Abstract：
:In the female rat, stimulation of the uterine cervix (CS) during mating or by artificial means induces daily diurnal and nocturnal surges in prolactin (PRL) secretion which, in the absence of fertilization, result in an 12-day anestrous period called pseudopregnancy (PSP). The amount or type of mating stimulation received by the female during mating determines whether or not PSP occurs, but it has not yet been determined whether different amounts of mating stimulation can alter the time of onset of PRL surges. The present studies examined the latency in days to the first nocturnal PRL surge following mating. Plasma PRL was measured in samples obtained via intra-atrial catheters at 0200-0500h on the day of estrus (Day 0) and on the subsequent 3 days (Days 1-3). In Experiment 1, proestrus females received mating stimulation which was more than (15 intromissions, 15I) or less than (mounts-without-intromission only, MO) sufficient to induce PSP. Surges were absent in 15I females until Days 1-2 and in MO females on all days. In Experiment 2, females received five intromissions (5I) in paced and nonpaced mating tests, types of mating treatments which were expected to induce PSP in some but not all females. PRL surges were not evident at any sampling time in females that continued to cycle, while PRL surges occurred consistently on Day 2 among PSP females. Among PSP females, those receiving 5I showed significantly higher PRL on Day 0 than did 15I females. In both experiments, plasma progesterone concentrations were not higher in PSP than in non-PSP animals until Day 3. In Experiment 3, PRL levels in single samples obtained by cardiac puncture on Day 0 were similar to those seen in the first two experiments. Thus, PRL secretion at the time of the first postmating nocturnal surge is influenced by the type of CS received some 8-10 h earlier. However, if sufficient CS is received to induce the neural changes of PSP, the nocturnal PRL surges are expressed in an all-or-none fashion by 1-2 days after mating.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Kornberg E,Erskine MSdoi
10.1016/0306-4530(94)90016-7subject
Has Abstractpub_date
1994-01-01 00:00:00pages
357-71issue
4eissn
0306-4530issn
1873-3360pii
0306-4530(94)90016-7journal_volume
19pub_type
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