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A new view on hypocortisolism.

Abstract：

:Low cortisol levels have been observed in patients with different stress-related disorders such as chronic fatigue syndrome, fibromyalgia, and post-traumatic stress disorder. Data suggest that these disorders are characterized by a symptom triad of enhanced stress sensitivity, pain, and fatigue. This overview will present data on the development, mechanisms and consequences of hypocortisolism on different bodily systems. We propose that the phenomenon of hypocortisolism may occur after a prolonged period of hyperactivity of the hypothalamic-pituitary-adrenal axis due to chronic stress as illustrated in an animal model. Further evidence suggests that despite symptoms such as pain, fatigue and high stress sensitivity, hypocortisolism may also have beneficial effects on the organism. This assumption will be underlined by some studies suggesting protective effects of hypocortisolism for the individual.

journal_name

Psychoneuroendocrinology

journal_title

Psychoneuroendocrinology

authors

Fries E,Hesse J,Hellhammer J,Hellhammer DH

doi

10.1016/j.psyneuen.2005.04.006

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

1010-6

issue

10

eissn

0306-4530

issn

1873-3360

pii

S0306-4530(05)00089-2

journal_volume

30

pub_type

杂志文章,评审

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