当前位置： SCI文献检索 > PSYCHONEUROENDOCRINOLOGY期刊下所有文献 > Parental separation in childhood and adult inflammation: the importance of material and psychosocial pathways.

Parental separation in childhood and adult inflammation: the importance of material and psychosocial pathways.

Abstract：

BACKGROUND:Childhood adversities are known to be associated with poorer health outcomes. A potential mechanism may be through changes in inflammatory processes. One such childhood adversity is separation of parents, however relatively little is known about the association between parental separation and inflammation in adulthood. The aims of this study were to (1) investigate whether parental separation is associated with inflammation in mid-life, (2) focus upon the mechanisms that may be involved in translating childhood adversities, such as parental separation, into poorer health outcomes in adulthood. METHODS:We examine the association of parental separation in childhood, defined as the breakdown of the parent's partnership, and levels of C-reactive protein (CRP) in middle age. The role played by material (through material disadvantage and educational attainment), psychosocial (through parent-child relationship quality and psychological distress) and adiposity (through BMI) mechanisms is investigated using path analysis in a multiply-imputed dataset from a British birth cohort with concurrent measurements made throughout the life course (n=7462). RESULTS:Participants that report parental separation have higher CRP levels at age 44 than those who grew up with both parents (β=0.16, 95% CI: 0.06, 0.27). This association is largely explained by BMI, material and psychosocial factors. Material disadvantage after separation and educational attainment seem to be particularly important in this association. CONCLUSIONS:Parental separation increases CRP in adulthood via chains of disadvantage across the life course. This study points towards potential points for intervention and highlights a need to support separating families in order to minimise the long-term impact on adult health.

journal_name

Psychoneuroendocrinology

journal_title

Psychoneuroendocrinology

authors

Lacey RE,Kumari M,McMunn A

doi

10.1016/j.psyneuen.2013.05.007

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

2476-84

issue

11

eissn

0306-4530

issn

1873-3360

pii

S0306-4530(13)00184-4

journal_volume

38

pub_type

杂志文章

相关文献

PSYCHONEUROENDOCRINOLOGY文献大全
  • Use of an estradiol-based combined oral contraceptives has no influence on attentional bias or depressive symptoms in healthy women.

    abstract：:Combined oral contraceptive (COC) use is associated with small, albeit significant, increases in mental symptom scores, predominantly irritability, depressed mood, and anxiety. Yet, randomized prospective trials are needed to better characterize the women at risk for COC-induced negative mood change. Thus, the primary...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.psyneuen.2019.104544

    authors： Scheuringer A,Lundin C,Derntl B,Pletzer B,Sundström Poromaa I

    更新日期：2020-03-01 00:00:00

  • Cesarean delivery and infant cortisol regulation.

    abstract：BACKGROUND:Cesarean delivery reduces the risk of infant and maternal morbidity and mortality when medically indicated, however, the cesarean delivery rate is estimated to be two to three times higher than medically necessary. The World Health Organization and American College of Obstetricians and Gynecologists have exp...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.104862

    authors： Martinez LD,Glynn LM,Sandman CA,Wing DA,Davis EP

    更新日期：2020-12-01 00:00:00

  • Perceived control moderates the influence of active coping on salivary cortisol response to acute pain among women but not men.

    abstract：:It is generally established that active-coping strategies and greater perceived control over pain are associated with improved pain-related outcomes; however, it remains unclear whether these factors independently or interactively influence adrenocortical function in reaction to a painful stimulus. The present study e...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2009.12.003

    authors： Bento SP,Goodin BR,Fabian LA,Page GG,Quinn NB,McGuire L

    更新日期：2010-07-01 00:00:00

  • How stress and anxiety can alter immediate and late phase skin test responses in allergic rhinitis.

    abstract：:Allergic rhinitis (AR) is the fifth most common chronic disease, and the association between allergic disorders and anxiety is well-documented. To investigate how anxiety and stressors modulate skin prick test (SPT) responses and associated inflammatory responses, 28 men and women with AR were selected by clinical his...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.psyneuen.2008.11.010

    authors： Kiecolt-Glaser JK,Heffner KL,Glaser R,Malarkey WB,Porter K,Atkinson C,Laskowski B,Lemeshow S,Marshall GD

    更新日期：2009-06-01 00:00:00

  • Dose-dependent growth hormone, prolactin and cortisol stimulation after i.v. administration of desimipramine in human subjects.

