Abstract:
:The neonatal nutritional environment is critical for programming the systems regulating body weight, and an inappropriate nutritional environment in early life can lead to overweight or obesity later on. In this study we demonstrate that changes to the neonatal nutritional environment, induced by changing the litter size in which the animal is raised, can alter not only body weight into adulthood, but also anxiety behaviours and stress responsiveness. These effects appear to be somewhat sex-dependent, affecting female rats more strongly than males. Thus, Wistar rats raised in small litters, where they have greater access to their mothers' milk, weigh more in adulthood than those raised in large litters. Females from these small litters show enhanced exploratory behaviour and reduced anxiety in the elevated plus maze, entering the open arms more often. They also display enhanced central responses to restraint stress including greater activation of the paraventricular nucleus of the hypothalamus and paraventricular nucleus of the thalamus, possibly indicating that the changes we see are related to enhanced arousal. Thus, while neonatal litter size affects long-term body weight regulation, it can also alter long-term activity, anxiety and stress responsiveness, and the degree to which it does so appears to be sex-dependent.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Spencer SJ,Tilbrook Adoi
10.1016/j.psyneuen.2009.02.013subject
Has Abstractpub_date
2009-09-01 00:00:00pages
1133-43issue
8eissn
0306-4530issn
1873-3360pii
S0306-4530(09)00067-5journal_volume
34pub_type
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.02.010
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(84)90008-8
更新日期:1984-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.05.029
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2008.06.002
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2017.08.005
更新日期:2017-11-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0306-4530(00)00031-7
更新日期:2001-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2017.01.009
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/j.psyneuen.2008.03.006
更新日期:2008-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.psyneuen.2013.01.002
更新日期:2013-09-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.02.008
更新日期:2011-09-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.11.007
更新日期:2019-03-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.104591
更新日期:2020-04-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.06.007
更新日期:2012-02-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2007.04.004
更新日期:2007-07-01 00:00:00