Evidence for an association between an enhanced reactivity of interleukin-6 levels and reduced glucocorticoid sensitivity in patients with fibromyalgia.

Abstract:

:Pain and fatigue have been identified as core symptoms of fibromyalgia syndrome (FMS). Since both symptoms are also characteristic of hypocortisolemic disorders, reduced cortisol levels have been thought to promote an exacerbation of these FMS core symptoms by an enhanced reactivity of interleukin-6 (IL-6) levels. The aim of the current study was to investigate the pathophysiologic relevance of reduced cortisol levels for manifestation of FMS core symptoms. Twelve female FMS patients with 15 female controls were compared regarding the function of hypothalamus-pituitary-adrenal (HPA) axis and behavioral, endocrine and IL-6 responses after measuring the pressure pain thresholds (PPTs) at tender points. Function of HPA axis was assessed by determining the cortisol awakening response, daytime profile of cortisol secretion, low dose overnight dexamethasone suppression test (DST) and glucocorticoid sensitivity (GC) of inflammatory cytokine production. While endocrine and IL-6 responses were determined by collecting blood and saliva samples behavioral responses were assessed by pain and fatigue recordings of participants before and after PPT measurement using visual analogue scale (VAS). Whereas FMS patients were found not to differ from controls in cortisol awakening response, daytime profile of cortisol secretion and cortisol suppression after overnight DST, they did exhibit a reduced GC sensitivity of inflammatory cytokine production. PPT measurement did induce three times higher cortisol and four times higher IL-6 levels in FMS patients, but no change in their ACTH levels. The enhanced IL-6 reactivity after PPT measurement was accompanied by an increase in the severity of FMS patients' pain and fatigue ratings. The findings of the present study provide evidence for the pathophysiologic relevance of a disturbed glucocorticoid receptor (GR) function, rather than reduced cortisol levels for the maintenance of FMS core symptoms.

journal_title

Psychoneuroendocrinology

authors

Geiss A,Rohleder N,Anton F

doi

10.1016/j.psyneuen.2011.07.021

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

671-84

issue

5

eissn

0306-4530

issn

1873-3360

pii

S0306-4530(11)00263-0

journal_volume

37

pub_type

杂志文章
  • Testosterone responses to competition predict decreased trust ratings of emotionally neutral faces.

    abstract::A wealth of evidence has linked individual differences in testosterone (T) to social, cognitive, and behavioral processes related to human dominance. Moreover, recent evidence indicates that a single administration of T reduces interpersonal trust in healthy young women. Here, in a sample of men and women (n=96), we i...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2014.06.011

    authors: Carré JM,Baird-Rowe CD,Hariri AR

    更新日期:2014-11-01 00:00:00

  • Night sleep EEG and daytime sleep propensity in adult hypopituitary patients with growth hormone deficiency before and after six months of growth hormone replacement.

    abstract:BACKGROUND:Hypopituitary patients with growth hormone deficiency (GHD) complain of reduced vitality, general fatigue, lack of concentration, irritability and reduced alertness during daytime. It is unclear whether these symptoms are primarily due to GH-deficiency and/or secondary to GHD related sleep impairments. Bi-di...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2004.05.004

    authors: Schneider HJ,Oertel H,Murck H,Pollmächer T,Stalla GK,Steiger A

    更新日期:2005-01-01 00:00:00

  • Heightened HPA-axis stress reactivity and accelerated pubertal progression predicts depressive symptoms over 4-year follow up.

    abstract::Pubertal timing has been suggested as biological factors implicated in the onset of depression in girls. This study aims to examine the prospective association between accelerated pubertal progression with depressive symptoms, and to further explore the possible role of individual reactivity to social stress in this a...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2019.02.001

    authors: Gong C,Duan X,Su P,Wan Y,Xu Y,Tao F,Sun Y

    更新日期:2019-05-01 00:00:00

  • Hippocampal insulin resistance links maternal obesity with impaired neuronal plasticity in adult offspring.

    abstract:OBJECTIVE:Maternal obesity and a disturbed metabolic environment during pregnancy and lactation have been shown to result in many long-term health consequences for the offspring. Among them, impairments in neurocognitive development and performance belong to the most dreaded ones. So far, very few mechanistic approache...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2017.12.023

    authors: Schmitz L,Kuglin R,Bae-Gartz I,Janoschek R,Appel S,Mesaros A,Jakovcevski I,Vohlen C,Handwerk M,Ensenauer R,Dötsch J,Hucklenbruch-Rother E

    更新日期:2018-03-01 00:00:00

  • Latent trait cortisol (LTC) during pregnancy: Composition, continuity, change, and concomitants.

    abstract::Individual differences in the activity of the hypothalamic pituitary adrenal (HPA) axis are often operationalized using summary measures of cortisol that are taken to represent stable individual differences. Here we extend our understanding of a novel latent variable approach to latent trait cortisol (LTC) as a measur...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2015.08.009

    authors: Giesbrecht GF,Bryce CI,Letourneau N,Granger DA,APrON study Team.

