Abstract：
:Multiple lines of evidence indicate that patients with chronic schizophrenia (SCZ) display executive dysfunction across the illness course. However, the potential molecular pathophysiologic mechanisms remain poorly elucidated. Neurodevelopmental changes caused by alterations of inflammatory mediators and neurotrophins have been shown to occur in the earliest stages of SCZ, and be associated with executive dysfunction (ED) in SCZ. Therefore, the current study was to investigate whether the interplay between BDNF and inflammatory mediators was involved in the disruption of executive function of long-term hospitalized patients with chronic SCZ. Serum cytokines and BDNF levels were measured in 112 long-term hospitalized patients with chronic SCZ and 44 healthy normal controls. Executive functions were assessed by verbal fluency tests (VFT), the Stroop word-color test (Stroop), and the Wisconsin card sorting tests (WCST).The results showed that the patients had higher IL-2, IL-6, IL-8, but lower TNF-α and BDNF compared to control subjects. In the patient group, BDNF was positively associated with IL-2 and IL-8 levels, while lower BDNF levels were correlated with ED measured by VFT and WCST tests. Multiple stepwise regression analyses confirmed that BDNF × IL-8 and BDNF × TNF-α were factors influencing the total score of VFT, while BDNF × IL-8 and BDNF × TNF-α were recognized as influencing factors for WCST scores. Our results suggest complex interactions between BDNF and cytokines were involved in the pathophysiology of executive function impairments in patients with SCZ.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Xiu MH,Wang DM,Du XD,Chen N,Tan SP,Tan YL,Yang F,Cho RY,Zhang XYdoi
10.1016/j.psyneuen.2019.06.006subject
Has Abstractpub_date
2019-10-01 00:00:00pages
110-117eissn
0306-4530issn
1873-3360pii
S0306-4530(19)30247-1journal_volume
108pub_type
杂志文章abstract：:Possible sex differences in the balance between dopaminergic and cholinergic activity in the rat striatum were investigated. Female rat show a greater vulnerability to neuroleptic-induced catalepsy compared to male rats. This vulnerability to neuroleptics has a human counterpart in that women show an increased frequen...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/0306-4530(83)90059-8
更新日期：1983-01-01 00:00:00
abstract：:Using percutaneously placed arterial and venous catheters, we examined the influence of aging on the plasma concentration, whole body production rate, and renal clearance of homovanillic acid (HVA) in 60 healthy adult volunteers. The arterio-renal fractional extraction of HVA combined with the renal plasma flow (Fick ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(94)90057-4
更新日期：1994-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2009.01.014
更新日期：2009-05-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(86)90032-6
更新日期：1986-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
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doi：10.1016/j.psyneuen.2008.08.008
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.06.020
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2000-02-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2006.07.004
更新日期：2006-10-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.104896
更新日期：2020-12-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/s0306-4530(00)00052-4
更新日期：2001-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.104593
更新日期：2020-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/0306-4530(82)90006-3
更新日期：1982-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2019.01.005
更新日期：2019-05-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.07.006
更新日期：2007-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.05.001
更新日期：2007-07-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2017.01.011
更新日期：2017-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(98)00023-7
更新日期：1998-07-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2010.03.003
更新日期：2010-10-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2014.12.021
更新日期：2015-03-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
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更新日期：2006-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.104386
更新日期：2019-11-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/s0306-4530(01)00036-1
更新日期：2002-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.11.009
更新日期：2016-02-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2008.06.002
更新日期：2008-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(95)00022-4
更新日期：1996-07-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.04.012
更新日期：2013-08-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2010.12.016
更新日期：2011-08-01 00:00:00
abstract：:Racial disparities in health outcomes between African Americans and European Americans have been well-documented, but not fully understood. Chronic inflammation contributes to several of the diseases showing racial disparities (e.g., Human Immunodeficiency Virus [HIV]), and racial differences in stress exposure (e.g.,...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.04.016
更新日期：2019-08-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2017.08.005
更新日期：2017-11-01 00:00:00
abstract：:The current study investigated the associations between thyroid stimulating hormone (TSH), free thyroxine (T(4)) and cognitive ability (general ability, memory and processing speed), in a large age homogenous sample (n=659) of generally healthy euthyroid older adults. Associations were considered both at baseline (mea...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.07.018
更新日期：2013-04-01 00:00:00
