Sexual dysfunction and neuroendocrine correlates of posttraumatic stress disorder in combat veterans: Preliminary findings.


:Sexual dysfunction is not a symptom of PTSD but is a common clinical complaint in trauma survivors with this disorder. In that there are biological parallels in the neuroendocrine processes underlying both PTSD and sexual behavior, we conducted an exploratory investigation of the relationship of PTSD and related neuroendocrine indicators with sexual dysfunction in armed service veterans. Major Depressive Disorder, highly comorbid with PTSD and sexual dysfunction, was also assessed. In veterans with PTSD, sexual problems were associated with plasma DHEA and cortisol, urinary catecholamines, and glucocorticoid sensitivity, even when controlling for the effects of comorbid depression. In a subsample analysis, testosterone levels did not distinguish PTSD or sexual dysfunction, suggesting that sexual problems reported by veterans in this sample were not the result of organic disorder. PTSD did predict higher dihydrotestosterone (DHT) levels, which were associated with sexual problems. More detailed assessment of sexual dysfunction in biologically informed studies of PTSD is warranted to clarify the relationships of PTSD symptomatology and related neurobiology with sexual dysfunction.




Lehrner A,Flory JD,Bierer LM,Makotkine I,Marmar CR,Yehuda R




Has Abstract


2016-01-01 00:00:00












  • A meta-analytic review of the effects of mindfulness meditation on telomerase activity.

    abstract::The enzyme telomerase, through its influence on telomere length, is associated with health and mortality. Four pioneering randomized control trials, including a total of 190 participants, provided information on the effect of mindfulness meditation on telomerase. A meta-analytic effect size of d=0.46 indicated that mi...


    pub_type: 杂志文章,meta分析,评审


    authors: Schutte NS,Malouff JM

    更新日期:2014-04-01 00:00:00

  • Facilitating antidepressant-like actions of estrogens are mediated by 5-HT1A and estrogen receptors in the rat forced swimming test.

    abstract::Previous studies have shown that 17beta-estradiol (E2) induces antidepressant-like actions per se and potentiates those produced by fluoxetine (FLX) in the forced swimming test (FST). The aim of the present work was to explore the participation of serotonin 1A receptors (5-HT1A) and estrogen receptors (ERs) in the ant...


    pub_type: 杂志文章


    authors: Estrada-Camarena E,López-Rubalcava C,Fernández-Guasti A

    更新日期:2006-09-01 00:00:00

  • The cortisol awakening response in relation to objective and subjective measures of waking in the morning.

    abstract::Studies of the salivary cortisol awakening response (CAR) may be confounded by delays between waking in the morning and obtaining the 'waking' salivary sample. We used wrist actigraphy to provide objective information about waking time, and studied the influence of delays in taking the waking sample on the CAR. Eighty...


    pub_type: 杂志文章,多中心研究


    authors: Dockray S,Bhattacharyya MR,Molloy GJ,Steptoe A

    更新日期:2008-01-01 00:00:00

  • The social curse: Evidence for a moderating effect of shared social identity on contagious stress reactions.

    abstract::Contagious stress describes the transmission of a stress response from a distressed individual (target) to an uninvolved observer. Building on social identity theory, we hypothesize that a shared social identity between the observer and the target as compared to a personal identity increases the likelihood of contagio...


    pub_type: 杂志文章


    authors: Schury VA,Nater UM,Häusser JA

    更新日期:2020-12-01 00:00:00

  • Hypothalamic-pituitary adrenal response to cholecystokinin-B receptor agonism is resistant to cortisol feedback inhibition.

    abstract::Intravenous injection of the cholecystokinin (CCK)-B receptor agonist, pentagastrin, produces robust, dose-dependent release of adrenocorticotropin (ACTH) and cortisol, supporting the hypothesis that CCK-B agonists pharmacologically activate the hypothalamic-pituitary-adrenal (HPA) axis. The mechanism of activation an...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Abelson JL,Young EA

    更新日期:2003-02-01 00:00:00

  • Gender differences in corticotropin and corticosterone secretion and corticotropin-releasing factor mRNA expression in the paraventricular nucleus of the hypothalamus and the central nucleus of the amygdala in response to footshock stress or psychological

    abstract::Anorexia nervosa is mostly seen in adolescent females, although the gender-differentiation mechanism is unclear. Corticotropin-releasing factor (CRF), a key peptide for stress responses such as inhibition of food intake, increases in arousal and locomotor activity, and gonadal dysfunction, is thought to be involved in...


    pub_type: 杂志文章


    authors: Iwasaki-Sekino A,Mano-Otagiri A,Ohata H,Yamauchi N,Shibasaki T

    更新日期:2009-02-01 00:00:00

  • Hormonal markers of stress response following interruption of selective serotonin reuptake inhibitor treatment.

