Abstract：
:Data from animal studies suggest that oxytocin is an important modulating neuropeptide in regulation of social interaction. One human study has reported a negative correlation between CSF oxytocin levels, life history of aggression and suicidal behaviour. We hypothesized that CSF oxytocin levels would be related to suicidal behaviour, suicide intent, lifetime interpersonal violence and suicide risk. 28 medication free suicide attempters and 19 healthy volunteers participated in this cross sectional and longitudinal study. CSF and plasma morning basal levels of oxytocin were assessed with specific radio-immunoassays. The Beck Suicide Intent Scale (SIS), the Freeman scale and the Karolinska Interpersonal Violence Scale (KIVS) were used to assess suicide intent and lifetime violent behaviour. All patients were followed up for cause of death. The mean follow-up was 21 years. Suicide attempters had lower CSF oxytocin levels compared to healthy volunteers p=0.077. In suicide attempters CSF oxytocin showed a significant negative correlation with the planning subscale of SIS. CSF oxytocin showed a significant negative correlation with suicide intent, the planning subscale of SIS and Freeman interruption probability in male suicide attempters. Correlations between plasma oxytocin levels and the planning subscale of SIS and Freeman interruption probability were significant in male suicide attempters. Lifetime violent behaviour showed a trend to negative correlation with CSF oxytocin. In the regression analysis suicide intent remained a significant predictor of CSF oxytocin corrected for age and gender whereas lifetime violent behaviour showed a trend to be a predictor of CSF oxytocin. Oxytocin levels did not differ significantly in suicide victims compared to survivors. CSF oxytocin may be an important modulator of suicide intent and interpersonal violence in suicide attempters.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Jokinen J,Chatzittofis A,Hellström C,Nordström P,Uvnäs-Moberg K,Asberg Mdoi
10.1016/j.psyneuen.2011.07.016subject
Has Abstractpub_date
2012-04-01 00:00:00pages
482-90issue
4eissn
0306-4530issn
1873-3360pii
S0306-4530(11)00231-9journal_volume
37pub_type
杂志文章abstract：:This study aimed to examine how loneliness contributes to metabolic dysregulation among older adults with depression and determine the relative contribution of loneliness to the development of chronic diseases in late adulthood. Harmonised data from the Ageing Trajectories of Health: Longitudinal Opportunities and Syn...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.104918
更新日期：2021-01-01 00:00:00
abstract：:Circulating cortisol levels are known to influence explicit memory in humans and other primates. The present study investigated salivary cortisol and its association with explicit memory performance in 99 postmenopausal women (64 treated with conjugated equine estrogens or estradiol, and 35 matched controls not using ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.11.009
更新日期：2016-02-01 00:00:00
abstract：:The bed nucleus of the stria terminalis (BNST) plays a critical role in fear and anxiety. The BNST is important for contextual fear learning, but the mechanisms regulating this function remain unclear. One candidate mechanism is corticotropin-releasing-factor (CRF) acting at CRF type 1 receptors (CRFr1s). Yet, there h...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.04.021
更新日期：2016-08-01 00:00:00
abstract：:Corticotropin-releasing factor (CRF), a 41 amino acid polypeptide, has been isolated from ovine hypothalamic extracts, sequenced, and synthesized. It has a high potency for stimulating the secretion of corticotropin-like and beta-endorphin-like immunoactive substances in vitro and in vivo in laboratory animals and hum...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/0306-4530(86)90014-4
更新日期：1986-01-01 00:00:00
abstract：:The main methodological issues that should be considered in studies of premenstrual changes are discussed. They include: the selection of well-defined groups of subjects who reflect the diversity of subtypes of premenstrual changes (PMC); the confirmation of retrospective reports through daily monitoring of changes by...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(85)90036-8
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity has been observed in (recurrent) major depressive disorder (MDD), although inconsistently and mainly cross-sectional. Longitudinal studies clarifying state-trait issues are lacking. We aimed to determine whether HPA-axis (hyper)activity in recurrent MDD...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2011.10.005
更新日期：2012-07-01 00:00:00
abstract：:The objective of the present study is to synthesize the existing empirical literature and perform a meta-analysis of published data on the relationship between cortisol and telomere length. We systematically searched studies that examined the relationship between cortisol and telomere length in humans on electronic da...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,meta分析
doi：10.1016/j.psyneuen.2019.01.022
更新日期：2019-05-01 00:00:00
abstract：:Gene expression of phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing conversion of norepinephrine to epinephrine, has been detected in rat spleen using the reverse transcription polymerase chain reaction. PNMT identity was subsequently verified by Southern blots. Localization of the spleen cells res...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(01)00098-1
更新日期：2002-07-01 00:00:00
abstract：:Cortisol, the primary glucocorticoid (GC) in humans, influences neuronal excitability and plasticity by acting on mineralocorticoid and glucocorticoid receptors. Cellular studies demonstrated that elevated GC levels affect neuronal plasticity, for example through a reduction of hippocampal long-term potentiation (LTP)...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2016.12.002
更新日期：2017-03-01 00:00:00
abstract：:Vagal activity - reflecting the activation of stress regulatory mechanisms and prefrontal cortex activation - is thought to play an inhibitory role in the regulation of the hypothalamus-pituitary-adrenal axis. However, most studies investigating the association between stress-induced changes in heart rate variability ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2018.05.004
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their assoc...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.psyneuen.2014.09.025
更新日期：2015-01-01 00:00:00
abstract：:The translocator protein 18 kDa (TSPO), initially characterized as peripheral benzodiazepine receptor, is a conserved outer mitochondrial membrane protein, implicated in cholesterol transport thereby affecting steroid hormone biosynthesis, as well as in general mitochondrial function related to bioenergetics, oxidativ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.03.029
更新日期：2019-08-01 00:00:00
