Abstract:
:Type 2 diabetes (T2D) has been associated with cognitive decline, dementia and Alzheimer's disease (AD). Remarkably, the pathophysiological mechanisms behind this are still mostly unknown. Cognition and memory formation are associated with gamma oscillations in hippocampal neuronal networks and fast-spiking, parvalbumin-expressing interneurons (PV+ IN) play a key role in these processes.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Lietzau G,Darsalia V,Pintana H,Östenson CG,Nyström T,Fisahn A,Patrone Cdoi
10.1016/j.psyneuen.2017.04.012subject
Has Abstractpub_date
2017-08-01 00:00:00pages
46-50eissn
0306-4530issn
1873-3360pii
S0306-4530(17)30181-6journal_volume
82pub_type
杂志文章abstract::Attention-deficit/hyperactivity disorder (ADHD) is one of the most common child psychiatric disorders. Previous studies have reported a blunted cortisol response to challenging situations and a decreased cortisol awakening response (CAR) in children with ADHD. As ADHD often is comorbid with oppositional defiant disord...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2009.01.018
更新日期:2009-08-01 00:00:00
abstract::The diurnal rhythm of cortisol secretion in chronic disease can reflect the interactions between exogenous and endogenous factors. Exogenous glucocorticoid use may impact salivary cortisol measurements, but this has not been well-studied in ambulatory settings. In this report salivary cortisol levels were used to eval...
journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/j.psyneuen.2005.03.003
更新日期:2005-09-01 00:00:00
abstract::The hypothalamo-pituitary-adrenal (HPA) axis is hyperactive in major depressive disorder (MDD), and baseline cortisol levels are usually elevated in MDD patients, with alterations of the circadian hormone secretion pattern. The dexamethasone (DEX) suppression test (DST) has been extensively applied to diagnose a dysre...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2007.03.012
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Chronic psychosocial stress is a crucial risk factor in the development of many diseases including obesity. Neuropeptide Y (NPY), distributed throughout the peripheral and central nervous system, is believed to pay a role in the pathophysiologic relationship between stress and obesity. Although several anima...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.03.003
更新日期:2016-07-01 00:00:00
abstract::Decline in the ovarian steroid, estradiol (E(2)), with the menopause transition may influence cognitive and affective processing of older women and there is evidence that hormone replacement therapies (HRTs) with E(2)-mimetics may provide benefit in some, but not all, women. The parameters that play a role in determin...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2009.01.004
更新日期:2009-07-01 00:00:00
abstract::Determinations of gonadotropins and testosterone were performed in 22 men with hypospadias (H), seven male-to-female transsexuals (T) and in 16 normal men (N), all of similar age. The response of serum FSH and LH to GnRH was determined in six subjects in each group. Oligospermia was found in five of 13 patients with H...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(86)90032-6
更新日期:1986-01-01 00:00:00
abstract::We have repeated a study of the objective (labium minus temperature) and subjective (semantic scales) changes in sexual arousability over the menstrual cycle to erotic video stimulation in 20 women with natural cycles. We extended the study with concomitant vibrotactile stimulation of the clitoral region. In an earlie...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(95)00058-5
更新日期:1996-08-01 00:00:00
abstract:UNLABELLED:Long-term opioid therapy has been associated with low cortisol levels due to central suppression of the hypothalamic-pituitary-adrenal axis. The implications of hypocortisolism on wellbeing have not been established. Our aim was to determine whether intervention with physiologic glucocorticoid replacement th...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2015.03.015
更新日期:2015-06-01 00:00:00
abstract::Data from animal studies suggest that oxytocin is an important modulating neuropeptide in regulation of social interaction. One human study has reported a negative correlation between CSF oxytocin levels, life history of aggression and suicidal behaviour. We hypothesized that CSF oxytocin levels would be related to su...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.07.016
更新日期:2012-04-01 00:00:00
abstract::It is well established that a reciprocal control exists between the brain and glucocorticoid hormones. The brain regulates adrenocortical function via hypothalamic corticotrophin releasing hormone-41 (CRH-41), glucocorticoids act at specific receptors in the hippocampus, thus promoting negative feedback mechanisms. Be...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/0306-4530(92)90040-e
更新日期:1992-08-01 00:00:00
abstract::Chronic stress contributes to many neuropsychiatric disorders in which the HPA axis, cognition and neuro-immune activity are dysregulated. Patients with major depression, or healthy individuals subjected to acute stress, present elevated levels of circulating pro-inflammatory markers. Acute stress also activates pro-i...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.02.008
更新日期:2011-09-01 00:00:00
abstract::The objective of the present study is to synthesize the existing empirical literature and perform a meta-analysis of published data on the relationship between cortisol and telomere length. We systematically searched studies that examined the relationship between cortisol and telomere length in humans on electronic da...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,meta分析
doi:10.1016/j.psyneuen.2019.01.022
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Hypothalamus-Pituitary-Adrenal (HPA) axis dysregulation is often seen in major depression, and is thought to represent a trait vulnerability - rather than merely an illness marker - for depressive disorder and possibly anxiety disorder. Vulnerability traits associated with stress-related disorders might refl...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2010.07.014
更新日期:2011-02-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) is a stress-related mental disorder which occurs following exposure to traumatic events. A number of brain neuroimaging studies have revealed that PTSD patients have reduced volume and abnormal functions in the hippocampus and the amygdala. However, the pathogenesis of abnormaliti...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.psyneuen.2018.05.015
