Abstract:
:Sequential exposure to stressors may elicit a period of endocrine hyperresponsiveness during which plasma hormone concentrations reach higher levels after repeated exposure to a stressor compared to levels after initial exposure. The present study was designed to further characterize hyperresponsiveness to repeated stress and determine if hyperresponsiveness is dependent upon repeated exposure to the same stressful stimuli. In Experiment 1, rats were stressed by inescapable tailshock, immobilization or exposure to shock chamber without shock for one, two, three, four or five consecutive days (15 min/day). In rats exposed to tailshock, corticosterone (CS) levels in plasma collected on days 2, 3, 4 and 5 were higher than CS levels following acute tailshock on day 1, demonstrating hyperresponsiveness to repeated tailshock. Hyperresponsiveness of CS secretion also occurred in groups of rats restrained for four or five days. No changes occurred in the CS response of animals repeatedly exposed to immobilization. Prolactin (PRL) levels were not affected by repeated exposure to the stressors. However, PRL values were different between the stress conditions and indicated that the order of stressor severity was tailshock greater than immobilization greater than exposure to shock chamber without shock. In Experiment 2, rats were exposed to either one or two consecutive days of tailshock or immobilization. Other rats were exposed to either tailshock or immobilization on the first day, then switched to the other stressor on the next day. Hyperresponsiveness to repeated tailshock, but not immobilization, was reflected in plasma levels of CS and adrenocorticotropic hormone (ACTH), but not PRL. Hyperresponsiveness of CS and ACTH secretion also was found in rats first stressed by immobilization then switched to tailshock, demonstrating that hyperresponsiveness is not dependent upon reexposure to familiar stressful stimuli. However, hyperresponsiveness did not occur in rats first exposed to tailshock then switched to immobilization. The data suggest that both immobilization and tailshock primed the organism to hyperrespond, but only the more severe stressor (tailshock) elicited hyperresponsiveness of the neuroendocrine system.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Orr TE,Meyerhoff JL,Mougey EH,Bunnell BNdoi
10.1016/0306-4530(90)90057-gsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
317-28issue
5-6eissn
0306-4530issn
1873-3360journal_volume
15pub_type
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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pub_type: 杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/j.psyneuen.2004.11.005
更新日期:2005-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2008.09.006
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journal_title:Psychoneuroendocrinology
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-02-01 00:00:00
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doi:10.1016/j.psyneuen.2019.05.011
更新日期:2019-09-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(93)90016-e
更新日期:1993-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.104543
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(90)90033-6
更新日期:1990-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(86)90032-6
更新日期:1986-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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更新日期:2014-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
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更新日期:2006-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2013.09.011
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.11.008
更新日期:2012-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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