Abstract:
:Previous work suggests that estradiol regulates the expression of hippocampal parvalbumin as well as hippocampus-dependent spatial memory in mice. Parvalbumin interneurons generate neuronal oscillatory activity in the gamma frequency range (30-80Hz) and gamma oscillations are closely linked with higher cognitive functions. Raloxifene, a selective estrogen receptor modulator, shows beneficial effects on human cognitive performance, and has few peripheral side effects unlike estradiol, but the biological mechanisms which underpin these benefits are not clear. This study aimed to investigate whether estradiol and raloxifene modulate hippocampal gamma-band oscillations during spatial memory performance. Prepubescent female mice were ovariectomized (OVX) and implanted with a subcutaneous pellet of either estradiol (E2), raloxifene or placebo. During adulthood, local field potentials were recorded from the dorsal hippocampus while mice were performing the Y-maze hippocampus-dependent spatial memory task. Ovariectomy caused deficits in spatial memory, accompanied by a significant reduction in hippocampal gamma oscillations, specifically during decision making. Estradiol as well as raloxifene rescued both behavioural and electrophysiological deficits. These data have significant implications for disorders of cognitive impairment where altered gamma oscillations are apparent, such as schizophrenia.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Schroeder A,Hudson M,Du X,Wu YWC,Nakamura J,van den Buuse M,Jones NC,Hill RAdoi
10.1016/j.psyneuen.2017.01.022subject
Has Abstractpub_date
2017-04-01 00:00:00pages
85-92eissn
0306-4530issn
1873-3360pii
S0306-4530(16)30987-8journal_volume
78pub_type
杂志文章abstract::It is widely assumed that learning and memory processes play an important role in the pathogenesis, expression, maintenance and therapy of anxiety disorders, such as phobias or post-traumatic stress disorder (PTSD). Memory retrieval is involved in symptom expression and maintenance of these disorders, while memory ext...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2009.12.005
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pub_type: 临床试验,杂志文章
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2018-09-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.03.018
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2008.12.005
更新日期:2009-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2006.03.007
更新日期:2006-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.12.222
更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/j.psyneuen.2013.12.009
更新日期:2014-03-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2015.08.011
更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
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