Abstract：
BACKGROUND:Our laboratory has previously reported that testosterone (T) administration to older men significantly improves cognitive function. This study examined potential changes in insulin-like growth factor (IGF) IGF-I, IGF-II and IGF-related binding proteins in response to T administration in older men and their relationship to cognitive functioning. METHODS:Twenty-five healthy community dwelling volunteers, ranging in age from 50-80 years were randomized to receive weekly intra-muscular (i.m.) injections of either 100 mg T enanthate or placebo (saline) for 6 weeks. Serum hormone levels and cognitive functioning was assessed at baseline and twice during treatment. RESULTS:Significant positive associations between IGF-I and IGF-II and spatial memory, spatial reasoning, and verbal fluency were observed after 6 weeks of T administration. Increased serum T levels from treatment were positively associated with improvement in spatial reasoning performance, whereas estradiol was associated with a decline in divided attention performance. Serum IGF-I, IGF-II and IGFBPs did not change in response to T treatment. CONCLUSIONS:Our results suggest that T, estradiol and IGF-I may have independent and selective effects on cognitive functioning. Positive associations between T levels and cognition are consistent with an effect of androgen treatment, whereas positive associations between IGF-I levels and cognition are reflective of a relationship between endogenous IGF-I levels and cognition.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Cherrier MM,Plymate S,Mohan S,Asthana S,Matsumoto AM,Bremner W,Peskind E,Raskind M,Latendresse S,Haley AP,Craft Sdoi
10.1016/s0306-4530(02)00136-1keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
65-82issue
1eissn
0306-4530issn
1873-3360pii
S0306453002001361journal_volume
29pub_type
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