当前位置： SCI文献检索 > PSYCHONEUROENDOCRINOLOGY期刊下所有文献 > Estradiol potentiates inhibitory synaptic transmission in the oval bed nucleus of the striaterminalis of male and female rats.

Estradiol potentiates inhibitory synaptic transmission in the oval bed nucleus of the striaterminalis of male and female rats.

Abstract：

:17ß-Estradiol (E2) is a potent neuromodulator capable of producing changes in inhibitory synaptic transmission by either changing pre-synaptic GABA release or post-synaptic GABAA receptor function. Physiologically, E2 is important for energy homeostasis, influencing food consumption, body weight, adipose tissue metabolism and energy expenditure. E2 may influence energy homeostasis through estrogen receptor-rich regions such as the oval bed nucleus of the stria-terminalis (ovBNST). However, the neurophysiological effects of estradiol within the ovBNST remain largely unknown. Understanding how E2 affects inhibitory transmission may elucidate the ovBNST's contribution to energy homeostasis. Here, using brain slice electrophysiology, we saw that E2 produced a long-term potentiation (LTP) of GABAA synaptic transmission (LTPGABA) in the ovBNST in male rats. E2 acted on estrogen receptors α and G-protein coupled estrogen receptors (GPER), involved protein kinase activation and required an intact endocannabinoid system. The effects of E2 in males were sensitive to 24 h of food deprivation. In females, E2 was 100-fold more potent at producing LTPGABA ovBNST compared to male rats and involved all three known subtypes of estrogen receptors (ERα, ERß, and GPER). These results demonstrate that E2 is a potent neuromodulator of inhibitory synaptic transmission within the ovBNST of both sexes to potentially regulate energy homeostasis.

journal_name

Psychoneuroendocrinology

journal_title

Psychoneuroendocrinology

authors

Gregory JG,Hawken ER,Angelis S,Bouchard JF,Dumont ÉC

doi

10.1016/j.psyneuen.2019.03.030

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

102-110

eissn

0306-4530

issn

1873-3360

pii

S0306-4530(18)31008-4

journal_volume

106

pub_type

杂志文章

相关文献

PSYCHONEUROENDOCRINOLOGY文献大全
  • Swim stress differentially blocks CRF receptor mediated responses in dorsal raphe nucleus.

    abstract：:Modulation of the serotonergic (5-HT) neurotransmitter system arising from the dorsal raphe nucleus (DR) is thought to support the behavioral effects of swim stress, i.e., immobility. In vivo pharmacological and anatomical studies suggest that corticotropin-releasing factor (CRF) and γ-aminobutyric acid (GABA) synapti...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2010.03.003

    authors： Lamy CM,Beck SG

    更新日期：2010-10-01 00:00:00

  • Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction.

    abstract：BACKGROUND:Recent data suggest that ghrelin is involved in the pathophysiology of alcohol use disorders, affecting alcohol self-administration and craving. Gastric ghrelin secretion is reduced by stomach distension. We now tested the hypothesis whether the clinically well-known effects of high-volume water intake on cr...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.psyneuen.2017.08.005

    authors： Koopmann A,Lippmann K,Schuster R,Reinhard I,Bach P,Weil G,Rietschel M,Witt SH,Wiedemann K,Kiefer F

    更新日期：2017-11-01 00:00:00

  • Processing of food stimuli is selectively enhanced during insulin-induced hypoglycemia in healthy men.

    abstract：:Recently it has been reported that during insulin-induced hypoglycemia selective attention is directed to food stimuli suggesting an adaptive cognitive strategy to escape from this potentially dangerous metabolic state. Here, we tested this hypothesis using a short-term memory task. We also aimed to define a hypoglyce...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.psyneuen.2004.12.006

    authors： Schultes B,Peters A,Kern W,Gais S,Oltmanns KM,Fehm HL,Born J

    更新日期：2005-06-01 00:00:00

  • Role of nesfatin-1 in anxiety, depression and the response to stress.

    abstract：:Nesfatin-1 has been discovered a decade ago and since then drawn a lot of attention. The initially proposed anorexigenic effect was followed by the description of several other involvements such as a role in gastrointestinal motility, glucose homeostasis, cardiovascular functions and thermoregulation giving rise to a ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.psyneuen.2018.09.037

    authors： Weibert E,Hofmann T,Stengel A

    更新日期：2019-02-01 00:00:00

  • Hippocampal insulin resistance links maternal obesity with impaired neuronal plasticity in adult offspring.