    更新日期:2015-12-01 00:00:00

  • Hormonal markers of stress response following interruption of selective serotonin reuptake inhibitor treatment.

    abstract::Depressive illness is associated with loss of the usual regulation of stress-responsive hormonal and neurotransmitter systems, and antidepressants have intrinsic effects reducing the activity of these systems. Abrupt interruption of treatment with some antidepressants has been associated with a self-limited syndrome o...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0306-4530(99)00046-3

    authors: Michelson D,Amsterdam J,Apter J,Fava M,Londborg P,Tamura R,Pagh L

    更新日期:2000-02-01 00:00:00

  • Mouse females devoid of exposure to males during fetal development exhibit increased maternal behavior.

    abstract::Many sex differences can be found in the expression of aggression and parental nurturing behaviors. It is important to determine if these are modulated by prenatal conditions. Here, using assisted reproduction technologies, we generated females that were (mixed-sex) or were not (same-sex) exposed to males during fetal...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2011.07.009

    authors: Sugawara A,Pearson BL,Blanchard DC,Ward MA

    更新日期:2012-03-01 00:00:00

  • HPA axis activation by a socially evaluated cold-pressor test.

    abstract::The cold-pressor test (CPT) in which subjects immerse their hand in ice water is among the most commonly used laboratory stressors. While the CPT elicits strong sympathetic nervous system activation, cortisol elevations indicative for the reactivity of the hypothalamus-pituitary-adrenal (HPA) axis are moderate to low ...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2008.03.001

    authors: Schwabe L,Haddad L,Schachinger H

    更新日期:2008-07-01 00:00:00

  • A human chemosignal modulates frontolimbic activity and connectivity in response to emotional stimuli.

    abstract::Evidence suggests the putative human pheromone Δ4,16-androstadien-3-one (androstadienone), a natural component of human sweat, increases attention to emotional information when passively inhaled, even in minute amounts. However, the neural mechanisms underlying androstadienone's impact on the perception of emotional s...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2016.09.023

    authors: Hummer TA,Phan KL,Kern DW,McClintock MK

    更新日期:2017-01-01 00:00:00

  • Psychological determinants of the cortisol stress response: the role of anticipatory cognitive appraisal.

    abstract::Psychosocial stress is a potent activator of the hypothalamus-pituitary-adrenal (HPA) axis. While the physiological mechanisms of HPA axis responses to stress as well as its short and long-term consequences have been extensively examined, less is known why someone elicits an acute neuroendocrine stress response, i.e. ...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.psyneuen.2005.02.001

    authors: Gaab J,Rohleder N,Nater UM,Ehlert U

    更新日期:2005-07-01 00:00:00

  • Basal cortisol, cortisol reactivity, and telomere length: A systematic review and meta-analysis.

    abstract::The objective of the present study is to synthesize the existing empirical literature and perform a meta-analysis of published data on the relationship between cortisol and telomere length. We systematically searched studies that examined the relationship between cortisol and telomere length in humans on electronic da...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.psyneuen.2019.01.022

    authors: Jiang Y,Da W,Qiao S,Zhang Q,Li X,Ivey G,Zilioli S

    更新日期:2019-05-01 00:00:00

  • Prenatal testosterone exposure is associated with delay of gratification and attention problems/overactive behavior in 3-year-old boys.

    abstract::Sex differences in self-control become apparent during preschool years. Girls are better able to delay their gratification and show less attention problems and overactive behavior than boys. In this context, organizational effects of gonadal steroids affecting the neural circuitry underlying self-control could be resp...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2019.02.014

    authors: Körner LM,Pause BM,Meinlschmidt G,Tegethoff M,Fröhlich S,Kozlowski P,Rivet N,Jamey C,Reix N,Kintz P,Raul JS,Heil M

    更新日期:2019-06-01 00:00:00

  • Effect of codeine and oxazepam on afternoon cortisol secretion in men.

    abstract::The objective of this study was to investigate the effects of oral codeine and oxazepam on afternoon cortisol secretion. Nine subjects received either oxazepam (30 mg) or codeine (30 mg) or placebo at 1700h on separate days in a counterbalanced design; the subjects were not aware of the sequence. Blood samples were co...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0306-4530(89)90009-7

    authors: Garland EJ,Zis AP

    更新日期:1989-01-01 00:00:00

  • Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study.

