Abstract：
:Distinct patterns of cortisol secretion have been associated with depression in past research, but it remains unclear whether individuals at-risk for depression may also have similar patterns of cortisol secretion. This is the first study to date of both naturalistic diurnal cortisol secretion and cortisol reactivity to a psychosocial laboratory stressor in depressed and at-risk adults. Cortisol secretion patterns were compared for 57 currently depressed, at-risk (based on trait-level positive and negative affect), and control participants over 5 days and in response to a laboratory stressor. After controlling for potentially confounding biobehavioral variables, the depressed group had a larger cortisol awakening response (CAR) and higher average diurnal cortisol compared to control participants. Individuals at-risk for depression also had significantly higher waking cortisol levels than control participants. Results for the psychosocial laboratory stressor did not show the predicted elevations in cortisol for depressed and at-risk participants compared to controls. The at-risk group recovered more quickly when compared to the depressed group both in levels of cortisol and concurrent measures of negative affect. The at-risk and depressed participants were similar on the diurnal cortisol measures, but differed on response to the laboratory social stressor, suggesting divergence in cortisol secretion patterns between currently depressed and temperamentally at-risk individuals. Further investigation of HPA functioning of individuals at-risk for depression may clarify the stress processes involved in risk for depression onset.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Dienes KA,Hazel NA,Hammen CLdoi
10.1016/j.psyneuen.2012.09.019subject
Has Abstractpub_date
2013-06-01 00:00:00pages
927-40issue
6eissn
0306-4530issn
1873-3360pii
S0306-4530(12)00335-6journal_volume
38pub_type
杂志文章abstract：:In this study, basal saliva cortisol was determined in women at 32 weeks of pregnancy and again at 9 months post-partum. During pregnancy, the cortisol levels of the 119 subjects were found to be elevated, with noon and evening levels more than twice as high as during the non-pregnant state. Despite the hypercortisoli...
journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,meta分析,评审
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pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2008.08.025
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type：
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更新日期：2004-07-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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更新日期：1992-08-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
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更新日期：2020-03-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
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更新日期：2001-10-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2007-06-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1996-05-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
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