    abstract：OBJECTIVE:Maternal obesity and a disturbed metabolic environment during pregnancy and lactation have been shown to result in many long-term health consequences for the offspring. Among them, impairments in neurocognitive development and performance belong to the most dreaded ones. So far, very few mechanistic approache...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2017.12.023

    authors： Schmitz L,Kuglin R,Bae-Gartz I,Janoschek R,Appel S,Mesaros A,Jakovcevski I,Vohlen C,Handwerk M,Ensenauer R,Dötsch J,Hucklenbruch-Rother E

    更新日期：2018-03-01 00:00:00

  • Experienced discrimination and racial differences in leukocyte gene expression.

    abstract：:Racial disparities in health outcomes between African Americans and European Americans have been well-documented, but not fully understood. Chronic inflammation contributes to several of the diseases showing racial disparities (e.g., Human Immunodeficiency Virus [HIV]), and racial differences in stress exposure (e.g.,...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2019.04.016

    authors： Thames AD,Irwin MR,Breen EC,Cole SW

    更新日期：2019-08-01 00:00:00

  • Neural basis of maternal behavior in the rat.

    abstract：:This article presents a review of the neural and neurochemical regulation of maternal behavior in the rat, emphasizing the role of the medial preoptic area (MPOA) and its neural connections in this regulation. Evidence for the role of the MPOA includes the following and will be discussed: (1) Axon-sparing lesions of t...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/0306-4530(88)90006-6

    authors： Numan M

    更新日期：1988-01-01 00:00:00

  • Hair cortisol as a biomarker of stress and resilience in South African mixed ancestry females.

    abstract：BACKGROUND:Hair cortisol concentrations (HCC) are increasingly used as a biomarker of stress, however limited research exists regarding the relationship between HCC and protective factors, such as resilience. Additionally, studies measuring HCC need to account for possible confounders, and these factors have not been e...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2019.104543

    authors： van den Heuvel LL,Acker D,du Plessis S,Stalder T,Suliman S,Thorne MY,Kirschbaum C,Seedat S

    更新日期：2020-03-01 00:00:00

  • Psychological determinants of the cortisol stress response: the role of anticipatory cognitive appraisal.

    abstract：:Psychosocial stress is a potent activator of the hypothalamus-pituitary-adrenal (HPA) axis. While the physiological mechanisms of HPA axis responses to stress as well as its short and long-term consequences have been extensively examined, less is known why someone elicits an acute neuroendocrine stress response, i.e. ...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.psyneuen.2005.02.001

    authors： Gaab J,Rohleder N,Nater UM,Ehlert U

    更新日期：2005-07-01 00:00:00

  • Estradiol and raloxifene modulate hippocampal gamma oscillations during a spatial memory task.

    abstract：:Previous work suggests that estradiol regulates the expression of hippocampal parvalbumin as well as hippocampus-dependent spatial memory in mice. Parvalbumin interneurons generate neuronal oscillatory activity in the gamma frequency range (30-80Hz) and gamma oscillations are closely linked with higher cognitive funct...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2017.01.022

    authors： Schroeder A,Hudson M,Du X,Wu YWC,Nakamura J,van den Buuse M,Jones NC,Hill RA

    更新日期：2017-04-01 00:00:00

  • The brain as a target for adrenocortical steroids: cognitive implications.

    abstract：:It is well established that a reciprocal control exists between the brain and glucocorticoid hormones. The brain regulates adrenocortical function via hypothalamic corticotrophin releasing hormone-41 (CRH-41), glucocorticoids act at specific receptors in the hippocampus, thus promoting negative feedback mechanisms. Be...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/0306-4530(92)90040-e

    authors： Martignoni E,Costa A,Sinforiani E,Liuzzi A,Chiodini P,Mauri M,Bono G,Nappi G

    更新日期：1992-08-01 00:00:00

  • Perceived stress, depressive symptoms, and cortisol-to-cortisone ratio in spot urine in 6878 older adults.

    abstract：BACKGROUND:Late life depression and perceived stress could influence disease pathways via reduced 11β-HSD2 activity, particularly given suggestions that reduced 11β-HSD2 activity, which is reflected in the cortisol-to-cortisone ratio, is a risk factor of disease. To date, however, examination of the relationship betwee...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.105125

    authors： Shimanoe C,Matsumoto A,Hara M,Akao C,Nishida Y,Horita M,Nanri H,Higaki Y,Tanaka K

    更新日期：2020-12-30 00:00:00

  • Expression of tumor necrosis factor-alpha and interferon-gamma mRNA in blood cells correlates with depression scores during an acute attack in patients with multiple sclerosis.

    abstract：:Depression is a common problem in multiple sclerosis (MS) and affects about 50% of MS patients. Since a dysregulation of cytokine levels has been implicated in the pathogenesis of MS and alterations in cytokine serum levels have been found in depressive illness, we examined the relationship between depressive symptoms...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/s0306-4530(01)00068-3

    authors： Kahl KG,Kruse N,Faller H,Weiss H,Rieckmann P

    更新日期：2002-08-01 00:00:00

  • Pain exposure associates with telomere length erosion in very preterm infants.

