Abstract：
:In the laboratory, prenatal stress produces alterations in the structure and function of corticolimbic neurons. Here we report changes in gene expression and corticolimbic dendritic spine morphology in the offspring of pregnant ewes subjected to aversive interactions with human handlers during the last five weeks of pregnancy (AVS) compared to control dams that received gentle handling (GEN). AVS lambs had higher spine density on pyramidal neurons in area CA1 of the hippocampus and in medial prefrontal cortex compared to GEN lambs, as well as a lower ratio of mushroom spines to stubby and thin spines in area CA1. Expression of genes involved in brain development and spine morphogenesis was decreased in hippocampus and prefrontal cortex in AVS compared to GEN lambs. This study is the first demonstration that an ecologically relevant aversive experience in a field setting alters neuronal structure similarly to previous reports from laboratory settings and that even for animals domesticated over 12,000 years ago, an apparently mild stressor, resulting from human-animal interactions, can have similarly profound impacts on corticolimbic morphology.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Coulon M,Wellman CL,Marjara IS,Janczak AM,Zanella AJdoi
10.1016/j.psyneuen.2012.10.018subject
Has Abstractpub_date
2013-07-01 00:00:00pages
1112-21issue
7eissn
0306-4530issn
1873-3360pii
S0306-4530(12)00353-8journal_volume
38pub_type
杂志文章abstract：:Distinct patterns of cortisol secretion have been associated with depression in past research, but it remains unclear whether individuals at-risk for depression may also have similar patterns of cortisol secretion. This is the first study to date of both naturalistic diurnal cortisol secretion and cortisol reactivity ...
journal_title：Psychoneuroendocrinology
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