Abstract：
:Sensitization is defined as a non-associative learning process occurring when repeated administrations of a stimulus result in a progressive amplification of a response (Shettleworth, 2010). The purpose of this review paper is to discuss whether brain sensitization is helpful in common health problems in man. The paper reviews data on brain sensitization covering increased behavioral, physiological, cognitive, and emotional responses in man and animals. The paper concludes that brain sensitization may be a helpful concept to understand subjective and "unexplained" health complaints (nonspecific muscle pain, mood changes, fatigue, and gastrointestinal complaints), and, therefore, relevant for evidence based treatment and prevention of these common health problems.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Ursin Hdoi
10.1016/j.psyneuen.2014.01.008subject
Has Abstractpub_date
2014-04-01 00:00:00pages
134-45eissn
0306-4530issn
1873-3360pii
S0306-4530(14)00022-5journal_volume
42pub_type
杂志文章,评审abstract：:A number of studies have now examined the association between smoking and the magnitude of physiological reactions to acute psychological stress. However, no large-scale study has demonstrated this association incorporating neuroendocrine in addition to cardiovascular reactions to stress. The present study compared ne...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2014.05.023
更新日期：2014-10-01 00:00:00
abstract：:Interpersonal touch is frequently used for communicating emotions, strengthen social bonds and to give others pleasure. The neuropeptide oxytocin increases social interest, improves recognition of others' emotions, and it is released during touch. Here, we investigated how oxytocin and gentle human touch affect social...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.09.017
更新日期：2014-01-01 00:00:00
abstract：:Cortisol administration prior to treatment can promote the efficacy of exposure-based treatments in specific phobia: cortisol has been proposed to reduce fear retrieval at the beginning of exposure and to enhance the acquisition and consolidation of corrective information learned during exposure. Whether cortisol exer...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2018.09.015
更新日期：2019-01-01 00:00:00
abstract：:In the field of depression, inflammation-associated depression stands up as an exception since its causal factors are obvious and it is easy to mimic in an animal model. In addition, quasi-experimental studies can be carried out in patients who are treated chronically with recombinant cytokines for a medical condition...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2010.09.012
更新日期：2011-04-01 00:00:00
abstract：:Swim stress regulates forebrain 5-hydroxytryptamine (5-HT) release in a complex manner and its effects are initiated in the serotonergic dorsal raphe nucleus (DRN). The purpose of this study was to examine the effects of swim stress on the physiology of DRN neurons in conjunction with 5-HT immunohistochemistry. Basic ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.05.001
更新日期：2007-07-01 00:00:00
abstract：:Cortisol, the primary glucocorticoid (GC) in humans, influences neuronal excitability and plasticity by acting on mineralocorticoid and glucocorticoid receptors. Cellular studies demonstrated that elevated GC levels affect neuronal plasticity, for example through a reduction of hippocampal long-term potentiation (LTP)...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2016.12.002
更新日期：2017-03-01 00:00:00
abstract：:Determinations of gonadotropins and testosterone were performed in 22 men with hypospadias (H), seven male-to-female transsexuals (T) and in 16 normal men (N), all of similar age. The response of serum FSH and LH to GnRH was determined in six subjects in each group. Oligospermia was found in five of 13 patients with H...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(86)90032-6
更新日期：1986-01-01 00:00:00
abstract：:Sex steroids exert important organizational effects on brain structure. Early in life, they are involved in brain sexual differentiation. During puberty, sex steroid levels increase considerably. However, to which extent sex steroid production is involved in structural brain development during human puberty remains un...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2008.09.012
更新日期：2009-04-01 00:00:00
abstract：:Fifty-eight normal cycle, healthy women were confronted with an aversive, anger-provoking situation in the laboratory. Eighteen women were tested in their follicular phase. A further 40 women were tested in the premenstrual phase, half of whom reported suffering from complaints of premenstrual emotional lability and i...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(95)00022-4
更新日期：1996-07-01 00:00:00
abstract：:Sociality is a fundamental aspect of human behavior and health. One benefit of affiliative social relationships is reduced short-term levels of glucocorticoids (GCs), which are indicative of physiological stress. Less is known, however, about chronic GC production in relation to affiliative social behavior. To address...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2017.06.018
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Disturbances in the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-adrenal (HPA) axes have been frequently found in major depression. Given that glucocorticoids may inhibit thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) secretion, it has been hypothesized that hypercortisolemia co...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.104831
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:Major Depression (MD) results from a complex interplay between environmental stressors and biological factors. Previous studies in adults have shown that adverse life events interact with genetic variation in FKBP5, a gene implicated in the stress-response system, to predict depressive symptoms and MD. This i...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.03.025
更新日期：2019-08-01 00:00:00
abstract：:Research has suggested that stressful situations lead to a decrease in testosterone, whereas concern with one's social status increases testosterone. However, results from studies examining testosterone reactivity in stressful situations that involve evaluation by others (hence status concerns) are inconsistent. Furth...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2014.05.007
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:A proportion of patients with panic disorder (PD) fail to show a remission after psychotherapy. Biological correlates of psychotherapy non-response have rarely been described in the literature. The aim of the present study was to research the relationship between the cortisol stress response and the psychoth...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.11.030
更新日期：2017-03-01 00:00:00
abstract：:We have studied the effects of ketanserin, a specific 5-HT2 antagonist, and zimelidine, a selective inhibitor of 5-HT re-uptake into central nervous system presynaptic terminals, upon basal and TRH stimulated serum TSH and prolactin levels in euthyroid individuals. Ten normal volunteers were studied (five male and fiv...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(84)90017-9
更新日期：1984-01-01 00:00:00
abstract：:For the measurement of salivary alpha-amylase (sAA) activity, saliva samples first have to be diluted. There is some evidence for instability, that is, a decline of sAA activity in diluted samples. It is not clear which factors during dilution may contribute to this phenomenon and how quickly this decline of sAA activ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.104847
更新日期：2020-11-01 00:00:00
abstract：:The present study examines the hypothesis that exposure to anabolic-androgenic steroids (AAS) during adolescent development predisposes hamsters to heightened levels of aggressive behavior by influencing the anterior hypothalamic-arginine vasopressin (AH-AVP) neural system. To test this, adolescent male hamsters (Meso...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(99)00057-8
更新日期：2000-05-01 00:00:00
abstract：:Successful mental aging may be defined as maintenance of youthful attitudes, cognitive and adaptational processes despite advanced age. Maintenance of homeostasis and efficient adaptational processes are of utmost importance. It is suggested that multiple hormonal systems and processes are involved in the multidimensi...