    abstract：:Very preterm (VPT) infants (gestational age < 32 weeks) require long-lasting hospitalization in the Neonatal Intensive Care Unit (NICU), even in absence of severe morbidities. During NICU stay, life-saving interventions occur and include invasive and painful skin-breaking procedures (NICU-related stress), which consti...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2018.01.009

    authors： Provenzi L,Giorda R,Fumagalli M,Pozzoli U,Morandi F,Scotto di Minico G,Mosca F,Borgatti R,Montirosso R

    更新日期：2018-03-01 00:00:00

  • Influence of marital status on testosterone levels-A ten year follow-up of 1113 men.

    abstract：:Based on a large population of 1113 men aged 30-60 at baseline (mean: 44.1 years, standard deviation: 10.5), we investigated whether intra-individual changes in testosterone (T) and related reproductive hormones during a ten year period were dependent of marital status at baseline and follow-up. The studied men were p...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2017.03.010

    authors： Holmboe SA,Priskorn L,Jørgensen N,Skakkebaek NE,Linneberg A,Juul A,Andersson AM

    更新日期：2017-06-01 00:00:00

  • The effects of post-awakening light exposure on the cortisol awakening response in healthy male individuals.

    abstract：BACKGROUND:It is assumed that the expression of the cortisol awakening response (CAR) is modulated by light exposure during the peri-awakening period. While initial evidence supports this principal effect, the specific role of the spectral composition of light (brightness and wavelength) is still incompletely understoo...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2019.05.016

    authors： Petrowski K,Schmalbach B,Niedling M,Stalder T

    更新日期：2019-10-01 00:00:00

  • Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders.

    abstract：:The science of neuroimmunopsychiatry has evolved rapidly in the last few years with the hope of tackling the unmet need in mood disorders. This article focuses on an inflammatory pathway, highly conserved in myeloid cells that may play a role in neuroinflammatory disorders including depression. Within the brain tissue...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.psyneuen.2018.08.015

    authors： Bhattacharya A,Jones DNC

    更新日期：2018-12-01 00:00:00

  • Use of an estradiol-based combined oral contraceptives has no influence on attentional bias or depressive symptoms in healthy women.

    abstract：:Combined oral contraceptive (COC) use is associated with small, albeit significant, increases in mental symptom scores, predominantly irritability, depressed mood, and anxiety. Yet, randomized prospective trials are needed to better characterize the women at risk for COC-induced negative mood change. Thus, the primary...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.psyneuen.2019.104544

    authors： Scheuringer A,Lundin C,Derntl B,Pletzer B,Sundström Poromaa I

    更新日期：2020-03-01 00:00:00

  • High cortisol awakening response in the aftermath of workplace violence exposure moderates the association between acute stress disorder symptoms and PTSD symptoms.

    abstract：:Although a majority of people will be exposed to a traumatic event over the course of their lifespan, only a minority will develop post-traumatic stress disorder. Better understanding the factors contributing to the development of this psychopathology is of high importance and could significantly reduce the societal a...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2019.03.006

    authors： Marin MF,Geoffrion S,Juster RP,Giguère CE,Marchand A,Lupien SJ,Guay S

    更新日期：2019-06-01 00:00:00

  • PTSD symptoms and cortisol stress reactivity in adolescence: Findings from a high adversity cohort in South Africa.

    abstract：BACKGROUND:Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is implicated in the pathophysiology of post-traumatic stress disorder (PTSD). However, there has been little study of HPA stress reactivity in association with PTSD symptoms (PTSS) in children; and there is limited research on PTSD in low and mi...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.104846

    authors： Zimmerman A,Halligan S,Skeen S,Morgan B,Fraser A,Fearon P,Tomlinson M

    更新日期：2020-11-01 00:00:00

  • The impact of perceived intensity and frequency of police work occupational stressors on the cortisol awakening response (CAR): Findings from the BCOPS study.

    abstract：:Police officers encounter unpredictable, evolving, and escalating stressful demands in their work. Utilizing the Spielberger Police Stress Survey (60-item instrument for assessing specific conditions or events considered to be stressors in police work), the present study examined the association of the top five highly...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2016.10.017

    authors： Violanti JM,Fekedulegn D,Andrew ME,Hartley TA,Charles LE,Miller DB,Burchfiel CM

    更新日期：2017-01-01 00:00:00

  • Immobilization-induced stress decreases lipogenesis in sebaceous glands as well as plasma testosterone levels in male Syrian hamsters.