    abstract::Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant w...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2017.02.012

    authors: Osborne LM,Gispen F,Sanyal A,Yenokyan G,Meilman S,Payne JL

    更新日期:2017-05-01 00:00:00

  • Mood changes and physical complaints during the normal menstrual cycle in healthy young women.

    abstract::Significant emotional and physical symptoms have been linked to hormonal changes during the menstrual cycle. A critical evaluation of the available studies questions the commonly held belief in menstrual-cycle-related complaints in the majority of normal women. The present study investigated changes in mood, somatic c...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/0306-4530(90)90021-z

    authors: Laessle RG,Tuschl RJ,Schweiger U,Pirke KM

    更新日期:1990-01-01 00:00:00

  • Suppression, but not reappraisal, is associated with inflammation in trauma-exposed veterans.

    abstract:BACKGROUND:Emotion dysregulation can elicit inflammatory activity. The current study examined whether specific maladaptive and adaptive emotion regulation strategies were associated with inflammatory markers in trauma-exposed veterans, above and beyond PTSD. METHODS:In a cohort study, 606 participants exposed to a Cri...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2020.104871

    authors: Khan AJ,O'Donovan A,Neylan TC,Gross JJ,Cohen BE

    更新日期:2020-12-01 00:00:00

  • Timing matters: Endogenous cortisol mediates benefits from early-day psychotherapy.

    abstract:OBJECTIVE:No simple way to augment fear extinction has been established. Cortisol has shown to enhance memory extinction and preliminary evidence suggest that extinction learning maybe more successful in the morning when cortisol is high. The aim was to determine whether exposure sessions conducted earlier in the day a...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2016.09.008

    authors: Meuret AE,Rosenfield D,Bhaskara L,Auchus R,Liberzon I,Ritz T,Abelson JL

    更新日期:2016-12-01 00:00:00

  • A 3-day estrogen treatment improves prefrontal cortex-dependent cognitive function in postmenopausal women.

    abstract::Estrogen secretion in young women follows a cyclic pattern characterized by a pronounced surge in estrogen around ovulation. The way in which this estrogen peak affects cognitive functioning is unclear. Short-term estrogen treatment for a few days mimicking normal pre-menopausal estrogen dynamics substantially enhance...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2006.05.007

    authors: Krug R,Born J,Rasch B

    更新日期:2006-09-01 00:00:00

  • The effects of two different doses of hydrocortisone on cognition in patients with secondary adrenal insufficiency--results from a randomized controlled trial.

    abstract:CONTEXT:A wide variety in hydrocortisone (HC) substitution dose-regimens are considered physiological for patients with secondary adrenal insufficiency (SAI). However, it is likely that cognition is negatively influenced by higher cortisol exposure to the brain. OBJECTIVE:To examine the effects of a high physiological...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2015.02.001

    authors: Werumeus Buning J,Brummelman P,Koerts J,Dullaart RP,van den Berg G,van der Klauw MM,Tucha O,Wolffenbuttel BH,van Beek AP

    更新日期:2015-05-01 00:00:00

  • Cultures under stress: A cross-national meta-analysis of cortisol responses to the Trier Social Stress Test and their association with anxiety-related value orientations and internalizing mental disorders.

    abstract::Acute cortisol changes are physiological indicators (i.e., biomarkers) of psychosocial stress that have been repeatedly assessed using standardized laboratory protocols like the Trier Social Stress Test (TSST). Despite this methodological standardization, however, cortisol stress responses vary considerably across dif...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.psyneuen.2018.12.236

    authors: Miller R,Kirschbaum C

    更新日期:2019-07-01 00:00:00

  • Hair cortisol concentrations in war-affected adolescents: A prospective intervention trial.

    abstract::Temporal examinations of the biological signature of stress or trauma in war-affected populations are seldom undertaken. Moreover, few studies have examined whether stress biomarkers track biological sensitivity to brief interventions targeting the improvement of psychosocial wellbeing. Our study is the first to prosp...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2017.12.012

    authors: Dajani R,Hadfield K,van Uum S,Greff M,Panter-Brick C

    更新日期:2018-03-01 00:00:00

  • Longitudinal hypothalamic-pituitary-adrenal axis trait and state effects in recurrent depression.

    abstract:BACKGROUND:Hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity has been observed in (recurrent) major depressive disorder (MDD), although inconsistently and mainly cross-sectional. Longitudinal studies clarifying state-trait issues are lacking. We aimed to determine whether HPA-axis (hyper)activity in recurrent MDD...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2011.10.005

    authors: Lok A,Mocking RJ,Ruhé HG,Visser I,Koeter MW,Assies J,Bockting CL,Olff M,Schene AH

