Endocrinological and psychological responses to job stressors: an experimental test of the job demand--control model.

Abstract:

:The buffer hypothesis of the Job Demand-Control Model predicts that high levels of job control compensate for the negative effects of high job demands on well-being and health. Several studies have tested this hypothesis, but the results are far from consistent. The objective of this study was to test the buffer hypothesis with respect to psychological (subjective well-being) and physiological (salivary cortisol) indicators of job strain, using an experimental study design. Seventy-seven men and women worked at a simulated computer workplace for more than two hours. Job demands and job control were manipulated in a 2 (job demands: high vs. low)×2 (job control: high vs. low)×7 (time of measurement) study design. Demands were operationalized in terms of workload, and pacing control (self-paced vs. machine-paced) was used as a job control manipulation. As dependent variables, subjective well-being and salivary cortisol were measured at seven time points during the experiment (T1-T7). In line with the buffer hypothesis, high control eliminated the impact of high demands on salivary cortisol responses. The hypothesis was supported by a predicted significant three-way interaction of demands, control and time of measurement (p<.001), qualified by the absence of significant effects of the independent variables at T1 and T2 due to lagged cortisol reactions, and significant two-way interactions of demands and control, as predicted by the model, at the five remaining times of measurement (T3-T7): high demands led to increased cortisol reactions only in the low control condition. In contrast, no main or interaction effects of the independent variables were found for subjective well-being. This discrepancy between physiological and psychological stress reactions might be due to the lack of specificity inherent in measures of subjective well-being, due to lagged psychological reactions, or due to self-report biases in the subjective measures. In sum, this study provides the first clear-cut experimental evidence for the idea that the negative impact of high job demands on endocrinological responses can be buffered by high levels of job control.

journal_title

Psychoneuroendocrinology

authors

Häusser JA,Mojzisch A,Schulz-Hardt S

doi

10.1016/j.psyneuen.2010.12.016

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

1021-31

issue

7

eissn

0306-4530

issn

1873-3360

pii

S0306-4530(11)00004-7

journal_volume

36

pub_type

临床试验,杂志文章
  • Salivary cortisol and dehydroepiandrosterone sulfate in adolescent rape victims with post traumatic stress disorder.

    abstract:BACKGROUND:In chronic sexual abuse victims with post traumatic stress disorder (PTSD), the hypothalamic pituitary adrenal (HPA) axis can be dysregulated. In single rape victims, PTSD symptoms are hypothesized to function as a chronic stressor leading to similar HPA-axis dysregulation. The objective of the current study...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2012.06.015

    authors: Bicanic IA,Postma RM,Sinnema G,De Roos C,Olff M,Van Wesel F,Van de Putte EM

    更新日期:2013-03-01 00:00:00

  • Challenges for measuring oxytocin: The blind men and the elephant?

    abstract::Since its discovery more than a century ago, oxytocin has become one of the most intensively studied molecules in behavioral biology. In the last five years, Psychoneuroendocrinology has published more than 500 articles with oxytocin in the title, with many of these articles including measures of endogenous oxytocin c...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.psyneuen.2019.05.018

    authors: MacLean EL,Wilson SR,Martin WL,Davis JM,Nazarloo HP,Carter CS

    更新日期:2019-09-01 00:00:00

  • An oral presentation causes stress and memory impairments.

    abstract::Laboratory experiments revealed the stress hormone cortisol to decrease memory retrieval of emotional material, but a translation to real-life settings is missing so far. In this study, 51 students encoded a list of neutral, positive, and negative words as well as two neutral, biographical notes one day before attenda...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2019.02.010

    authors: Merz CJ,Hagedorn B,Wolf OT

    更新日期:2019-06-01 00:00:00

  • Repeatedly stressed rats have enhanced vulnerability to amygdala kindling epileptogenesis.

    abstract::Psychiatric disorders associated with elevated stress levels, such as depression, are present in many epilepsy patients, including those with mesial Temporal Lobe Epilepsy (mTLE). Evidence suggests that these psychiatric disorders can predate the onset of epilepsy, suggesting a causal/contributory role. Prolonged expo...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2012.06.005

    authors: Jones NC,Lee HE,Yang M,Rees SM,Morris MJ,O'Brien TJ,Salzberg MR

    更新日期:2013-02-01 00:00:00

  • Lithium, arginine vasopressin and the dex/CRH test in mood disordered patients.

    abstract::The impact of lithium on arginine vasopressin (AVP) release has implications for our understanding of the pathophysiology and treatment of mood disorders and for the interpretation of neuroendocrine studies. In this secondary analysis of neuroendocrine, data from 23 patients with chronic major depressive disorder, 41 ...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.psyneuen.2007.02.010

    authors: Watson S,Gallagher P,Smith MS,Young AH,Ferrier IN

    更新日期:2007-06-01 00:00:00

  • Impact of exogenous glucocorticoid use on salivary cortisol measurements among adults with asthma and rhinitis.

