Abstract:
:The differential exposure to circulating steroid hormones during brain development can have lasting consequences on brain function and behavior; therefore, the tight control of steroid hormone action within the developing brain is necessary for the expression of appropriate sex-typical behavior patterns later in life. The restricted control of steroid hormone action at the level of the DNA can be accomplished through the recruitment of coregulatory complexes. Nuclear receptor action can either be enhanced by the recruitment of coactivator complexes or suppressed by the formation of corepressor complexes. Alternatively, the regulation of nuclear receptor-mediated gene transcription in the developing brain may involve a dynamic process of coactivator and corepressor function on DNA. It is likely that understanding how different combinations of coregulatory matrixes assembly on DNA will lead to further understanding of heterogeneous responses to nuclear receptor activation. We will discuss how coregulators influence gene transcription and repression, the role of chromatin-binding factors in the regulation of gene transcription, and their potential impact on brain development.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Auger AP,Jessen HMdoi
10.1016/j.psyneuen.2009.05.012subject
Has Abstractpub_date
2009-12-01 00:00:00pages
S39-47eissn
0306-4530issn
1873-3360pii
S0306-4530(09)00165-6journal_volume
34 Suppl 1pub_type
杂志文章abstract::In humans, oxytocin nasal administration reduces social-threat perception and improves processes involved in communication and the encoding of positive social cues. The aim of this study was to determine whether oxytocin given as an adjunct to exposure therapy improves treatment for social anxiety disorder (SAD) as in...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2009.01.005
更新日期:2009-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.08.031
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journal_title:Psychoneuroendocrinology
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doi:10.1016/j.psyneuen.2016.08.004
更新日期:2016-11-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.104472
更新日期:2020-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.08.028
更新日期:2019-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/0306-4530(93)90025-g
更新日期:1993-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Depressive patients often have altered cortisol secretion, but few studies have investigated genetic variants in relation to both cortisol secretion and depression. To identify genes related to both these conditions, we: (1) tested the association of single nucleotide polymorphisms (SNPs) in hypothalamic-pit...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.01.003
更新日期:2011-08-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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更新日期:1996-04-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2014.12.021
更新日期:2015-03-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.104484
更新日期:2020-03-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.psyneuen.2014.01.008
更新日期:2014-04-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2005.05.003
更新日期:2005-10-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.03.003
更新日期:2016-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.104918
更新日期:2021-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.10.006
更新日期:2019-02-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/s0306-4530(99)00057-8
更新日期:2000-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.08.016
更新日期:2018-12-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.02.026
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.psyneuen.2018.12.233
更新日期:2019-04-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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更新日期:1999-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2019.01.005
更新日期:2019-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2012.12.021
更新日期:2013-09-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.105116
更新日期:2020-12-17 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.104632
更新日期:2020-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/j.psyneuen.2004.03.008
更新日期:2004-11-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.02.001
更新日期:2019-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2013.08.010
更新日期:2013-12-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2008.05.006
更新日期:2008-09-01 00:00:00
abstract::Sex steroids exert important organizational effects on brain structure. Early in life, they are involved in brain sexual differentiation. During puberty, sex steroid levels increase considerably. However, to which extent sex steroid production is involved in structural brain development during human puberty remains un...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2008.09.012
更新日期:2009-04-01 00:00:00