Cortisol level measurements in fingernails as a retrospective index of hormone production.

Abstract:

:The cortisol level in fingernails may reflect the hormone's cumulative production over a long period, but the notions have not been fully established. In this study, we investigated the association of cortisol in fingernails with cortisol accumulation over a long period (hair cortisol) and over a relatively short period (salivary cortisol). In study 1, hair and fingernail samples were collected from 58 middle-aged and elderly men. The cortisol level in hair samples was moderately associated with the level in fingernail samples (r = 0.29, p < 0.05 and rs = 0.36, p < 0.01). In study 2, 37 workers provided 4 saliva samples over the course of one day (at awakening, 30 min after awakening, before lunch, and after work) and another set a month later. Further, the workers were asked to provide fingernail samples during a six-month period. We found that the cortisol level in saliva over the whole day (area under the curve for cortisol) was moderately associated with the cortisol level measured in fingernail samples that were collected 4 months (r = 0.43, p < 0.05 and rs = 0.50, p < 0.01) and 5 months later (r = 0.45, p < 0.05 and rs = 0.53, p < 0.01). These results indicated that the cortisol level in fingernail samples might retrospectively represent hormone production during a given period. The cortisol level in fingernail samples may be useful in the investigation of the link between psychosocial stress and health.

journal_title

Psychoneuroendocrinology

authors

Izawa S,Miki K,Tsuchiya M,Mitani T,Midorikawa T,Fuchu T,Komatsu T,Togo F

doi

10.1016/j.psyneuen.2015.01.015

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

24-30

eissn

0306-4530

issn

1873-3360

pii

S0306-4530(15)00029-3

journal_volume

54

pub_type

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