abstract：:Executive function is defined as a set of cognitive skills that are necessary to plan, monitor, and execute a sequence of goal-directed complex actions. Executive function is influenced by a variety of factors, including habitual sleep duration and diabetes. In the present study, we investigated in 18,769 Swedish adul...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.104472
更新日期：2020-01-01 00:00:00
abstract：:A number of studies have now examined the association between smoking and the magnitude of physiological reactions to acute psychological stress. However, no large-scale study has demonstrated this association incorporating neuroendocrine in addition to cardiovascular reactions to stress. The present study compared ne...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2014.05.023
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Chronic psychosocial stress is a crucial risk factor in the development of many diseases including obesity. Neuropeptide Y (NPY), distributed throughout the peripheral and central nervous system, is believed to pay a role in the pathophysiologic relationship between stress and obesity. Although several anima...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.03.003
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with de...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2010.09.009
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:No simple way to augment fear extinction has been established. Cortisol has shown to enhance memory extinction and preliminary evidence suggest that extinction learning maybe more successful in the morning when cortisol is high. The aim was to determine whether exposure sessions conducted earlier in the day a...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.09.008
更新日期：2016-12-01 00:00:00
abstract：:Antidepressants such as SSRIs or mirtazapine have been demonstrated to increase the concentrations of 3alpha-reduced neuroactive steroids throughout several weeks of treatment. However, no data are available on the impact of mood stabilizers such as lithium or carbamazepine on neuroactive steroid levels in depressed p...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.04.004
更新日期：2007-07-01 00:00:00
abstract：:Behavioral data suggest that fear stimuli automatically activate fear and capture attention. This effect is likely to be mediated by a subcortical brain network centered on the amygdala. Consistent with this view, brain imaging studies show that masked facial stimuli activate the amygdala as do masked pictures of thre...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2005.03.019
更新日期：2005-11-01 00:00:00
abstract：:Diabetes is a highly prevalent, chronic disease that requires ongoing, multi-specialty medical care combined with patient self-management, family support, and education to prevent or delay end-organ morbidity and mortality. There is clearly an increased prevalence of major depressive disorder, a relatively common and ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2011.03.005
更新日期：2011-10-01 00:00:00
abstract：:The nature of hormonal involvement in pubertal brain development has attracted wide interest. Structural changes within the brain that occur during pubertal development appear mainly in regions closely linked with emotion, motivation and cognitive functions. Using a sheep model, we have previously shown that peri-pube...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.09.011
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVES:Suicide is a global health issue. Dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity, as measured by cortisol levels, has been identified as one potential risk factor for suicide. Recent evidence has indicated that blunted cortisol reactivity to stress is associated with suicidal behavior. The c...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2017.11.004
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Delay discounting as a measure of impulsivity has been shown to be higher in obesity with an association of increased food intake. Moreover, obese humans showed a higher wanting for high-calorie food than lean men when blood glucose concentrations were low. First studies linking blood glucose levels to delay...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2018.01.014
更新日期：2018-03-01 00:00:00
abstract：:Caffeine is a commonly used psychoactive substance and consumption by children and adolescents continues to rise. Here, we examine the lasting effects of adolescent caffeine consumption on anxiety-related behaviors and several neuroendocrine measures in adulthood. Adolescent male Sprague-Dawley rats consumed caffeine ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.01.030
更新日期：2016-05-01 00:00:00
abstract：:We have repeated a study of the objective (labium minus temperature) and subjective (semantic scales) changes in sexual arousability over the menstrual cycle to erotic video stimulation in 20 women with natural cycles. We extended the study with concomitant vibrotactile stimulation of the clitoral region. In an earlie...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(95)00058-5
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Although the linkage between psychological stress and cortisol is believed to mediate the association of stress with health outcomes, several studies have been unable to demonstrate this association. We suggest this inability may be a consequence of limitations in the measurement approach and/or reliance on ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.104848
更新日期：2020-11-01 00:00:00
abstract：:Sensitization is defined as a non-associative learning process occurring when repeated administrations of a stimulus result in a progressive amplification of a response (Shettleworth, 2010). The purpose of this review paper is to discuss whether brain sensitization is helpful in common health problems in man. The pape...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2014.01.008
更新日期：2014-04-01 00:00:00
abstract：:The present study examined how the interplay of partners' attachment styles influences cortisol response, actual closeness, and desired closeness during friendship initiation. Participants provided salivary cortisol samples at four timepoints throughout either a high or low closeness task that facilitated high or low ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2017.03.009
更新日期：2017-06-01 00:00:00
abstract：:This article presents a review of the neural and neurochemical regulation of maternal behavior in the rat, emphasizing the role of the medial preoptic area (MPOA) and its neural connections in this regulation. Evidence for the role of the MPOA includes the following and will be discussed: (1) Axon-sparing lesions of t...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/0306-4530(88)90006-6
更新日期：1988-01-01 00:00:00
abstract：:In the field of depression, inflammation-associated depression stands up as an exception since its causal factors are obvious and it is easy to mimic in an animal model. In addition, quasi-experimental studies can be carried out in patients who are treated chronically with recombinant cytokines for a medical condition...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2010.09.012
更新日期：2011-04-01 00:00:00
