Brain sensitization to external and internal stimuli.


:Sensitization is defined as a non-associative learning process occurring when repeated administrations of a stimulus result in a progressive amplification of a response (Shettleworth, 2010). The purpose of this review paper is to discuss whether brain sensitization is helpful in common health problems in man. The paper reviews data on brain sensitization covering increased behavioral, physiological, cognitive, and emotional responses in man and animals. The paper concludes that brain sensitization may be a helpful concept to understand subjective and "unexplained" health complaints (nonspecific muscle pain, mood changes, fatigue, and gastrointestinal complaints), and, therefore, relevant for evidence based treatment and prevention of these common health problems.




Ursin H




Has Abstract


2014-04-01 00:00:00












  • Thyroid stimulating hormone, free thyroxine and cognitive ability in old age: the Lothian Birth Cohort Study 1936.

    abstract::The current study investigated the associations between thyroid stimulating hormone (TSH), free thyroxine (T(4)) and cognitive ability (general ability, memory and processing speed), in a large age homogenous sample (n=659) of generally healthy euthyroid older adults. Associations were considered both at baseline (mea...


    pub_type: 杂志文章


    authors: Booth T,Deary IJ,Starr JM

    更新日期:2013-04-01 00:00:00

  • Frontal lobe proton magnetic-resonance spectroscopy in Graves' disease: a pilot study.

    abstract::Patients with hyperthyroidism may show impaired performance on several neuropsychological tests that require complex visual discrimination, conceptualization, mental flexibility or organization. These neurocognitive impairments appear to be consistent with prefrontal lobe dysfunction. This pilot study was undertaken t...


    pub_type: 临床试验,杂志文章


    authors: Bhatara VS,Tripathi RP,Sankar R,Gupta A,Khushu S

    更新日期:1998-08-01 00:00:00

  • Cortisol circadian rhythms and response to stress in children with autism.

    abstract:BACKGROUND:Autism is a severe neurodevelopmental disorder characterized by impairment in communication, social interaction, repetitive behaviors and difficulty adapting to novel experiences. The Hypothalamic-Pituitary-Adrenocortical (HPA) system responds consistently to perceived novel or unfamiliar situations and can ...


    pub_type: 杂志文章


    authors: Corbett BA,Mendoza S,Abdullah M,Wegelin JA,Levine S

    更新日期:2006-01-01 00:00:00

  • Perceived control moderates the influence of active coping on salivary cortisol response to acute pain among women but not men.

    abstract::It is generally established that active-coping strategies and greater perceived control over pain are associated with improved pain-related outcomes; however, it remains unclear whether these factors independently or interactively influence adrenocortical function in reaction to a painful stimulus. The present study e...


    pub_type: 杂志文章


    authors: Bento SP,Goodin BR,Fabian LA,Page GG,Quinn NB,McGuire L

    更新日期:2010-07-01 00:00:00

  • Anticipatory sensitization to repeated stressors: the role of initial cortisol reactivity and meditation/emotion skills training.

    abstract::Anticipation may play a role in shaping biological reactions to repeated stressors-a common feature of modern life. We aimed to demonstrate that: (a) individuals who display a larger cortisol response to an initial stressor exhibit progressive anticipatory sensitization, showing progressively higher cortisol levels be...


    pub_type: 杂志文章,随机对照试验


    authors: Turan B,Foltz C,Cavanagh JF,Wallace BA,Cullen M,Rosenberg EL,Jennings PA,Ekman P,Kemeny ME

    更新日期:2015-02-01 00:00:00

  • ADP ribosyl-cyclases (CD38/CD157), social skills and friendship.

    abstract::Why some individuals seek social engagement while others shy away has profound implications for normal and pathological human behavior. Evidence suggests that oxytocin (OT), the paramount human social hormone, and CD38 that governs OT release, contribute to individual differences in social skills from intense social i...


    pub_type: 杂志文章


    authors: Chong A,Malavasi F,Israel S,Khor CC,Yap VB,Monakhov M,Chew SH,Lai PS,Ebstein RP

    更新日期:2017-04-01 00:00:00

  • Effects of ECT on the TRH stimulation test.

    abstract::The prognostic value of the TRH stimulation test was evaluated in 23 inpatients with major depressive disorder before and after a trial of ECT. In contrast to previous reports, the peak TSH response to TRH was significantly decreased after treatment compared with before treatment. This effect was consistent across ind...