    abstract：:In previous studies it was shown that the tricyclic antidepressant desimipramine (DMI) had different stimulatory effects on growth hormone (GH), prolactin (PRL), ACTH and cortisol secretion in healthy subjects, depending on the mode of administration. The present study examined the effects following i.v. administratio...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0306-4530(85)90042-3

    authors： Laakmann G,Schoen HW,Blaschke D,Wittmann M

    更新日期：1985-01-01 00:00:00

  • Physical activity and cortisol in anorexia nervosa.

    abstract：:Elevated physical activity is commonly observed among patients with Anorexia Nervosa (AN) and can manifest in several forms. While elevated physical activity may play a key role in the pathophysiology of this disorder, much remains unknown about it, including the relationship among its various manifestations, and thei...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2007.03.007

    authors： Klein DA,Mayer LE,Schebendach JE,Walsh BT

    更新日期：2007-06-01 00:00:00

  • Estradiol potentiates inhibitory synaptic transmission in the oval bed nucleus of the striaterminalis of male and female rats.

    abstract：:17ß-Estradiol (E2) is a potent neuromodulator capable of producing changes in inhibitory synaptic transmission by either changing pre-synaptic GABA release or post-synaptic GABAA receptor function. Physiologically, E2 is important for energy homeostasis, influencing food consumption, body weight, adipose tissue metabo...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2019.03.030

    authors： Gregory JG,Hawken ER,Angelis S,Bouchard JF,Dumont ÉC

    更新日期：2019-08-01 00:00:00

  • Stress and immune biomarkers interact with parenting behavior to shape anxiety symptoms in trauma-exposed youth.

    abstract：:The relations between stress, HPA-axis, and the immune system have been extensively studied; however, no study to date addressed the joint contribution of immune and HPA biomarkers to the development of anxiety in youth exposed to chronic trauma as mediated by mother-child interaction patterns. A unique cohort of war-...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2018.08.016

    authors： Yirmiya K,Djalovski A,Motsan S,Zagoory-Sharon O,Feldman R

    更新日期：2018-12-01 00:00:00

  • Differences in the response to the combined DEX-CRH test between PTSD patients with and without co-morbid depressive disorder.

    abstract：BACKGROUND:Neuroendocrine studies have shown profound alterations in HPA-axis regulation in posttraumatic stress disorder (PTSD). Based on baseline assessments and the response to dexamethasone, a hypothalamic overdrive with enhanced glucocorticoid feedback inhibition has been suggested. The dexamethasone-corticotrophi...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2007.11.016

    authors： de Kloet C,Vermetten E,Lentjes E,Geuze E,van Pelt J,Manuel R,Heijnen C,Westenberg H

    更新日期：2008-04-01 00:00:00

  • Pituitary-gonadal function during sleep in healthy aging men.

    abstract：:There is limited information on the relation between age-related changes in pituitary-gonadal function and sleep physiology in older men. In this cross-sectional study of 67 healthy volunteers free from sleep complaints, aged 45-75 yr, we (1) assessed peak fluctuations and hourly variations in plasma testosterone, LH ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/0306-4530(92)90018-3

    authors： Schiavi RC,White D,Mandeli J

    更新日期：1992-11-01 00:00:00

  • Day length predicts investment in human immune function: Shorter days yield greater investment.

    abstract：:Winter is characterized by stressful conditions which compromise health and render animals more vulnerable to infection and illness than during other times of the year. Organisms are hypothesized to adapt to these seasonal stressors by increasing investment in immune function in response to diminished photoperiod dura...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2019.05.011

    authors： Gassen J,Proffitt Leyva RP,Mengelkoch S,White JD,Peterman JL,Prokosch ML,Bradshaw HK,Eimerbrink MJ,Corrigan EK,Cheek DJ,Boehm GW,Hill SE

    更新日期：2019-09-01 00:00:00

  • Post-exposure cortisol administration does not augment the success of exposure therapy: A randomized placebo-controlled study.

    abstract：:Cortisol administration prior to treatment can promote the efficacy of exposure-based treatments in specific phobia: cortisol has been proposed to reduce fear retrieval at the beginning of exposure and to enhance the acquisition and consolidation of corrective information learned during exposure. Whether cortisol exer...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.psyneuen.2018.09.015

    authors： Raeder F,Merz CJ,Tegenthoff M,Wolf OT,Margraf J,Zlomuzica A

    更新日期：2019-01-01 00:00:00

  • Gender differences in schizophrenia.

    abstract：:Sex differences in schizophrenia can be caused by the disease process itself, by genetic and hormonal differences, by differences in the maturation and morphology of the brain and in age- and gender-specific behavioural patterns. These hypotheses will be tested on the major results reported in the literature as well a...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/s0306-4530(02)00125-7

    authors： Häfner H

    更新日期：2003-04-01 00:00:00

  • Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy.