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Leptin (LEP) is a hormone central for energy homeostasis and has been implicated in neurodevelopment. This adipokine is produced by the placenta and is epigenetically regulated by promoter DNA methylation. Recent evidence has suggested a role for LEP in behavioral development. In this study, we investigated ...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2013.10.012
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Flibanserin, a novel serotonin (5-HT)(1A) agonist and 5-HT(2A) antagonist, has been shown to increase sexual desire and reduce distress in women with Hypoactive Sexual Desire Disorder (HSDD). In marmoset monkeys, flibanserin has demonstrated pro-social effects on male-female pairmates, while the classic 5-HT...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.05.011
更新日期:2013-01-01 00:00:00
abstract::Brain oxytocin and dopamine systems interact to modulate social cognitive behavior. Whether the interactions are modulated by oxytocin receptor (OXTR) gene variations remains unclear. Considering the dopamine transporter (DAT) availability as an endophenotype and the degree of dopamine-mediated neuroticism as a phenot...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2014.05.020
更新日期:2014-09-01 00:00:00
abstract::The μ opioid receptor (MOR) in the nucleus accumbens (NAc) is involved in assigning pleasurable, or hedonic value to rewarding stimuli. Importantly, the hedonic value of a given rewarding stimulus likely depends on an individual's current motivational state. Here, we examined the involvement of MORs in the motivation ...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2017.12.017
更新日期:2018-03-01 00:00:00
abstract::The possible participation of the endogenous opioid system (EOS) in the negative feedback of the hypothalamic-pituitary-adrenal axis (HPA-a) activated by low doses (1 mg) of dexamethasone (Dex) was investigated. Ten male healthy subjects (mean age 31.5 +/- 1.9 SEM) were studied on 2 separate days, in a double-blind, c...
journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0306-4530(98)00002-x
更新日期:1998-05-01 00:00:00
abstract::Neurobehavioral symptoms are frequently reported in patients with diabetes. Nevertheless, the characterization of the specific symptom dimensions that develop in diabetic patients with respect to disease phenotype and treatment status remains obscure. This study comparatively assessed fatigue symptoms and cognitive pe...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.01.016
更新日期:2012-09-01 00:00:00
abstract::The neuropeptides thyrotropin releasing hormone (TRH) and prolactin (PRL), which affect various behaviors in animals, showed "antidepressant" properties in an experimental model of depression. Subcutaneous administration of TRH reduced the total immobility time of rats tested in the despair (constrained swim) test and...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(90)90060-m
更新日期:1990-01-01 00:00:00
abstract::Developmental language and learning disabilities in children can take many different forms and can result from a variety of causes. Research to date has focused primarily on specific disabilities in learning, which are characterized by a significant delay or disorder in one aspect of learning against a background of o...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/0306-4530(91)90079-9
更新日期:1991-01-01 00:00:00
abstract::Antidepressants affect glucocorticoid receptor (GR) functioning partly through modulation of its phosphorylation but their effects on mitochondrial GR have remained undefined. We investigated the ability of chronic fluoxetine treatment to affect chronic stress-induced changes of mitochondrial GR and its phosphoisoform...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2013.07.019
更新日期:2013-12-01 00:00:00
abstract:CONTEXT:Affective symptoms are poorly understood in polycystic ovary syndrome (PCOS). Clinical signs of hyperandrogenism and high serum androgens are key features in PCOS, and women with PCOS are more likely to be overweight or obese, as well as insulin resistant. Further, PCOS is associated with high sympathetic nerve...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.04.001
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Raised maternal anxiety during pregnancy is associated with increased risk of adverse neurodevelopmental outcomes for her child. The mechanisms underlying this are not known but animal studies suggest prenatal stress may alter the function of the placenta. Here we determined whether maternal prenatal anxiety...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.09.014
更新日期:2012-06-01 00:00:00
abstract::The current study investigates the effect of a single episode of acute social stress on healthy children's processing of facial expressions of emotion. Healthy nine- and ten-year-old boys (N=39) underwent either a standardized psychosocial laboratory stressor (the Trier Social Stress Test for Children) or a control co...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2013.11.003
更新日期:2014-02-01 00:00:00
abstract::Stress and inflammation are both important risk factors for coronary artery disease (CAD). However, the susceptibility to stress-induced inflammation and its determinants have been little explored in patients with CAD. Here, our aim was to study the stress-induced inflammatory response, more precisely the early releas...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.07.219
更新日期:2016-11-01 00:00:00
abstract::Recent studies have demonstrated alterations in the cortisol awakening response (CAR) and brain abnormalities in adults with obesity and type 2 diabetes mellitus (T2DM). While adolescents with T2DM exhibit similar brain abnormalities, less is known about whether brain impairments and hypothalamic-pituitary-adrenal (HP...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.12.020
更新日期:2012-08-01 00:00:00
abstract::Recent evidence suggests that testosterone is negatively correlated with empathic processes in both men and women. Also, administration of testosterone to young women impairs socio-cognitive performance as assessed using the "Reading the Mind in the Eyes Task", especially among those exposed to elevated testosterone c...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2015.08.023
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Childhood adversity is a robust predictor of poor health outcomes in adulthood and hypothalamic-pituitary-adrenocortical (HPA) axis dysfunction may be a key mechanism explaining this association. However, little is known about the influence childhood adversity may exhibit on adult HPA axis habituation (i.e.,...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.105118
更新日期:2020-12-24 00:00:00