    pub_type: 杂志文章


    authors: Decina P,Sackeim HA,Kahn DA,Pierson D,Hopkins N,Malitz S

    更新日期:1987-01-01 00:00:00

  • Day length predicts investment in human immune function: Shorter days yield greater investment.

    abstract::Winter is characterized by stressful conditions which compromise health and render animals more vulnerable to infection and illness than during other times of the year. Organisms are hypothesized to adapt to these seasonal stressors by increasing investment in immune function in response to diminished photoperiod dura...


    pub_type: 杂志文章


    authors: Gassen J,Proffitt Leyva RP,Mengelkoch S,White JD,Peterman JL,Prokosch ML,Bradshaw HK,Eimerbrink MJ,Corrigan EK,Cheek DJ,Boehm GW,Hill SE

    更新日期:2019-09-01 00:00:00

  • Prenatal testosterone exposure is associated with delay of gratification and attention problems/overactive behavior in 3-year-old boys.

    abstract::Sex differences in self-control become apparent during preschool years. Girls are better able to delay their gratification and show less attention problems and overactive behavior than boys. In this context, organizational effects of gonadal steroids affecting the neural circuitry underlying self-control could be resp...


    pub_type: 杂志文章


    authors: Körner LM,Pause BM,Meinlschmidt G,Tegethoff M,Fröhlich S,Kozlowski P,Rivet N,Jamey C,Reix N,Kintz P,Raul JS,Heil M

    更新日期:2019-06-01 00:00:00

  • Histories of abuse predict stronger within-person covariation of ovarian steroids and mood symptoms in women with menstrually related mood disorder.

    abstract:OBJECTIVE:Individual differences in sensitivity to cyclical changes in ovarian steroids estradiol (E2) and progesterone (P4) have been implicated in the pathophysiology of menstrually related mood disorder (MRMD). However, no prospective studies have investigated psychosocial risk factors for sensitivity to hormone eff...


    pub_type: 杂志文章


    authors: Eisenlohr-Moul TA,Rubinow DR,Schiller CE,Johnson JL,Leserman J,Girdler SS

    更新日期:2016-05-01 00:00:00

  • Blunted basal corticosterone pulsatility predicts post-exposure susceptibility to PTSD phenotype in rats.

    abstract::The basal activity of the hypothalamic-pituitary-adrenal axis is highly dynamic and is characterized by both circadian and ultradian (pulsatile) patterns of hormone secretion. Pulsatility of glucocorticoids has been determined to be critical for optimal transcriptional, neuroendocrine, and behavioral responses. We use...


    pub_type: 杂志文章


    authors: Danan D,Matar MA,Kaplan Z,Zohar J,Cohen H

    更新日期:2018-01-01 00:00:00

  • Endocrine and psychological stress responses in a simulated emergency situation.

    abstract:BACKGROUND:Several studies have assessed the effects of training using patient simulation systems on medical skills. However, endocrine and psychological stress responses in a patient simulation situation and the relationship between stress reactivity and medical performance have been studied rarely, so far. METHODS:M...


    pub_type: 杂志文章,随机对照试验


    authors: Keitel A,Ringleb M,Schwartges I,Weik U,Picker O,Stockhorst U,Deinzer R

    更新日期:2011-01-01 00:00:00

  • Effects of gender and personality on everyday moral decision-making after acute stress exposure.

    abstract::Exposure to acute psychosocial stress has been shown to affect moral decision-making, though little is known about potential gender differences or effects of personality. In two within-subjects design studies, 179 healthy men and women (N = 99 in Study 1, N = 80 in Study 2) were exposed to the Trier Social Stress Test...


    pub_type: 杂志文章


    authors: Singer N,Sommer M,Wüst S,Kudielka BM

    更新日期:2020-12-01 00:00:00

  • Longitudinal hypothalamic-pituitary-adrenal axis trait and state effects in recurrent depression.

    abstract:BACKGROUND:Hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity has been observed in (recurrent) major depressive disorder (MDD), although inconsistently and mainly cross-sectional. Longitudinal studies clarifying state-trait issues are lacking. We aimed to determine whether HPA-axis (hyper)activity in recurrent MDD...


    pub_type: 杂志文章,随机对照试验


    authors: Lok A,Mocking RJ,Ruhé HG,Visser I,Koeter MW,Assies J,Bockting CL,Olff M,Schene AH

    更新日期:2012-07-01 00:00:00

  • Influence of pimozide on hypothalamo-pituitary function in children with behavioral disorders.