    abstract：:The relationship between immune activation and the development of early depressive symptoms were studied in 33 cancer patients undergoing cytokine therapy. Patients were treated either with subcutaneous IL-2 administered alone (n=13) or in association with IFN-alpha (n=5), or with IFN-alpha alone administered subcutan...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0306-4530(01)00030-0

    authors： Capuron L,Ravaud A,Gualde N,Bosmans E,Dantzer R,Maes M,Neveu PJ

    更新日期：2001-11-01 00:00:00

  • The role of inflammation in the association between poverty and working memory in childhood.

    abstract：BACKGROUND:Family financial difficulties have been directly linked to poorer executive functioning in childhood. However, recent studies suggest that difficulties in affording basic items and other necessities may also indirectly affect children's executive functions through several psychological but also physiological...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.105040

    authors： Kokosi T,Flouri E,Midouhas E

    更新日期：2021-01-01 00:00:00

  • Ghrelin in psychiatric disorders - A review.

    abstract：:Ghrelin is a 28-amino-acid peptide hormone, first described in 1999 and broadly expressed in the organism. As the only known orexigenic hormone secreted in the periphery, it increases hunger and appetite, promoting food intake. Ghrelin has also been shown to be involved in various physiological processes being regulat...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.psyneuen.2014.11.013

    authors： Wittekind DA,Kluge M

    更新日期：2015-02-01 00:00:00

  • A new view on hypocortisolism.

    abstract：:Low cortisol levels have been observed in patients with different stress-related disorders such as chronic fatigue syndrome, fibromyalgia, and post-traumatic stress disorder. Data suggest that these disorders are characterized by a symptom triad of enhanced stress sensitivity, pain, and fatigue. This overview will pre...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.psyneuen.2005.04.006

    authors： Fries E,Hesse J,Hellhammer J,Hellhammer DH

    更新日期：2005-11-01 00:00:00

  • Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats.

    abstract：:Beside its hormonal function in salt and water homeostasis, vasopressin released into distinct brain areas plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state. We aimed to investigate whether correction of the peripheral symptoms of congenital absence of AVP...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2014.09.011

    authors： Balázsfi D,Pintér O,Klausz B,Kovács KB,Fodor A,Török B,Engelmann M,Zelena D

    更新日期：2015-01-01 00:00:00

  • Mouse females devoid of exposure to males during fetal development exhibit increased maternal behavior.

    abstract：:Many sex differences can be found in the expression of aggression and parental nurturing behaviors. It is important to determine if these are modulated by prenatal conditions. Here, using assisted reproduction technologies, we generated females that were (mixed-sex) or were not (same-sex) exposed to males during fetal...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2011.07.009

    authors： Sugawara A,Pearson BL,Blanchard DC,Ward MA

    更新日期：2012-03-01 00:00:00

  • Environmental enrichment models a naturalistic form of maternal separation and shapes the anxiety response patterns of offspring.

    abstract：:Environmental enrichment (EE) mimics positive life experiences by providing enhanced social and physical stimulation. Placement into EE following weaning, or in later life, confers beneficial outcomes on both emotional and cognitive processes. However, anxiety-like behavior is also reported, particularly in rats expos...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2014.10.021

    authors： Connors EJ,Migliore MM,Pillsbury SL,Shaik AN,Kentner AC

    更新日期：2015-02-01 00:00:00

  • Absence of a normal cortisol awakening response (CAR) in adolescent males with Asperger syndrome (AS).

    abstract：:In addition to abnormalities in social and communication development, a 'need for sameness' and 'resistance to change' are features of autistic spectrum disorders first identified by Kanner in 1943. Our ability to react to change is modulated by the hypothalamic-pituitary-adrenal (HPA) axis, a feature of which is a dr...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2009.02.011

    authors： Brosnan M,Turner-Cobb J,Munro-Naan Z,Jessop D

    更新日期：2009-08-01 00:00:00

  • Cortisol modulates men's affiliative responses to acute social stress.

    abstract：:The dominant characterization of the physiological and behavioral human stress reaction is the fight-or-flight response. On the other hand, it has been suggested that social affiliation during stressful times ("tend-and-befriend") also represents a common adaptive response to stress, particularly for women. In the cur...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2015.09.004

    authors： Berger J,Heinrichs M,von Dawans B,Way BM,Chen FS

    更新日期：2016-01-01 00:00:00

  • Reboxetine acutely stimulates cortisol, ACTH, growth hormone and prolactin secretion in healthy male subjects.