    abstract::The diurnal rhythm of cortisol secretion in chronic disease can reflect the interactions between exogenous and endogenous factors. Exogenous glucocorticoid use may impact salivary cortisol measurements, but this has not been well-studied in ambulatory settings. In this report salivary cortisol levels were used to eval...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.psyneuen.2005.03.003

    authors: Masharani U,Shiboski S,Eisner MD,Katz PP,Janson SL,Granger DA,Blanc PD

    更新日期:2005-09-01 00:00:00

  • Thyroid stimulating hormone, free thyroxine and cognitive ability in old age: the Lothian Birth Cohort Study 1936.

    abstract::The current study investigated the associations between thyroid stimulating hormone (TSH), free thyroxine (T(4)) and cognitive ability (general ability, memory and processing speed), in a large age homogenous sample (n=659) of generally healthy euthyroid older adults. Associations were considered both at baseline (mea...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2012.07.018

    authors: Booth T,Deary IJ,Starr JM

    更新日期:2013-04-01 00:00:00

  • Anticipatory sensitization to repeated stressors: the role of initial cortisol reactivity and meditation/emotion skills training.

    abstract::Anticipation may play a role in shaping biological reactions to repeated stressors-a common feature of modern life. We aimed to demonstrate that: (a) individuals who display a larger cortisol response to an initial stressor exhibit progressive anticipatory sensitization, showing progressively higher cortisol levels be...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2014.11.014

    authors: Turan B,Foltz C,Cavanagh JF,Wallace BA,Cullen M,Rosenberg EL,Jennings PA,Ekman P,Kemeny ME

    更新日期:2015-02-01 00:00:00

  • Peri-pubertal gonadotropin-releasing hormone agonist treatment affects sex biased gene expression of amygdala in sheep.

    abstract::The nature of hormonal involvement in pubertal brain development has attracted wide interest. Structural changes within the brain that occur during pubertal development appear mainly in regions closely linked with emotion, motivation and cognitive functions. Using a sheep model, we have previously shown that peri-pube...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2013.09.011

    authors: Nuruddin S,Krogenæs A,Brynildsrud OB,Verhaegen S,Evans NP,Robinson JE,Haraldsen IR,Ropstad E

    更新日期:2013-12-01 00:00:00

  • The effects of testosterone replacement on nocturnal penile tumescence and rigidity and erectile response to visual erotic stimuli in hypogonadal men.

    abstract::Nocturnal penile tumescence (NPT) and erectile response to visual erotic stimuli (VES) were measured, by means of a Rigiscan device, in nine hypogonadal men, and repeated after 3 months of androgen replacement. The same assessments were carried out once in 12 eugonadal controls. The number of satisfactory NPT response...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0306-4530(95)00017-8

    authors: Carani C,Granata AR,Bancroft J,Marrama P

    更新日期:1995-01-01 00:00:00

  • Psychological determinants of the cortisol stress response: the role of anticipatory cognitive appraisal.

    abstract::Psychosocial stress is a potent activator of the hypothalamus-pituitary-adrenal (HPA) axis. While the physiological mechanisms of HPA axis responses to stress as well as its short and long-term consequences have been extensively examined, less is known why someone elicits an acute neuroendocrine stress response, i.e. ...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.psyneuen.2005.02.001

    authors: Gaab J,Rohleder N,Nater UM,Ehlert U

    更新日期:2005-07-01 00:00:00

  • Assessing cortisol from hair samples in a large observational cohort: The Whitehall II study.

    abstract::Hair cortisol concentrations (HCC) have been suggested to reflect long-term integrated cortisol levels, but most evidence of associations with co-variates is from small samples of healthy volunteers. The objective of this study was to describe the collection of hair samples in a large cohort study and report associati...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2016.07.214

    authors: Abell JG,Stalder T,Ferrie JE,Shipley MJ,Kirschbaum C,Kivimäki M,Kumari M

    更新日期:2016-11-01 00:00:00

  • Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation.

    abstract:INTRODUCTION:The extraction of salient information from the environment is modulated by the activation of dopamine receptors. Using rodent models, we previously reported that gating deficits caused by dopamine receptor activation - as measured by the prepulse inhibition (PPI) of startle - are effectively opposed by inh...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2019.06.009

    authors: Mosher LJ,Cadeddu R,Yen S,Staudinger JL,Traccis F,Fowler SC,Maguire JL,Bortolato M

    更新日期:2019-10-01 00:00:00

  • Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone.

