Abstract:
BACKGROUND:Alterations of hypothalamic-pituitary-adrenal (HPA) axis function and sympathetic-adrenal activity have been proposed as key factors in biological models of posttraumatic stress disorder (PTSD). METHODS:We examined neuroendocrine function in female survivors of intimate partner violence (IPV) with lifetime (current or remitted) PTSD (n=29) and in women who were exposed to IPV but never developed PTSD (n=20). Salivary cortisol was collected as a marker of HPA axis function at 1, 4, 9, and 11 h after awakening. Platelet epinephrine and norepinephrine were assayed as markers of sympathetic-adrenal activation. RESULTS:Women with lifetime PTSD had significantly higher cortisol levels across the day compared to abuse-exposed participants without PTSD, after controlling for age, depression, severity, and latency of abuse. There were no significant group differences in levels of platelet catecholamines. CONCLUSIONS:Elevated cortisol levels may be a biomarker of IPV-related lifetime PTSD, reflecting long-lasting changes associated with trauma-exposure or possibly a reflection of risk for PTSD in women.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Inslicht SS,Marmar CR,Neylan TC,Metzler TJ,Hart SL,Otte C,McCaslin SE,Larkin GL,Hyman KB,Baum Adoi
10.1016/j.psyneuen.2006.03.007subject
Has Abstractpub_date
2006-08-01 00:00:00pages
825-38issue
7eissn
0306-4530issn
1873-3360pii
S0306-4530(06)00070-9journal_volume
31pub_type
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