Abstract：
:Estrogen-induced synaptic plasticity was frequently shown by an increase of spines at apical dendrites of CA1 pyramidal neurons after systemic application of estradiol to ovariectomized rats. Surprisingly, exogenous application of estradiol to hippocampal cultures had no effect on spines and on spine synapses, although quantitative immunohistochemistry revealed an upregulation of spinophilin and of synaptophysin, in these cultures. The role of synaptophysin as a presynaptic marker and of spinophilin as a postsynaptic marker, appears questionable from these discrepancies. In contrast, synaptopodin, a marker protein of "mature" mushroom-shaped spines, was downregulated after treatment of hippocampal cultures with estradiol. Synaptopodin is strongly associated to the spine apparatus, a spine-specific cell organelle, which is present in 80% of all mushroom-shaped spines. Consistently, we found a reduction in the number of spines, containing a spine apparatus in response to estradiol, suggesting that the presence of a spine apparatus in many but not all spines is very likely a result of their dynamic character. In summary, synaptic proteins appear to be regulated by estradiol, independent of its function on spine and spine synapse formation.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Fester L,Zhou L,Voets C,Ossig C,Disteldorf E,Bläute F,Prange-Kiel J,Dudzinski D,Jarry H,Rune GMdoi
10.1016/j.psyneuen.2009.08.013subject
Has Abstractpub_date
2009-12-01 00:00:00pages
S123-9eissn
0306-4530issn
1873-3360pii
S0306-4530(09)00259-5journal_volume
34 Suppl 1pub_type
杂志文章,评审abstract：:It is widely assumed that learning and memory processes play an important role in the pathogenesis, expression, maintenance and therapy of anxiety disorders, such as phobias or post-traumatic stress disorder (PTSD). Memory retrieval is involved in symptom expression and maintenance of these disorders, while memory ext...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.12.018
更新日期：2013-07-01 00:00:00
abstract：:Corticosteroids from the adrenal cortex influence a variety of behaviours including cognition, learning and memory. These hormones act via two intracellular receptors, the mineralo-corticoid receptor (MR) and the glucocorticoid receptor (GR). These two receptor types display a high concentration and distinct distribut...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(97)00091-7
更新日期：1998-01-01 00:00:00
abstract：:Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant w...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2017.02.012
更新日期：2017-05-01 00:00:00
abstract：:Understanding maternal mental health and cortisol regulation across pregnancy and the relationship to the development of the offspring's stress regulation is critical to a range of health outcomes. The aim of this study was to investigate infant and maternal cortisol in women with depression. Data were obtained from 2...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.104374
更新日期：2019-11-01 00:00:00
abstract：:Early life stress is one of the best characterized risk factors for psychiatric disorders, including depression, and many animal models have therefore studied the long-term physiological and behavioural consequences of early life stress. In most approaches a very deterministic view of adverse experiences early in life...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2010.07.001
更新日期：2011-04-01 00:00:00
abstract：:During the menopause transition, women are at increased risk of subjective symptoms of executive dysfunction. Evidence from animal and human participant studies suggests adverse childhood experiences (ACE) may be a risk factor for executive complaints during this hormonal transition. Preclinical literature indicates e...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2017.07.239
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Despite availability of effective trauma-focused psychotherapies, treatment non-response in youth with (partial) posttraumatic stress disorder remains substantial. Studies in adult PTSD have suggested that cortisol is associated with treatment outcome. Furthermore, cortisol prior to treatment could be used t...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.104380
更新日期：2019-11-01 00:00:00
abstract：:Since its discovery more than a century ago, oxytocin has become one of the most intensively studied molecules in behavioral biology. In the last five years, Psychoneuroendocrinology has published more than 500 articles with oxytocin in the title, with many of these articles including measures of endogenous oxytocin c...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2019.05.018
更新日期：2019-09-01 00:00:00
abstract：:The role of corticosteroids in brain aging remains a controversial issue. Conceivably, if corticosteroids levels are increased in the aged brain, neuronal function might be altered. For instance, GABA-mediated synaptic events, spike accommodation and afterhyperpolarizing potentials (AHPs) might be modified. Our electr...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(97)00008-5
更新日期：1997-01-01 00:00:00
abstract：:Changes in blood pressure (BP), plasma norepinephrine (NE), serum prolactin (PRL), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) associated with infusions of two thyrotropin-releasing hormone (TRH) doses (0.1 mg, 0.5 mg) were examined in 10 men with early-onset Alzheimer's disease (AD) and nine norm...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(89)90033-4
更新日期：1989-01-01 00:00:00
abstract：:Early life events have special importance in the development as postnatal environmental alterations may permanently affect the lifetime vulnerability to diseases. For the interpretation of the long-term consequences it is important to understand the immediate effects. As the role of vasopressin in hypothalamic-pituita...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2014.10.018