    abstract::Stress causes activation of the hypothalamic-pituitary-adrenal (HPA) axis and results in the secretion of corticosteroids, which facilitate behavioral adaptation and promote the termination of the stress response. These actions exerted by cortisol are mediated by two brain corticosteroid receptor types: the high affin...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.psyneuen.2009.07.006

    authors: van Leeuwen N,Kumsta R,Entringer S,de Kloet ER,Zitman FG,DeRijk RH,Wüst S

    更新日期:2010-04-01 00:00:00

  • Chronic stress differentially regulates glucocorticoid negative feedback response in rats.

    abstract::Exposure to chronic stress is thought to play an important role in the etiology of depression. In this disorder, a disrupted negative feedback response to exogenous glucocorticoids on cortisol secretion has been indicated. However, the regulation of glucocorticoid negative feedback by chronic stress is not fully under...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/s0306-4530(01)00004-x

    authors: Mizoguchi K,Yuzurihara M,Ishige A,Sasaki H,Chui DH,Tabira T

    更新日期:2001-07-01 00:00:00

  • Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells.

    abstract::The translocator protein 18 kDa (TSPO), initially characterized as peripheral benzodiazepine receptor, is a conserved outer mitochondrial membrane protein, implicated in cholesterol transport thereby affecting steroid hormone biosynthesis, as well as in general mitochondrial function related to bioenergetics, oxidativ...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2019.03.029

    authors: Bader S,Wolf L,Milenkovic VM,Gruber M,Nothdurfter C,Rupprecht R,Wetzel CH

    更新日期:2019-08-01 00:00:00

  • Preliminary evidence for obesity and elevations in fasting insulin mediating associations between cortisol awakening response and hippocampal volumes and frontal atrophy.

    abstract::Recent studies have demonstrated alterations in the cortisol awakening response (CAR) and brain abnormalities in adults with obesity and type 2 diabetes mellitus (T2DM). While adolescents with T2DM exhibit similar brain abnormalities, less is known about whether brain impairments and hypothalamic-pituitary-adrenal (HP...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2011.12.020

    authors: Ursache A,Wedin W,Tirsi A,Convit A

    更新日期:2012-08-01 00:00:00

  • Effects of combination treatment with mood stabilizers and mirtazapine on plasma concentrations of neuroactive steroids in depressed patients.

    abstract::Antidepressants such as SSRIs or mirtazapine have been demonstrated to increase the concentrations of 3alpha-reduced neuroactive steroids throughout several weeks of treatment. However, no data are available on the impact of mood stabilizers such as lithium or carbamazepine on neuroactive steroid levels in depressed p...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2007.04.004

    authors: Schüle C,Baghai TC,di Michele F,Eser D,Pasini A,Schwarz M,Rupprecht R,Romeo E

    更新日期:2007-07-01 00:00:00

  • The stress hormone cortisol blocks perceptual learning in humans.

    abstract::Cortisol, the primary glucocorticoid (GC) in humans, influences neuronal excitability and plasticity by acting on mineralocorticoid and glucocorticoid receptors. Cellular studies demonstrated that elevated GC levels affect neuronal plasticity, for example through a reduction of hippocampal long-term potentiation (LTP)...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2016.12.002

    authors: Dinse HR,Kattenstroth JC,Lenz M,Tegenthoff M,Wolf OT

    更新日期:2017-03-01 00:00:00

  • Effect of age, gender, menopausal status, and ovarian hormonal level on rTMS in treatment-resistant depression.

    abstract::This study examines how gender and menopausal status contribute to age effect on the antidepressant efficacy of repetitive transcranial stimulation (rTMS). Thirty-one women (17 premenopausal, 14 postmenopausal), and 16 men with treatment-refractory bipolar/major depression underwent 10 consecutive sessions of rTMS. Mo...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.psyneuen.2008.03.006

    authors: Huang CC,Wei IH,Chou YH,Su TP

    更新日期:2008-07-01 00:00:00

  • The effect of tryptophan on the cortisol response to social stress is modulated by the 5-HTTLPR genotype.

    abstract:OBJECTIVE:The S'/S' (S/S, S/Lg and Lg/Lg) variant of the serotonin (5-HT) transporter gene linked polymorphic region (5-HTTLPR) is associated with less efficient neurotransmission and may be more reactive to 5-HT manipulations. We tested the effects of l-tryptophan supplements on the cortisol response induced by a soci...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2012.05.016

    authors: Cerit H,Jans LA,Van der Does W

    更新日期:2013-02-01 00:00:00

  • Influence of stress on fear memory processes in an aversive differential conditioning paradigm in humans.

