Abstract：
:Previous research has found an association between a smaller cerebellar volume and higher levels of neuroticism. The steroid hormone testosterone reduces stress responses and the susceptibility to negative mood. Together with in vitro studies showing a positive effect of testosterone on cerebellar gray matter volumes, we set out to explore the role of testosterone in the relation between cerebellar gray matter and neuroticism. Structural magnetic resonance imaging scans were acquired, and indices of neurotic personality traits were assessed by administering the depression and anxiety scale of the revised NEO personality inventory and Gray's behavioural avoidance in one hundred and forty-nine healthy volunteers between 12 and 27 years of age. Results demonstrated an inverse relation between total brain corrected cerebellar volumes and neurotic personality traits in adolescents and young adults. In males, higher endogenous testosterone levels were associated with lower scores on neurotic personality traits and larger cerebellar gray matter volumes. No such relations were observed in the female participants. Analyses showed that testosterone significantly mediated the relation between male cerebellar gray matter and measures of neuroticism. Our findings on the interrelations between endogenous testosterone, neuroticism and cerebellar morphology provide a cerebellum-oriented framework for the susceptibility to experience negative emotions and mood in adolescence and early adulthood.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Schutter DJLG,Meuwese R,Bos MGN,Crone EA,Peper JSdoi
10.1016/j.psyneuen.2017.01.009subject
Has Abstractpub_date
2017-04-01 00:00:00pages
203-212eissn
0306-4530issn
1873-3360pii
S0306-4530(16)30688-6journal_volume
78pub_type
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journal_title：Psychoneuroendocrinology
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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