Abstract：
:Opioid administration in males results in opioid-induced androgen deficiency which persists throughout the treatment. In adults, this quickly reverses once opioid administration is suspended. However, less is known about the duration of the effect following drug discontinuation in adolescents. Given the significant implications to sexual maturation in adolescent males, this study examined plasma testosterone levels in both morphine withdrawn mice and their drug-naïve (saline-injected) cage-mates as compared to drug-naïve mice housed physically and visually separate from the morphine-treated mice ('saline only'). Consistent with the literature, plasma testosterone levels in morphine withdrawn adults were reduced on withdrawal day 1 (WD1) and returned to baseline levels by WD9. No significant effects were observed in their saline cage-mates. In the adolescents, no significant differences were observed on WD1 between the morphine withdrawn mice, their saline cage-mates, and the saline only mice - all of which had significantly lower plasma testosterone levels than adults. By WD9, testosterone levels in the saline only adolescent mice had reached adult levels. Notably, plasma testosterone levels were reduced in both the morphine withdrawn adolescent mice and their saline cage-mates, as compared to saline only mice. The effect was not a drug effect per se, given that reduced plasma testosterone levels were not observed in individually housed morphine withdrawn mice. Moreover, our results also suggest that these social effects are not solely explained by stress. These results have numerous implications to the short term and long term health of both adolescents requiring pain management and of adolescent drug addicts.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Hofford RS,Wellman PJ,Eitan Sdoi
10.1016/j.psyneuen.2010.10.008subject
Has Abstractpub_date
2011-06-01 00:00:00pages
728-36issue
5eissn
0306-4530issn
1873-3360pii
S0306-4530(10)00267-2journal_volume
36pub_type
杂志文章abstract：:Intertemporal choices between a smaller sooner and a larger delayed reward are one of the most important types of decisions humans face in their everyday life. The degree to which individuals discount delayed rewards correlates with impulsiveness. Steep delay discounting has been associated with negative outcomes over...
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2011.09.014
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.10.007
更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2014-09-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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更新日期：1988-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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更新日期：2013-07-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.12.009
更新日期：2014-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.09.002
更新日期：2007-09-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2005.02.002
更新日期：2005-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：1998-07-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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更新日期：2019-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,meta分析,评审
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更新日期：2010-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
abstract：:There is a substantial amount of evidence indicating control over ethanol intake by steroid hormones, particularly adrenal glucocorticoids. Thus far, however, studies employing pharmacological methods have failed to find effects of glucocorticoid receptor blockade on voluntary ethanol consumption. Since length of etha...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2003.09.004
更新日期：2004-09-01 00:00:00
abstract：:Patients with long-term remission of Cushing's disease (CD) demonstrate residual psychological complaints. At present, it is not known how previous exposure to hypercortisolism affects psychological functioning in the long-term. Earlier magnetic resonance imaging (MRI) studies demonstrated abnormalities of brain struc...
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pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
