Abstract:
:The diurnal rhythm of cortisol secretion in chronic disease can reflect the interactions between exogenous and endogenous factors. Exogenous glucocorticoid use may impact salivary cortisol measurements, but this has not been well-studied in ambulatory settings. In this report salivary cortisol levels were used to evaluate aspects of the diurnal rhythm of cortisol secretion within an ambulatory population of patients with asthma and allergic rhinitis. 183 persons with asthma with or without concomitant rhinitis and 34 persons with rhinitis alone were asked to collect at home, two saliva samples, 30 min after awakening and 12h later. The salivary cortisol levels were quantified by enzyme immunoassay. The recent use of glucocorticoids in the study group was determined by interview and direct examination of medications. We report that the median salivary cortisol levels 30 min post-awakening significantly differed by exogenous steroid status: no glucocorticoid use (n = 91), 10.1 nmol/l; nasal gluco-corticoid use alone (n = 25), 11.4 nmol/l; inhaled glucocorticoids (with or without concomitant nasal glucocorticoids; n = 76), 9.0 nmol/l; systemic glucocorticoids (n = 17), 4.0 nmol/l; (P = 0.02). 12-h post-awakening salivary cortisol values among the groups were similar (P = 0.85). The median 30-min post-awakening cortisol differed significantly by type and amount of inhaled steroid used: non-fluticasone users (n = 21), 11.5 nmol/l; lower dose fluticasone (<800 microg per day, n = 35); 9.2 nmol/l; and higher dose fluticasone (> or =800 microg, n=20), 5 nmol/l; (P=0.01). We conclude that in an ambulatory setting, exogenous glucocorticoid use can decrease the 30 min post-awakening but not the 12-h post-awakening salivary cortisol levels, an effect that should be taken into account in assessing the effects of other potential determinants on cortisol secretion.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Masharani U,Shiboski S,Eisner MD,Katz PP,Janson SL,Granger DA,Blanc PDdoi
10.1016/j.psyneuen.2005.03.003keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
744-52issue
8eissn
0306-4530issn
1873-3360pii
S0306-4530(05)00050-8journal_volume
30pub_type
临床试验,杂志文章abstract::Married people tend to be healthier than both the previously (bereaved, divorced, and separated) and never married, but the mechanisms through which this occurs remain unclear. To this end, research has increasingly focused on how psychological stress experienced by unmarried versus married individuals may differentia...
journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.12.018
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.06.020
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/s0306-4530(01)00065-8
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.01.003
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.04.024
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,meta分析,评审
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-08-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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