    abstract::Depressive illness is associated with loss of the usual regulation of stress-responsive hormonal and neurotransmitter systems, and antidepressants have intrinsic effects reducing the activity of these systems. Abrupt interruption of treatment with some antidepressants has been associated with a self-limited syndrome o...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Michelson D,Amsterdam J,Apter J,Fava M,Londborg P,Tamura R,Pagh L

    更新日期:2000-02-01 00:00:00

  • Perceived stress and hair cortisol: Differences in bipolar disorder and schizophrenia.

    abstract:INTRODUCTION:Bipolar disorder (BD) and schizophrenia (SCZ) are psychiatric disorders with shared and distinct clinical and genetic features. In both disorders, stress increases the risk for onset or relapse and dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis has been reported. The latter is frequently in...


    pub_type: 杂志文章


    authors: Streit F,Memic A,Hasandedić L,Rietschel L,Frank J,Lang M,Witt SH,Forstner AJ,Degenhardt F,Wüst S,Nöthen MM,Kirschbaum C,Strohmaier J,Oruc L,Rietschel M

    更新日期:2016-07-01 00:00:00

  • Maternal chronic stress correlates with serum levels of cortisol, glucose and C-peptide in the fetus, and maternal non chronic stress with fetal growth.

    abstract:INTRODUCTION:During pregnancy, maternal stressors cause changes in both maternal and fetal HPA axes. We therefore investigated the impact of maternal non chronic and chronic stress on fetal glucose metabolism and growth, and serum levels of cortisol in the fetus. MATERIALS AND METHODS:Normal weight pregnant women (n =...


    pub_type: 杂志文章


    authors: Valsamakis G,Papatheodorou D,Chalarakis N,Manolikaki M,Margeli A,Papassotiriou I,Barber TM,Kumar S,Kalantaridou S,Mastorakos G

    更新日期:2020-04-01 00:00:00

  • How childhood trauma and recent adverse events are related to hair cortisol levels in a large adult cohort.

    abstract:BACKGROUND:Exposure to adversity is a risk factor for many mental and somatic health problems. Hypothalamic-pituitary-adrenal (HPA) axis dysregulation is a potential mechanism linking adversity exposure and negative health outcomes. However, associations between adversity exposure and HPA-axis activity have been incons...


    pub_type: 杂志文章


    authors: Oresta S,Vinkers CH,van Rossum EFC,Penninx BWJH,Nawijn L

    更新日期:2021-01-20 00:00:00

  • Effect of long-term estrogen therapy on dopaminergic responsivity in post-menopausal women--a preliminary study.

    abstract::Females have a higher prevalence than men of neuropsychiatric disorders in which dopaminergic abnormalities play a prominent role, e.g. very late-onset schizophrenia and Parkinson's disease (PD). The biological basis of these sex differences is unknown but may include modulation of the dopaminergic system by sex hormo...


    pub_type: 临床试验,杂志文章


    authors: Craig MC,Cutter WJ,Wickham H,van Amelsvoort TA,Rymer J,Whitehead M,Murphy DG

    更新日期:2004-11-01 00:00:00

  • Hair dyeing, hair washing and hair cortisol concentrations among women from the healthy start study.

    abstract:BACKGROUND:Hair cortisol concentration (HCC) has been suggested as a promising marker for chronic stress. However, studies investigating the influence of hair dyeing and hair washing frequency on HCC have shown inconsistent results. OBJECTIVE:To examine associations between HCC and hair dyeing status or weekly hair wa...


    pub_type: 杂志文章


    authors: Kristensen SK,Larsen SC,Olsen NJ,Fahrenkrug J,Heitmann BL

    更新日期:2017-03-01 00:00:00

  • Stress selectively and lastingly promotes learning of context-related high arousing information.

    abstract::The secretion of adrenal stress hormones in response to acute stress is known to affect learning and memory, particularly for emotionally arousing memory material. Here, we investigated whether stress-induced modulation of learning and memory performance depends on (i) the conceptual relatedness between the material t...


    pub_type: 杂志文章


    authors: Smeets T,Wolf OT,Giesbrecht T,Sijstermans K,Telgen S,Joëls M

    更新日期:2009-09-01 00:00:00

  • Autoimmune thyroid disease, left-handedness, and developmental dyslexia.

    abstract::Autoimmune thyroid disease (ATD) (Graves' disease and Hashimoto's thyroiditis) has been one of a number of autoimmune diseases possibly associated with left-handedness, mixed dominance, and learning disability. In the present study, 74 men with ATD were compared to 24 control men with non-ATD. An increased frequency o...