journal_title：Psychoneuroendocrinology
pub_type：
doi：10.1016/s0306-4530(03)00130-6
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:Chronic psychosocial stress is a crucial risk factor in the development of many diseases including obesity. Neuropeptide Y (NPY), distributed throughout the peripheral and central nervous system, is believed to pay a role in the pathophysiologic relationship between stress and obesity. Although several anima...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.03.003
更新日期：2016-07-01 00:00:00
abstract：:Latino immigrants have lower prevalence of depression, obesity and cardiovascular disease than US-born Latinos when they are recently arrived in the US, but this health advantage erodes with increasing duration of US residence. Cumulative exposure to psychosocial stress and its physiological sequelae may mediate the r...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2017.08.018
更新日期：2017-11-01 00:00:00
abstract：:Sustained abnormalities of glucocorticoid levels have been associated with neuropsychiatric illnesses such as major depression, posttraumatic stress disorder (PTSD), panic disorder, and obsessive compulsive disorder. The pathophysiological effects of glucocorticoids may depend not only on the amount of glucocorticoid ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2008.06.001
更新日期：2008-10-01 00:00:00
abstract：:The nature of hormonal involvement in pubertal brain development has attracted wide interest. Structural changes within the brain that occur during pubertal development appear mainly in regions closely linked with emotion, motivation and cognitive functions. Using a sheep model, we have previously shown that peri-pube...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.09.011
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Raised maternal anxiety during pregnancy is associated with increased risk of adverse neurodevelopmental outcomes for her child. The mechanisms underlying this are not known but animal studies suggest prenatal stress may alter the function of the placenta. Here we determined whether maternal prenatal anxiety...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2011.09.014
更新日期：2012-06-01 00:00:00
abstract：:The role of opioid receptors in infant-mother attachment has been well established. Morphine, a preferential μ opioid receptor (MOR) agonist, attenuates separation distress vocalizations and decreases physical contact between infant and mother. However, there is little research on how opioid receptors are involved in ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.05.009
更新日期：2013-11-01 00:00:00
abstract：:Significant emotional and physical symptoms have been linked to hormonal changes during the menstrual cycle. A critical evaluation of the available studies questions the commonly held belief in menstrual-cycle-related complaints in the majority of normal women. The present study investigated changes in mood, somatic c...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(90)90021-z
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:The hypothalamic-pituitary-adrenal (HPA) axis is a critical mediator linking stress to health. Understanding how to modulate its reactivity could potentially help reduce the detrimental health effects of HPA axis activation. Social evaluative threat is a potent activator of this system. Access to control and...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2014.02.016
更新日期：2014-06-01 00:00:00
abstract：:Antidepressants such as SSRIs or mirtazapine have been demonstrated to increase the concentrations of 3alpha-reduced neuroactive steroids throughout several weeks of treatment. However, no data are available on the impact of mood stabilizers such as lithium or carbamazepine on neuroactive steroid levels in depressed p...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.04.004
更新日期：2007-07-01 00:00:00
abstract：:Estrogen secretion in young women follows a cyclic pattern characterized by a pronounced surge in estrogen around ovulation. The way in which this estrogen peak affects cognitive functioning is unclear. Short-term estrogen treatment for a few days mimicking normal pre-menopausal estrogen dynamics substantially enhance...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2006.05.007
更新日期：2006-09-01 00:00:00
abstract：:This study was designed to investigate the relationship between selective attention to social threat and neuroendocrine activity. Selective attention to social threat was measured using a supraliminal (unmasked) and a subliminal (masked) version of a pictorial emotional Stroop task, comparing color-naming latencies of...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(00)00011-1
更新日期：2000-08-01 00:00:00
abstract：:Estrogen regulates neuroendocrine and inflammatory processes that play critical roles in neuroinflammation, anxiety, and chronic pain. Patients suffering from chronic pain often complain of anxiety. However, limited information is available regarding the neural circuitry of chronic pain-related anxiety and the related...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2014.12.021
更新日期：2015-03-01 00:00:00