    abstract::Hypothalamo-pituitary functions were examined in thirteen children with behavioral disorders (six with hyperkinesia, four with autism, two with tic and one with schizophrenia) before and during treatment with pimozide, an antidopaminergic drug. The mean (+/- S.E.M.) basal serum PRL level (24.5 +/- 4.2 ng/ml) during pi...


    pub_type: 杂志文章


    authors: Suwa S,Naruse H,Ohura T,Tsuruhara T,Takesada M,Yamazaki K,Mikuni M

    更新日期:1984-01-01 00:00:00

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    abstract::Oxytocin receptors in several regions of the limbic system are regulated by gonadal steroids and play an important role in the mediation of maternal, sexual and affiliative behaviors. We have previously reported oxytocin receptor regulation by glucocorticoids in hippocampus and subiculum-neuroanatomical regions implic...


    pub_type: 杂志文章


    authors: Liberzon I,Young EA

    更新日期:1997-08-01 00:00:00

  • Metabolic dysregulation in older adults with depression and loneliness: The ATHLOS study.

    abstract::This study aimed to examine how loneliness contributes to metabolic dysregulation among older adults with depression and determine the relative contribution of loneliness to the development of chronic diseases in late adulthood. Harmonised data from the Ageing Trajectories of Health: Longitudinal Opportunities and Syn...


    pub_type: 杂志文章


    authors: de la Torre-Luque A,Lara E,de la Fuente J,Rico-Uribe LA,Caballero FF,Lopez-Garcia P,Sanchez-Niubo A,Bobak M,Koskinen S,Haro JM,Ayuso-Mateos JL

    更新日期:2021-01-01 00:00:00

  • The relationship of depression and diabetes: pathophysiological and treatment implications.

    abstract::Diabetes is a highly prevalent, chronic disease that requires ongoing, multi-specialty medical care combined with patient self-management, family support, and education to prevent or delay end-organ morbidity and mortality. There is clearly an increased prevalence of major depressive disorder, a relatively common and ...


    pub_type: 杂志文章,评审


    authors: Rustad JK,Musselman DL,Nemeroff CB

    更新日期:2011-10-01 00:00:00

  • Challenges for measuring oxytocin: The blind men and the elephant?

    abstract::Since its discovery more than a century ago, oxytocin has become one of the most intensively studied molecules in behavioral biology. In the last five years, Psychoneuroendocrinology has published more than 500 articles with oxytocin in the title, with many of these articles including measures of endogenous oxytocin c...


    pub_type: 杂志文章,评审


    authors: MacLean EL,Wilson SR,Martin WL,Davis JM,Nazarloo HP,Carter CS

    更新日期:2019-09-01 00:00:00

  • Comparison of growth hormone stimulation induced by desimipramine, diazepam and metaclazepam in man.

    abstract::A comparison of the effect on growth hormone (GH) stimulation in men (n = 6) of desimipramine (DMI), a tricyclic antidepressant, and of the benzodiazepine derivatives diazepam and metaclazepam with that of a placebo, showed that only DMI caused a significant (p less than 0.01) GH stimulation. After DMI, all six subjec...


    pub_type: 临床试验,杂志文章


    authors: Laakmann G,Treusch J,Schmauss M,Schmitt E,Treusch U

    更新日期:1982-01-01 00:00:00

  • Parental separation in childhood and adult inflammation: the importance of material and psychosocial pathways.

    abstract:BACKGROUND:Childhood adversities are known to be associated with poorer health outcomes. A potential mechanism may be through changes in inflammatory processes. One such childhood adversity is separation of parents, however relatively little is known about the association between parental separation and inflammation in...


    pub_type: 杂志文章


    authors: Lacey RE,Kumari M,McMunn A

    更新日期:2013-11-01 00:00:00

  • Peri-pubertal gonadotropin-releasing hormone agonist treatment affects sex biased gene expression of amygdala in sheep.

    abstract::The nature of hormonal involvement in pubertal brain development has attracted wide interest. Structural changes within the brain that occur during pubertal development appear mainly in regions closely linked with emotion, motivation and cognitive functions. Using a sheep model, we have previously shown that peri-pube...


    pub_type: 杂志文章


    authors: Nuruddin S,Krogenæs A,Brynildsrud OB,Verhaegen S,Evans NP,Robinson JE,Haraldsen IR,Ropstad E

    更新日期:2013-12-01 00:00:00

  • Initial urinary epinephrine and cortisol levels predict acute PTSD symptoms in child trauma victims.