    abstract：:In this single-blind study the effects of acute oral administration of the selective noradrenaline reuptake inhibitor reboxetine on the cortisol (COR), ACTH, growth hormone (GH) and prolactin (PRL) secretion were examined in 12 healthy male volunteers. In a randomized order, the subjects received placebo or reboxetine...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0306-4530(03)00022-2

    authors： Schüle C,Baghai T,Schmidbauer S,Bidlingmaier M,Strasburger CJ,Laakmann G

    更新日期：2004-02-01 00:00:00

  • Stress-related peripheral neuroendocrine-immune interactions in women with ulcerative colitis.

    abstract：OBJECTIVES:The mechanisms underlying the interaction of psychological stress with the disease course in inflammatory bowel diseases remain unclear. We analyzed the neuroendocrine and cellular immune responses to public speaking stress, and the in vitro adrenergic and glucocorticoid modulation of cytokine production by ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2007.09.003

    authors： Langhorst J,Cobelens PM,Kavelaars A,Heijnen CJ,Benson S,Rifaie N,Dobos GJ,Schedlowski M,Elsenbruch S

    更新日期：2007-09-01 00:00:00

  • Maltreatment and diurnal cortisol regulation: A meta-analysis.

    abstract：:Childhood maltreatment leads to a host of negative physical and mental health outcomes, with cortisol dysregulation implicated as a possible mechanism. Given inconsistencies across in the literature regarding the direction and magnitude of the association between maltreatment and diurnal cortisol regulation, the curre...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.psyneuen.2017.01.005

    authors： Bernard K,Frost A,Bennett CB,Lindhiem O

    更新日期：2017-04-01 00:00:00

  • The social curse: Evidence for a moderating effect of shared social identity on contagious stress reactions.

    abstract：:Contagious stress describes the transmission of a stress response from a distressed individual (target) to an uninvolved observer. Building on social identity theory, we hypothesize that a shared social identity between the observer and the target as compared to a personal identity increases the likelihood of contagio...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.104896

    authors： Schury VA,Nater UM,Häusser JA

    更新日期：2020-12-01 00:00:00

  • Nucleus accumbens mu opioid receptors regulate context-specific social preferences in the juvenile rat.

    abstract：:The μ opioid receptor (MOR) in the nucleus accumbens (NAc) is involved in assigning pleasurable, or hedonic value to rewarding stimuli. Importantly, the hedonic value of a given rewarding stimulus likely depends on an individual's current motivational state. Here, we examined the involvement of MORs in the motivation ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2017.12.017

    authors： Smith CJW,Wilkins KB,Li S,Tulimieri MT,Veenema AH

    更新日期：2018-03-01 00:00:00

  • No major month to month variation in free testosterone levels in aging males. Minor impact on the biological diagnosis of 'andropause'.

    abstract：BACKGROUND:The measurement of bioavailable testosterone (BT) or free testosterone (FT) levels is currently considered the gold standard for the diagnosis of androgen deficiency in elderly men. While the impact of age on circulating testosterone levels (total, bioavailable and free) has been strongly documented, the exi...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2005.02.002

    authors： Tancredi A,Reginster JY,Luyckx F,Legros JJ

    更新日期：2005-08-01 00:00:00

  • The beneficial effects of strength exercise on hippocampal cell proliferation and apoptotic signaling is impaired by anabolic androgenic steroids.

    abstract：:Previous studies have shown that strength exercise improves memory and increases expression of a myriad of proteins involved on neuronal survival and synaptic plasticity in the hippocampus. Conversely, chronic exposure to supraphysiological levels of anabolic androgenic steroids (AAS) can induce psychiatric abnormalit...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2014.08.009

    authors： Novaes Gomes FG,Fernandes J,Vannucci Campos D,Cassilhas RC,Viana GM,D'Almeida V,de Moraes Rêgo MK,Buainain PI,Cavalheiro EA,Arida RM

    更新日期：2014-12-01 00:00:00

  • Maternal cortisol output in pregnancy and newborn telomere length: Evidence for sex-specific effects.

    abstract：:Newborn telomere length is a potential biomarker of the effects of maternal-fetal processes on offspring long-term health. A number of maternal psychosocial and environmental factors in pregnancy (e.g., stress, health, socioeconomic status) have been associated with shortened telomere length at birth. The physiologica...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2018.12.222

    authors： Bosquet Enlow M,Sideridis G,Bollati V,Hoxha M,Hacker MR,Wright RJ

    更新日期：2019-04-01 00:00:00