Abstract:
:Among the studies of systemic hormonal and physiological abnormalities associated with anxiety disorders, the most consistent and extensive findings suggest (a) peripheral adrenergic hyperactivity (including increases in norepinephrine but not epinephrine) and functional dysregulation, (b) increased incidence of mitral valve prolapse in panic patients, and (c) normal suppressibility of the hypothalamic-pituitary-adrenal cortical endocrine system with dexamethasone in panic patients. Other less-certain findings include (a) increased circulating concentrations of plasma ACTH and/or cortisol, and prolactin, in panic patients, (b) increased platelet monoamine oxidase activity in generalized anxiety and/or panic patients, (c) decreased gonadal axis activity in some anxious individuals, (d) decreased nighttime melatonin plasma concentrations in panic patients, and (e) peripheral alpha 2 and beta-adrenoreceptor down-regulation, with normal serotonin binding parameters. These findings, taken together, provide tentative support for dysfunction in adrenergic and GABAergic central nervous system mechanisms in people with anxiety disorders. Abnormal anxiety and normal stress both show evidence of adrenergic hyperactivity; however, there appear to be differences in hormonal profiles, especially the apparent lack of increase of epinephrine during panic attacks, as well as differences in the reactivity of the system, and in the "trigger" mechanisms which determine when the response occurs.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Cameron OG,Nesse RMdoi
10.1016/0306-4530(88)90054-6subject
Has Abstractpub_date
1988-01-01 00:00:00pages
287-307issue
4eissn
0306-4530issn
1873-3360pii
0306-4530(88)90054-6journal_volume
13pub_type
杂志文章,评审abstract::Grief is conceptualized by strong negative emotions, which include longing, sadness, and preoccupations with thoughts, recollections, and images of the spouse. In the initial months after the loss of a spouse, those who are widowed are at risk for cardiovascular problems and premature mortality. In the general populat...
journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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更新日期:1992-08-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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更新日期:1998-11-01 00:00:00
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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更新日期:1986-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
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更新日期:2017-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/s0306-4530(98)00092-4
更新日期:1999-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2015.08.023
更新日期:2015-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Psychoneuroendocrinology
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2017.10.005
更新日期:2018-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.07.021
更新日期:2012-05-01 00:00:00
abstract::Testosterone concentrations rise rapidly in the context of competitive interactions and remain elevated in winners relative to losers. Theoretical models suggest that this divergent neuroendocrine response serves to mediate future dominance behaviours. Although research in animal models provides compelling support for...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
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更新日期:2013-10-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2007.10.007
更新日期:2008-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2008.10.019
更新日期:2009-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.02.025
更新日期:2016-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2005.09.003
更新日期:2006-04-01 00:00:00