Abstract：
:Corticotropin-releasing factor (CRF), a 41 amino acid polypeptide, has been isolated from ovine hypothalamic extracts, sequenced, and synthesized. It has a high potency for stimulating the secretion of corticotropin-like and beta-endorphin-like immunoactive substances in vitro and in vivo in laboratory animals and humans. The high concentration of CRF-like immunoactivity in hypophyseal portal plasma supports the hypothesis that CRF is the physiological hypothalamic factor. Human and rat CRF (rCRF) also have been purified and synthesized. They have an 83% sequence homology with ovine CRF (oCRF). oCRF-like activity has been found in human hypothalamus, pituitary stalk, posterior pituitary, thalamus, cerebral cortex, cerebellum, pons, medulla oblongata, spinal cord and in the adrenal, lung, liver, stomach, duodenum and pancreas. oCRF-like activity also has been found in the human placenta and in tissues producing ectopic ACTH. The action of CRF can be potentiated by vasopressin, oxytocin, epinephrine, norepinephrine, VIP, and angiotensin II. Intracerebroventricular administration of CRF in the rat produces prolonged elevations of plasma epinephrine, norepinephrine, glucose and glucagon; elevates mean arterial pressure and heart rate; increases motor activity and exploration in familiar surroundings and oxygen consumption; and decreases feeding and sexual behavior. Testing with CRF has enabled the separation of patients with hypothalamic and pituitary adrenal insufficiency. The CRF stimulation test has been useful in distinguishing pituitary from ectopic causes of Cushing's disease. The distribution of CRF within and beyond the hypothalamus provides an anatomical context for the observation that CRF can simultaneously activate and coordinate metabolic, circulatory and behavioral responses that are adaptative in 'stressful' situations. CRF not only stimulates the pituitary-adrenal axis in man, but it also influences several aspects of CNS function which may be of relevance to psychiatric illnesses.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Emeric-Sauval Edoi
10.1016/0306-4530(86)90014-4subject
Has Abstractpub_date
1986-01-01 00:00:00pages
277-94issue
3eissn
0306-4530issn
1873-3360journal_volume
11pub_type
杂志文章,评审abstract：:Nesfatin-1 has been discovered a decade ago and since then drawn a lot of attention. The initially proposed anorexigenic effect was followed by the description of several other involvements such as a role in gastrointestinal motility, glucose homeostasis, cardiovascular functions and thermoregulation giving rise to a ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2018.09.037
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.02.010
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,meta分析,评审
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pub_type： 杂志文章,随机对照试验
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更新日期：2009-07-01 00:00:00
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(84)90020-9
更新日期：1984-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(90)90060-m
更新日期：1990-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,meta分析
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更新日期：2017-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2009.08.003
更新日期：2010-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(99)00015-3
更新日期：1999-08-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：2003-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2014-07-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：2010-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-09-01 00:00:00
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pub_type： 杂志文章
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