    pub_type: 杂志文章


    authors: Wood LC,Cooper DS

    更新日期:1992-01-01 00:00:00

  • Selective lentiviral-mediated suppression of microRNA124a in the hippocampus evokes antidepressants-like effects in rats.

    abstract::Several lines of evidences suggest that the brain-derived neutrophic factor (BDNF) is implicated in the pathophysiology of depression. However, the molecular mechanisms are not fully understood. In the current study we aimed to investigate how genetic modulation of BDNF in the hippocampus using microRNa124a (miR124a)-...


    pub_type: 杂志文章


    authors: Bahi A,Chandrasekar V,Dreyer JL

    更新日期:2014-08-01 00:00:00

  • Systemic apomorphine alters HPA axis responses to interleukin-1 beta administration but not sound stress.

    abstract::Apomorphine is a dopamine receptor agonist that was recently licensed for the treatment of erectile dysfunction. However, although sexual activity can be stressful, there has been little investigation into whether treatments for erectile dysfunction affect stress responses. We have examined whether a single dose of ap...


    pub_type: 杂志文章


    authors: Buller KM,Crane JW,Spencer SJ,Day TA

    更新日期:2003-08-01 00:00:00

  • Suppression of lymphocyte mitogenesis in different rat strains exposed to footshock during early diurnal and nocturnal time periods.

    abstract::The present study examined stressor interactions with genotype and light/dark cycle. Male Brown Norway (BN), Fischer 344 (F344), Lewis (from two different vendors: Lew/CR and Lew/H) and Sprague Dawley (SD) rats were exposed to footshock either in the early light or early dark circadian phase. Immediately after footsho...


    pub_type: 杂志文章


    authors: Kusnecov AW,Shurin MR,Armfield A,Litz J,Wood P,Zhou D,Rabin BS

    更新日期:1995-01-01 00:00:00

  • Influence of subliminal intragastric fatty acid infusion on subjective and physiological responses to positive emotion induction in healthy women: A randomized trial.

    abstract:BACKGROUND:Subliminal intragastric fatty acid infusion attenuates subjective and brain responses to negative emotion induction. However, the underlying gut-brain signaling mechanisms remain unclear, and it is unknown whether such effect equally applies to positive emotion. OBJECTIVE:We aimed to investigate the interac...


    pub_type: 杂志文章,随机对照试验


    authors: Zhao D,Boey L,Weltens N,Biesiekierski JR,Iven J,Depoortere I,Tack J,Van Oudenhove L

    更新日期:2019-10-01 00:00:00

  • Expression of tumor necrosis factor-alpha and interferon-gamma mRNA in blood cells correlates with depression scores during an acute attack in patients with multiple sclerosis.

    abstract::Depression is a common problem in multiple sclerosis (MS) and affects about 50% of MS patients. Since a dysregulation of cytokine levels has been implicated in the pathogenesis of MS and alterations in cytokine serum levels have been found in depressive illness, we examined the relationship between depressive symptoms...


    pub_type: 杂志文章


    authors: Kahl KG,Kruse N,Faller H,Weiss H,Rieckmann P

    更新日期:2002-08-01 00:00:00

  • Cortisol level measurements in fingernails as a retrospective index of hormone production.

    abstract::The cortisol level in fingernails may reflect the hormone's cumulative production over a long period, but the notions have not been fully established. In this study, we investigated the association of cortisol in fingernails with cortisol accumulation over a long period (hair cortisol) and over a relatively short peri...


    pub_type: 杂志文章


    authors: Izawa S,Miki K,Tsuchiya M,Mitani T,Midorikawa T,Fuchu T,Komatsu T,Togo F

    更新日期:2015-04-01 00:00:00

  • Are the thyroid and adrenal system alterations linked in depression?

    abstract:BACKGROUND:Disturbances in the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-adrenal (HPA) axes have been frequently found in major depression. Given that glucocorticoids may inhibit thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) secretion, it has been hypothesized that hypercortisolemia co...


    pub_type: 杂志文章


    authors: Mokrani MC,Duval F,Erb A,Gonzalez Lopera F,Danila V

    更新日期:2020-12-01 00:00:00

  • Cellular effects of swim stress in the dorsal raphe nucleus.

    abstract::Swim stress regulates forebrain 5-hydroxytryptamine (5-HT) release in a complex manner and its effects are initiated in the serotonergic dorsal raphe nucleus (DRN). The purpose of this study was to examine the effects of swim stress on the physiology of DRN neurons in conjunction with 5-HT immunohistochemistry. Basic ...


