Abstract：
:Intravenous injection of the cholecystokinin (CCK)-B receptor agonist, pentagastrin, produces robust, dose-dependent release of adrenocorticotropin (ACTH) and cortisol, supporting the hypothesis that CCK-B agonists pharmacologically activate the hypothalamic-pituitary-adrenal (HPA) axis. The mechanism of activation and its physiological relevance remain uncertain. Preliminary data suggest that the ACTH response to pentagastrin may be differentiated from the response to exogenous corticotropin releasing hormone (CRH) by its relative resistance to cortisol feedback inhibition. To more directly test the relationship between cortisol levels and ACTH response to pentagastrin, this study examined responses to pentagastrin (a) during a peak (8 a.m.) and a nadir (4 p.m.) period of endogenous cortisol secretion and (b) when cortisol levels were artificially reduced to low levels by administration of metyrapone. ACTH responses to pentagastrin were identical in the morning and afternoon, despite substantial differences in basal cortisol levels. Suppression of cortisol with metyrapone had little impact on ACTH response to pentagastrin. These data support the hypothesis that CCK-B receptor mediated activation of the HPA axis is relatively resistant to cortisol feedback inhibition. This differentiates it from CRH-mediated activation and raises the possibility that CCK could contribute to acute activation of the HPA axis even in the face of elevated basal cortisol levels, such as those seen in chronic stress or some psychiatric disorders.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Abelson JL,Young EAdoi
10.1016/s0306-4530(02)00013-6keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
169-80issue
2eissn
0306-4530issn
1873-3360pii
S0306453002000136journal_volume
28pub_type
临床试验,杂志文章,随机对照试验abstract：:Distinct patterns of cortisol secretion have been associated with depression in past research, but it remains unclear whether individuals at-risk for depression may also have similar patterns of cortisol secretion. This is the first study to date of both naturalistic diurnal cortisol secretion and cortisol reactivity ...
journal_title：Psychoneuroendocrinology
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abstract：:Suicide is a major cause of death worldwide, responsible for 1.5% of all mortality. The causes of suicidal behavior are not fully understood. Dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity, as measured by cortisol levels, is one potential risk factor. This meta-analytic review aimed (i) to estimate th...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,meta分析,评审
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abstract：:Latino immigrants have lower prevalence of depression, obesity and cardiovascular disease than US-born Latinos when they are recently arrived in the US, but this health advantage erodes with increasing duration of US residence. Cumulative exposure to psychosocial stress and its physiological sequelae may mediate the r...
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,meta分析,评审
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abstract：:The incidence of chronic stress is frequently related to the development of psychiatric disorders like depression. The hypothalamic-pituitary-adrenal (HPA) axis is a major physiological system that mediates the stress response. Tight HPA axis regulation through negative feedback mechanisms is essential for health and ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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abstract：:Decline in the ovarian steroid, estradiol (E(2)), with the menopause transition may influence cognitive and affective processing of older women and there is evidence that hormone replacement therapies (HRTs) with E(2)-mimetics may provide benefit in some, but not all, women. The parameters that play a role in determin...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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abstract：:Females begin to demonstrate greater negative affective responses to stress than males in adolescence. This may reflect the concurrent emergence of underlying differences in physiological response systems, including corticolimbic circuitries, the hypothalamic-pituitary-adrenal axis (HPAA), and the autonomic nervous sy...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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更新日期：2012-08-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.10.018
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更新日期：2013-12-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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更新日期：1983-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,评审
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更新日期：2012-09-01 00:00:00
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