    abstract:BACKGROUND:Previous research examining biological correlates of posttraumatic stress disorder (PTSD) in children has suggested that children with chronic PTSD have altered levels of catecholamines and cortisol compared to similarly traumatized children who do not meet diagnostic criteria. The present study extended the...


    pub_type: 临床试验,杂志文章


    authors: Delahanty DL,Nugent NR,Christopher NC,Walsh M

    更新日期:2005-02-01 00:00:00

  • Environmental enrichment improves metabolic and behavioral health in the BTBR mouse model of autism.

    abstract::BTBR T + Itpr3tf/J (BTBR) mice are an Autism Spectrum Disorder (ASD)-like model that exhibit behavioral and physiological deficits similar to those observed in patients with ASD. While behavioral therapy is a first line of treatment in ASD patients, comparable non-pharmacological treatments are less explored in murine...


    pub_type: 杂志文章


    authors: Queen NJ,Boardman AA,Patel RS,Siu JJ,Mo X,Cao L

    更新日期:2020-01-01 00:00:00

  • T4 and waist:hip ratio as biomarkers of antipsychotic-induced weight gain in Han Chinese inpatients with schizophrenia.

    abstract::Second-generation antipsychotic agents (SGAs) cause serious metabolic side effects, including weight gain, dyslipidemia, and glucose metabolism abnormalities, which occur by unknown mechanisms. Therefore, the search for prospective markers for antipsychotic-induced weight gain (AIWG) has been of major interest. So far...


    pub_type: 杂志文章


    authors: Li S,Gao Y,Lv H,Zhang M,Wang L,Jiang R,Xu C,Wang X,Gao M,He Y,Li J,Li WD

    更新日期:2018-02-01 00:00:00

  • Maternal serum concentrations of BDNF and depression in the perinatal period.

    abstract::There is accumulating evidence that a deficiency in brain-derived neurotrophic factor (BDNF) plays a critical role in the pathophysiology of depression. This is in line with the postulate that low BDNF levels in serum are associated with depression. However, the regulation of maternal BDNF serum levels in the perinata...


    pub_type: 杂志文章


    authors: Lommatzsch M,Hornych K,Zingler C,Schuff-Werner P,Höppner J,Virchow JC

    更新日期:2006-04-01 00:00:00

  • Testosterone across successive competitions: evidence for a 'winner effect' in humans?

    abstract::In many species testosterone fluctuates in concert with outcome-dependent changes in social status, such that winning a competition leads to an increase in circulating testosterone (i.e., competition effect). Although this phenomenon has been well studied in humans, the cumulative endocrine impact of multiple successi...


    pub_type: 杂志文章,随机对照试验


    authors: Zilioli S,Watson NV

    更新日期:2014-09-01 00:00:00

  • Changes in testosterone mediate the effect of winning on subsequent aggressive behaviour.

    abstract::Testosterone concentrations rise rapidly in the context of competitive interactions and remain elevated in winners relative to losers. Theoretical models suggest that this divergent neuroendocrine response serves to mediate future dominance behaviours. Although research in animal models provides compelling support for...


    pub_type: 杂志文章,随机对照试验


    authors: Carré JM,Campbell JA,Lozoya E,Goetz SM,Welker KM

    更新日期:2013-10-01 00:00:00

  • Use of an estradiol-based combined oral contraceptives has no influence on attentional bias or depressive symptoms in healthy women.

    abstract::Combined oral contraceptive (COC) use is associated with small, albeit significant, increases in mental symptom scores, predominantly irritability, depressed mood, and anxiety. Yet, randomized prospective trials are needed to better characterize the women at risk for COC-induced negative mood change. Thus, the primary...


    pub_type: 杂志文章,随机对照试验


    authors: Scheuringer A,Lundin C,Derntl B,Pletzer B,Sundström Poromaa I

    更新日期:2020-03-01 00:00:00

  • Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response.

    abstract:BACKGROUND:Metabolism of dietary fatty acids (FAs), and its relationship with the hypothalamic-pituitary-adrenal (HPA)-axis, have been found to be altered in major depressive disorder (MDD). Moreover, indications exist that these factors are associated with antidepressant-response. If we better understand these associa...


    pub_type: 杂志文章,随机对照试验


    authors: Mocking RJ,Verburg HF,Westerink AM,Assies J,Vaz FM,Koeter MW,Ruhé HG,Schene AH

    更新日期:2015-09-01 00:00:00