Abstract：
:The relations between stress, HPA-axis, and the immune system have been extensively studied; however, no study to date addressed the joint contribution of immune and HPA biomarkers to the development of anxiety in youth exposed to chronic trauma as mediated by mother-child interaction patterns. A unique cohort of war-exposed children and their mothers, compared to matched controls, were followed from infancy and the current study reports findings from early adolescence (mean age = 11.66, SD = 1.23; N = 111; exposed = 58 control = 53). Youth and mothers' salivary cortisol (CT) and secretory immunoglobulin (s-IgA) levels were measured three times during a 4-hour lab visit, mother-child interaction patterns were quantified from a joint task, and children's anxiety symptoms diagnosed. Trauma-exposed children had higher levels of CT and s-IgA, exhibited more anxiety symptoms, and showed lower social collaboration with mother during the joint task. Trauma-exposed mothers had higher CT and s-IgA levels and showed less supportive parenting during mother-child interaction. Structural equation modeling defined three bio-behavioral paths by which trauma increases anxiety in youth. While the first path charted a behavioral link from exposure to child anxiety via diminished maternal support, the other two paths described mediated biological paths, one through HPA-axis functioning, the other via the immune system. Paths via the child's HPA and immune system were mediated by the parallel maternal variable. Findings are the first to describe the complex bio-behavioral interplay of stress and immune biomarkers and parenting behavior in shaping to the development of risk and resilience trajectories in youth growing up amidst chronic trauma.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Yirmiya K,Djalovski A,Motsan S,Zagoory-Sharon O,Feldman Rdoi
10.1016/j.psyneuen.2018.08.016subject
Has Abstractpub_date
2018-12-01 00:00:00pages
153-160eissn
0306-4530issn
1873-3360pii
S0306-4530(18)30416-5journal_volume
98pub_type
杂志文章abstract：:For the measurement of salivary alpha-amylase (sAA) activity, saliva samples first have to be diluted. There is some evidence for instability, that is, a decline of sAA activity in diluted samples. It is not clear which factors during dilution may contribute to this phenomenon and how quickly this decline of sAA activ...
journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,meta分析,评审
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.10.012
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,评审
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.05.016
更新日期：2013-11-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
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pub_type： 杂志文章,评审
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