Abstract:
BACKGROUND:Chronic psychosocial stress is a crucial risk factor in the development of many diseases including obesity. Neuropeptide Y (NPY), distributed throughout the peripheral and central nervous system, is believed to pay a role in the pathophysiologic relationship between stress and obesity. Although several animal studies have investigated the impact on obesity of interactions between NPY single nucleotide polymorphisms (SNPs) and stress, the same remains to be analyzed in humans. METHODS:To identify NPY gene-by-stress interaction effects on human obesity, we analyzed the interaction between four NPY SNPs and stress with obesity-related traits, including visceral adipose tissue (VAT). A total of 1468 adult subjects were included for this analysis. RESULTS:In a SNP-only model without interaction with stress, no significant SNPs were found (pSNP>0.05). However, NPY SNPs-by-stress interaction effects were significantly linked to body mass index (BMI), waist circumference, and VAT (pint<0.05), even though a significant interaction effect for rs16135 on BMI was not identified. These significant interaction effects were also detected in interaction results for the binary traits of obesity. Among the obesity traits, mean changes of VAT by increased stress levels in homozygous risk allele carriers were the greatest (range of mean increases for four SNPs (min-max)=12.57cm(2)-29.86cm(2)). CONCLUSIONS:This study suggests that common polymorphisms for NPY were associated with human obesity by interacting with psychosocial stress, emphasizing the need for stress management in obesity prevention.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Kim HJ,Min KB,Min JYdoi
10.1016/j.psyneuen.2016.03.003subject
Has Abstractpub_date
2016-07-01 00:00:00pages
10-5eissn
0306-4530issn
1873-3360pii
S0306-4530(16)30065-8journal_volume
69pub_type
杂志文章abstract::Apart from its action as gonadotropin releasing factor, luteinizing hormone-releasing hormone (LHRH) is a potent regulator of sexual behaviour in animals. The present study aimed to assess a similar role of LHRH for sexuality in humans. In a double-blind placebo-controlled and randomized study, effects of human LHRH a...
journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-01-01 00:00:00
abstract::The neuropeptides thyrotropin releasing hormone (TRH) and prolactin (PRL), which affect various behaviors in animals, showed "antidepressant" properties in an experimental model of depression. Subcutaneous administration of TRH reduced the total immobility time of rats tested in the despair (constrained swim) test and...
journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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doi:10.1016/j.psyneuen.2011.07.021
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/0306-4530(93)90060-x
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pub_type: 临床试验,杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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更新日期:1988-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.02.010
更新日期:2019-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(94)90046-9
更新日期:1994-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2010.12.002
更新日期:2011-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0306-4530(03)00097-0
更新日期:2003-08-01 00:00:00