    更新日期:2012-07-01 00:00:00

  • Maternal serum concentrations of BDNF and depression in the perinatal period.

    abstract::There is accumulating evidence that a deficiency in brain-derived neurotrophic factor (BDNF) plays a critical role in the pathophysiology of depression. This is in line with the postulate that low BDNF levels in serum are associated with depression. However, the regulation of maternal BDNF serum levels in the perinata...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2005.09.003

    authors: Lommatzsch M,Hornych K,Zingler C,Schuff-Werner P,Höppner J,Virchow JC

    更新日期:2006-04-01 00:00:00

  • Discrimination exposure and DNA methylation of stress-related genes in Latina mothers.

    abstract::Latina mothers, who have the highest fertility rate among all ethnic groups in the US, are often exposed to discrimination. The epigenetic changes related to this discrimination are largely unknown. This study is the first to explore the relationship between discrimination and DNA methylation of stress regulatory gene...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2018.08.014

    authors: Santos HP Jr,Nephew BC,Bhattacharya A,Tan X,Smith L,Alyamani RAS,Martin EM,Perreira K,Fry RC,Murgatroyd C

    更新日期:2018-12-01 00:00:00

  • Helpless behavior (escape deficits) in streptozotocin-diabetic rats: resistance to antidepressant drugs.

    abstract::Using the learned helplessness model of depression in rats, the present study undertook to investigate the possibility of an impaired response to antidepressant drugs in diabetic animals. Experimental diabetes was induced by three intraperitoneal (IP) injections of streptozotocin (37.5, 37.5, 50 mg/kg, three days apar...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/0306-4530(89)90064-4

    authors: Massol J,Martin P,Belon JP,Puech AJ,Soubrié P

    更新日期:1989-01-01 00:00:00

  • Exposure to stress attenuates fear retrieval in healthy men.

    abstract::The stress hormone cortisol reduces retrieval of emotional memories, which has been suggested to support the treatment of psychiatric disorders characterized by exaggerated fear-related memories. Indeed, studies in patients with anxiety disorders have indicated that the success of exposure therapy can be enhanced with...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2013.12.009

    authors: Merz CJ,Hamacher-Dang TC,Wolf OT

    更新日期:2014-03-01 00:00:00

  • Endocrinological and psychological responses to job stressors: an experimental test of the job demand--control model.

    abstract::The buffer hypothesis of the Job Demand-Control Model predicts that high levels of job control compensate for the negative effects of high job demands on well-being and health. Several studies have tested this hypothesis, but the results are far from consistent. The objective of this study was to test the buffer hypot...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.psyneuen.2010.12.016

    authors: Häusser JA,Mojzisch A,Schulz-Hardt S

    更新日期:2011-08-01 00:00:00

  • Processing of food stimuli is selectively enhanced during insulin-induced hypoglycemia in healthy men.

    abstract::Recently it has been reported that during insulin-induced hypoglycemia selective attention is directed to food stimuli suggesting an adaptive cognitive strategy to escape from this potentially dangerous metabolic state. Here, we tested this hypothesis using a short-term memory task. We also aimed to define a hypoglyce...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.psyneuen.2004.12.006

    authors: Schultes B,Peters A,Kern W,Gais S,Oltmanns KM,Fehm HL,Born J

    更新日期:2005-06-01 00:00:00

  • Gender differences in corticotropin and corticosterone secretion and corticotropin-releasing factor mRNA expression in the paraventricular nucleus of the hypothalamus and the central nucleus of the amygdala in response to footshock stress or psychological

    abstract::Anorexia nervosa is mostly seen in adolescent females, although the gender-differentiation mechanism is unclear. Corticotropin-releasing factor (CRF), a key peptide for stress responses such as inhibition of food intake, increases in arousal and locomotor activity, and gonadal dysfunction, is thought to be involved in...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2008.09.003

    authors: Iwasaki-Sekino A,Mano-Otagiri A,Ohata H,Yamauchi N,Shibasaki T

    更新日期:2009-02-01 00:00:00

  • Systemic hormonal and physiological abnormalities in anxiety disorders.

    abstract::Among the studies of systemic hormonal and physiological abnormalities associated with anxiety disorders, the most consistent and extensive findings suggest (a) peripheral adrenergic hyperactivity (including increases in norepinephrine but not epinephrine) and functional dysregulation, (b) increased incidence of mitra...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/0306-4530(88)90054-6

    authors: Cameron OG,Nesse RM

    更新日期:1988-01-01 00:00:00