    pub_type: 杂志文章


    authors: Kirby LG,Pan YZ,Freeman-Daniels E,Rani S,Nunan JD,Akanwa A,Beck SG

    更新日期:2007-07-01 00:00:00

  • Hormonal influences in developmental learning disabilities.

    abstract::Developmental language and learning disabilities in children can take many different forms and can result from a variety of causes. Research to date has focused primarily on specific disabilities in learning, which are characterized by a significant delay or disorder in one aspect of learning against a background of o...


    pub_type: 杂志文章,评审


    authors: Tallal P

    更新日期:1991-01-01 00:00:00

  • Effects of ECT on the TRH stimulation test.

    abstract::The prognostic value of the TRH stimulation test was evaluated in 23 inpatients with major depressive disorder before and after a trial of ECT. In contrast to previous reports, the peak TSH response to TRH was significantly decreased after treatment compared with before treatment. This effect was consistent across ind...


    pub_type: 杂志文章


    authors: Decina P,Sackeim HA,Kahn DA,Pierson D,Hopkins N,Malitz S

    更新日期:1987-01-01 00:00:00

  • Mental health and its associations with glucose-lowering medication in women with gestational diabetes mellitus. A prospective clinical cohort study.

    abstract:AIMS:Mental health symptoms are frequent in women with gestational diabetes mellitus (GDM) and may influence glycemic control. We therefore investigated if mental health symptoms (high depression and low well-being scores) predicted a need for glucose-lowering medication and if this use of medication influenced the tra...


    pub_type: 杂志文章


    authors: Gilbert L,Nikolaou A,Quansah DY,Rossel JB,Horsch A,Puder JJ

    更新日期:2020-12-01 00:00:00

  • The glucocorticoid receptor antagonist mifepristone reduces ethanol intake in rats under limited access conditions.

    abstract::There is a substantial amount of evidence indicating control over ethanol intake by steroid hormones, particularly adrenal glucocorticoids. Thus far, however, studies employing pharmacological methods have failed to find effects of glucocorticoid receptor blockade on voluntary ethanol consumption. Since length of etha...


    pub_type: 杂志文章


    authors: Koenig HN,Olive MF

    更新日期:2004-09-01 00:00:00

  • Improving infants' stress-induced cortisol regulation through attachment-based intervention: A randomized controlled trial.

    abstract::Attachment-based parenting interventions have shown positive effects on early cortisol regulation, a key biomarker. Evaluations to date have focused on diurnal cortisol production in high-risk infants. It is important to understand whether attachment-based intervention may also improve stress-induced cortisol producti...


    pub_type: 杂志文章,随机对照试验


    authors: Berlin LJ,Martoccio TL,Bryce CI,Jones Harden B

    更新日期:2019-05-01 00:00:00

  • Differences in the response to the combined DEX-CRH test between PTSD patients with and without co-morbid depressive disorder.

    abstract:BACKGROUND:Neuroendocrine studies have shown profound alterations in HPA-axis regulation in posttraumatic stress disorder (PTSD). Based on baseline assessments and the response to dexamethasone, a hypothalamic overdrive with enhanced glucocorticoid feedback inhibition has been suggested. The dexamethasone-corticotrophi...


    pub_type: 杂志文章


    authors: de Kloet C,Vermetten E,Lentjes E,Geuze E,van Pelt J,Manuel R,Heijnen C,Westenberg H

    更新日期:2008-04-01 00:00:00

  • T4 and waist:hip ratio as biomarkers of antipsychotic-induced weight gain in Han Chinese inpatients with schizophrenia.

    abstract::Second-generation antipsychotic agents (SGAs) cause serious metabolic side effects, including weight gain, dyslipidemia, and glucose metabolism abnormalities, which occur by unknown mechanisms. Therefore, the search for prospective markers for antipsychotic-induced weight gain (AIWG) has been of major interest. So far...


    pub_type: 杂志文章


    authors: Li S,Gao Y,Lv H,Zhang M,Wang L,Jiang R,Xu C,Wang X,Gao M,He Y,Li J,Li WD

    更新日期:2018-02-01 00:00:00

  • Steroid-induced elevation of glucose in Alzheimer's disease: relationship to gender, apolipoprotein E genotype and cognition.

    abstract::Glucose and insulin may play an important role in the pathophysiology and symptomatology of Alzheimers disease (AD), and prior studies suggest interactions among glucose, insulin, gender and apolipoprotein E genotype. We analyzed the relationship between steroid-induced glucose elevation and gender, presence of the ap...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Aisen PS,Berg JD,Craft S,Peskind ER,Sano M,Teri L,Mulnard RA,Thomas RG,Thal LJ

    更新日期:2003-01-01 00:00:00