Abstract:
:Dehydroepiandrosterone (DHEA) is a steroid that shows a marked age-related decline in humans. Previous research suggests potential for DHEA replacement in old age to enhance cognition and well-being. We conducted a clinical trial to test these hypotheses in a non-clinical sample of 46 men aged 62-76. Participants received either 50 mg DHEA daily for 13 weeks, followed by placebo for 13 weeks, or the reverse, in a randomised double-blind cross-over trial design. Levels of salivary cortisol and DHEA were measured at 0800 h and 2000 h prior to each assessment session. Cognition was assessed with tests of speed, attention and episodic memory. Well-being was measured with questionnaires of mood and perceived health. Mood questionnaires were completed at the assessment session as well as concurrently with saliva sampling.A correlational analysis of baseline behavioural data with hormonal data, controlling for age, revealed that higher morning DHEA was associated with lower confusion (r=-0.33; P=0.04), while higher evening DHEA was associated with lower anxiety (r=-0.35; P=0.03) and lower current negative mood in the morning (r=-0.37; P=0.03). Conversely, higher morning cortisol and a morning cortisol/DHEA ratio were associated with higher anxiety (r=0.35; P=0.03), (r=0.46; P=0.004), general mood disturbance (r=0.32; P=0.046), (r=0.32; P=0.04) and higher current negative mood in the evening (r=0.37; P=0.03), (r=0.38; P=0.03). A higher morning cortisol/DHEA ratio was also associated with higher confusion (r=0.39; P=0.01) and lower visuo-spatial memory performance (r=-0.39; P=0.01). Unexpectedly, higher evening cortisol was associated with faster choice reaction time (r=-0.33; P=0.04). These findings are consistent with an impairing effect of high cortisol on episodic memory and mood in older men, which may be attenuated by DHEA. When treatment effects were analysed, no significant effects of DHEA were observed on any of the trial outcomes, providing no support for benefits of DHEA supplementation for cognition or well-being in normal older men in the shorter-term.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
van Niekerk JK,Huppert FA,Herbert Jdoi
10.1016/s0306-4530(01)00014-2keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
591-612issue
6eissn
0306-4530issn
1873-3360pii
S0306-4530(01)00014-2journal_volume
26pub_type
临床试验,杂志文章,随机对照试验abstract::This study examined whether DHEA and its ratio to cortisol moderated risk for psychopathology among incarcerated youth exposed to childhood maltreatment. Resistance to stress-related psychopathology under adversity was also examined in relation to callous-unemotional (CU) traits, a personality construct characterized ...
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abstract::Many sex differences can be found in the expression of aggression and parental nurturing behaviors. It is important to determine if these are modulated by prenatal conditions. Here, using assisted reproduction technologies, we generated females that were (mixed-sex) or were not (same-sex) exposed to males during fetal...
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.09.019
更新日期:2013-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.12.020
更新日期:2012-08-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-02-01 00:00:00
abstract::To examine the role of alpha 2-adrenoceptors in the control of cortisol and ACTH, hormone responses to the selective alpha 2-antagonist idazoxan were studied in 12 normal volunteers. Plasma cortisol and ACTH were measured from 0930h-1230h on three occasions: before, on the 1st day, and on the 22nd day of an open treat...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(92)90066-g
更新日期:1992-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.09.038
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2010.05.011
更新日期:2010-11-01 00:00:00
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