    abstract::It is widely assumed that learning and memory processes play an important role in the pathogenesis, expression, maintenance and therapy of anxiety disorders, such as phobias or post-traumatic stress disorder (PTSD). Memory retrieval is involved in symptom expression and maintenance of these disorders, while memory ext...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2012.12.018

    authors: Bentz D,Michael T,Wilhelm FH,Hartmann FR,Kunz S,von Rohr IR,de Quervain DJ

    更新日期:2013-07-01 00:00:00

  • Influence of subliminal intragastric fatty acid infusion on subjective and physiological responses to positive emotion induction in healthy women: A randomized trial.

    abstract:BACKGROUND:Subliminal intragastric fatty acid infusion attenuates subjective and brain responses to negative emotion induction. However, the underlying gut-brain signaling mechanisms remain unclear, and it is unknown whether such effect equally applies to positive emotion. OBJECTIVE:We aimed to investigate the interac...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2019.06.010

    authors: Zhao D,Boey L,Weltens N,Biesiekierski JR,Iven J,Depoortere I,Tack J,Van Oudenhove L

    更新日期:2019-10-01 00:00:00

  • Maternal prenatal anxiety and downregulation of placental 11β-HSD2.

    abstract:BACKGROUND:Raised maternal anxiety during pregnancy is associated with increased risk of adverse neurodevelopmental outcomes for her child. The mechanisms underlying this are not known but animal studies suggest prenatal stress may alter the function of the placenta. Here we determined whether maternal prenatal anxiety...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2011.09.014

    authors: O'Donnell KJ,Bugge Jensen A,Freeman L,Khalife N,O'Connor TG,Glover V

    更新日期:2012-06-01 00:00:00

  • Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease.

    abstract::Aging remains the main risk factor to suffer Alzheimer's disease (AD), though epidemiological studies also support that type 2 diabetes (T2D) is a major contributor. In order to explore the close relationship between both pathologies we have developed an animal model presenting both AD and T2D, by crossing APP/PS1 mic...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2015.07.606

    authors: Ramos-Rodriguez JJ,Jimenez-Palomares M,Murillo-Carretero MI,Infante-Garcia C,Berrocoso E,Hernandez-Pacho F,Lechuga-Sancho AM,Cozar-Castellano I,Garcia-Alloza M

    更新日期:2015-12-01 00:00:00

  • Neuroactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats.

    abstract::Depression is characterized by hypothalamo-pituitary-adrenocortical (HPA) axis hyperactivity. In this major mood disorder, neurosteroids and neurotrophins, particularly brain-derived neurotrophic factor (BDNF), seem to be implicated and have some antidepressant effects. BDNF is highly involved in regulation of the HPA...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2007.09.002

    authors: Naert G,Maurice T,Tapia-Arancibia L,Givalois L

    更新日期:2007-09-01 00:00:00

  • Intensifying sleep slow oscillations does not improve metabolic control in healthy men.

    abstract::Impaired sleep quality and sleep loss compromise glucose homeostasis and metabolic function, but the mechanisms linking sleep and metabolic health are largely unclear. In order to gain insight into the relevance of specific electrophysiological sleep characteristics for metabolic control, we assessed the acute effect ...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2018.08.028

    authors: Santiago JCP,Ngo HV,Jickeli C,Peter A,Hallschmid M

    更新日期:2019-01-01 00:00:00

  • Hair cortisol as a biomarker of stress and resilience in South African mixed ancestry females.

    abstract:BACKGROUND:Hair cortisol concentrations (HCC) are increasingly used as a biomarker of stress, however limited research exists regarding the relationship between HCC and protective factors, such as resilience. Additionally, studies measuring HCC need to account for possible confounders, and these factors have not been e...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2019.104543

    authors: van den Heuvel LL,Acker D,du Plessis S,Stalder T,Suliman S,Thorne MY,Kirschbaum C,Seedat S

    更新日期:2020-03-01 00:00:00

  • The role of the amygdala in human fear: automatic detection of threat.

    abstract::Behavioral data suggest that fear stimuli automatically activate fear and capture attention. This effect is likely to be mediated by a subcortical brain network centered on the amygdala. Consistent with this view, brain imaging studies show that masked facial stimuli activate the amygdala as do masked pictures of thre...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.psyneuen.2005.03.019

    authors: Ohman A

    更新日期:2005-11-01 00:00:00

  • Endogenous in-session cortisol during exposure therapy predicts symptom improvement: Preliminary results from a scopolamine-augmentation trial.

    abstract::The purpose of this study was to explore whether individual differences in glucocorticoid concentrations were associated with symptom improvement following exposure therapy for patients with social anxiety disorder. To do this, 60 participants with social anxiety disorder completed a randomized-controlled trial of exp...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2020.104657

    authors: Kuhlman KR,Treanor M,Imbriano G,Craske MG

    更新日期:2020-06-01 00:00:00