of psychotherapy non-response have rarely been described in the literature. The aim of the present study was to research the relationship between the cortisol stress response and the psychoth...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.11.030
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:Maternal obesity and a disturbed metabolic environment during pregnancy and lactation have been shown to result in many long-term health consequences for the offspring. Among them, impairments in neurocognitive development and performance belong to the most dreaded ones. So far, very few mechanistic approache...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2017.12.023
更新日期:2018-03-01 00:00:00
abstract:INTRODUCTION:During pregnancy, maternal stressors cause changes in both maternal and fetal HPA axes. We therefore investigated the impact of maternal non chronic and chronic stress on fetal glucose metabolism and growth, and serum levels of cortisol in the fetus. MATERIALS AND METHODS:Normal weight pregnant women (n =...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.104591
更新日期:2020-04-01 00:00:00