    abstract：:The effects of immobilization-induced stress on plasma testosterone levels and lipogenesis in the sebaceous gland were examined in male Syrian hamsters. To induce immobilization stress, the animals were placed in the prone position and wrapped with flexible steel wire gauze at room temperature. Plasma testosterone lev...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/0306-4530(94)00055-f

    authors： Tsuchiya T,Horii I

    更新日期：1995-01-01 00:00:00

  • Differential responses in prolactin levels induced by naloxone in humans.

    abstract：:The plasma prolactin (PRL) response to the opiate antagonist naloxone was tested in drug-free healthy volunteers (10 men, 18 regularly menstruating women who were in the late follicular phase of their ovarian cycles, and seven post-menopausal women). Naloxone hydrochloride (2 mg intravenous bolus) and placebo (normal ...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0306-4530(85)90058-7

    authors： Steardo L,Monteleone P,Tamminga CA,Canonico PL,Denman D,Scapagnini U,Chase TN

    更新日期：1985-01-01 00:00:00

  • Microglial-driven changes in synaptic plasticity: A possible role in major depressive disorder.

    abstract：:Recent data gathered from both in vitro and in vivo models of Major Depressive Disorder (MDD) have indicated that microglia play an active role in modifying some of the most important sources for neuronal plasticity, specifically long-term potentiation (LTP) and long-term depression (LTD). In addition, microglia have ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.psyneuen.2018.12.233

    authors： Innes S,Pariante CM,Borsini A

    更新日期：2019-04-01 00:00:00

  • Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test.

    abstract：:The rat forced swim test (FST) is a model that is used extensively as a screening test for antidepressant activity. It has previously been reported that thorough analysis of behaviour in this model reveals two distinct types of active response - climbing and swimming - and that these are separately evoked by re-uptake...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/s0306-4530(02)00026-4

    authors： Kelliher P,Kelly JP,Leonard BE,Sánchez C

    更新日期：2003-04-01 00:00:00

  • Dual-hormone stress reactivity predicts downstream war-zone stress-evoked PTSD.

    abstract：BACKGROUND:The crucial role of the hypothalamic-pituitary-adrenal axis (HPA) in stress-related homeostasis suggests dysregulated HPA involvement in the pathogenesis of post-traumatic stress disorder (PTSD), yet most studies examining linkages between HPA axis measures and PTSD have yielded null findings. One untested e...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2017.01.013

    authors： Josephs RA,Cobb AR,Lancaster CL,Lee HJ,Telch MJ

    更新日期：2017-04-01 00:00:00

  • Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen.

    abstract：:Frequent or chronic stress as a result of repeated or persistent exposure to social challenges has been shown to affect the glucocorticoid (GC) responsiveness of immune cells in mice. Lipopolysaccharide-stimulated splenocytes of mice that were repeatedly subjected to social disruption were less sensitive to the anti-i...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2007.10.007

    authors： Engler H,Bailey MT,Engler A,Stiner-Jones LM,Quan N,Sheridan JF

    更新日期：2008-01-01 00:00:00

  • Suppression, but not reappraisal, is associated with inflammation in trauma-exposed veterans.

    abstract：BACKGROUND:Emotion dysregulation can elicit inflammatory activity. The current study examined whether specific maladaptive and adaptive emotion regulation strategies were associated with inflammatory markers in trauma-exposed veterans, above and beyond PTSD. METHODS:In a cohort study, 606 participants exposed to a Cri...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.104871

    authors： Khan AJ,O'Donovan A,Neylan TC,Gross JJ,Cohen BE

    更新日期：2020-12-01 00:00:00

  • Comparison of growth hormone stimulation induced by desimipramine, diazepam and metaclazepam in man.

    abstract：:A comparison of the effect on growth hormone (GH) stimulation in men (n = 6) of desimipramine (DMI), a tricyclic antidepressant, and of the benzodiazepine derivatives diazepam and metaclazepam with that of a placebo, showed that only DMI caused a significant (p less than 0.01) GH stimulation. After DMI, all six subjec...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0306-4530(82)90006-3

    authors： Laakmann G,Treusch J,Schmauss M,Schmitt E,Treusch U

    更新日期：1982-01-01 00:00:00

  • Neuroendocrine and cardiovascular reactions to acute psychological stress are attenuated in smokers.

    abstract：:A number of studies have now examined the association between smoking and the magnitude of physiological reactions to acute psychological stress. However, no large-scale study has demonstrated this association incorporating neuroendocrine in addition to cardiovascular reactions to stress. The present study compared ne...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.psyneuen.2014.05.023

    authors： Ginty AT,Jones A,Carroll D,Roseboom TJ,Phillips AC,Painter R,de Rooij SR

    更新日期：2014-10-01 00:00:00