更新日期：2015-01-01 00:00:00
abstract：:In addition to its classical role in mediating responses to pain, the opioid system is strongly implicated in the regulation of social behavior. In young laboratory animals, low doses of opioid analgesic drugs reduce responses to isolation distress and increase play behavior. However, little is known about how opioid ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.09.011
更新日期：2016-01-01 00:00:00
abstract：:Intravenous injections of CCK-B agonists, such as pentagastrin, produce symptoms of panic and potent activation of the human hypothalamic-pituitary-adrenal (HPA) axis. It is unclear whether these psychological and endocrine effects are mediated by similar or independent processes. Independence is supported by prior ev...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2004.01.009
更新日期：2004-10-01 00:00:00
abstract：:The present study examined stressor interactions with genotype and light/dark cycle. Male Brown Norway (BN), Fischer 344 (F344), Lewis (from two different vendors: Lew/CR and Lew/H) and Sprague Dawley (SD) rats were exposed to footshock either in the early light or early dark circadian phase. Immediately after footsho...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(95)00009-7
更新日期：1995-01-01 00:00:00
abstract：:Multiple lines of evidence indicate that patients with chronic schizophrenia (SCZ) display executive dysfunction across the illness course. However, the potential molecular pathophysiologic mechanisms remain poorly elucidated. Neurodevelopmental changes caused by alterations of inflammatory mediators and neurotrophins...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.06.006
更新日期：2019-10-01 00:00:00
abstract：:Retinal projections to several telencephalic structures have been demonstrated in a wide range of mammalian species following intraocular injections of tritiated amino acids and cholera toxin subunit-B conjugated to horseradish peroxidase. Since these regions are also innervated by olfactory fibers, we investigated th...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(94)90046-9
更新日期：1994-01-01 00:00:00
abstract：:The relationship between stress and changes in insulin levels, plasma ratio of tryptophan to other large neutral amino acids (LNAAs), mood, and food intake was investigated in women taking monophasic oral contraceptives containing progestagens. Subjects experiencing high levels of stress displayed significant decrease...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/0306-4530(94)00063-g
更新日期：1995-01-01 00:00:00
abstract：:Although a majority of people will be exposed to a traumatic event over the course of their lifespan, only a minority will develop post-traumatic stress disorder. Better understanding the factors contributing to the development of this psychopathology is of high importance and could significantly reduce the societal a...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.03.006
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:The hypothalamic-pituitary-adrenal (HPA) axis is a critical mediator linking stress to health. Understanding how to modulate its reactivity could potentially help reduce the detrimental health effects of HPA axis activation. Social evaluative threat is a potent activator of this system. Access to control and...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2014.02.016
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:The S'/S' (S/S, S/Lg and Lg/Lg) variant of the serotonin (5-HT) transporter gene linked polymorphic region (5-HTTLPR) is associated with less efficient neurotransmission and may be more reactive to 5-HT manipulations. We tested the effects of l-tryptophan supplements on the cortisol response induced by a soci...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2012.05.016
更新日期：2013-02-01 00:00:00
abstract：:In this study, basal saliva cortisol was determined in women at 32 weeks of pregnancy and again at 9 months post-partum. During pregnancy, the cortisol levels of the 119 subjects were found to be elevated, with noon and evening levels more than twice as high as during the non-pregnant state. Despite the hypercortisoli...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2005.05.003
更新日期：2005-10-01 00:00:00
abstract：:Depressive illness is associated with loss of the usual regulation of stress-responsive hormonal and neurotransmitter systems, and antidepressants have intrinsic effects reducing the activity of these systems. Abrupt interruption of treatment with some antidepressants has been associated with a self-limited syndrome o...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0306-4530(99)00046-3
更新日期：2000-02-01 00:00:00
abstract：:Menstrual synchrony has been typically studied among women who live together: dormitory roommates or family members sharing a bedroom or living in the same house. The current study examined menstrual synchrony in 51 pairs of women working together under conditions optimally conducive to synchrony. They had been togeth...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(98)00092-4
更新日期：1999-05-01 00:00:00
abstract：:It is generally established that active-coping strategies and greater perceived control over pain are associated with improved pain-related outcomes; however, it remains unclear whether these factors independently or interactively influence adrenocortical function in reaction to a painful stimulus. The present study e...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2009.12.003
更新日期：2010-07-01 00:00:00
abstract：:In many species testosterone fluctuates in concert with outcome-dependent changes in social status, such that winning a competition leads to an increase in circulating testosterone (i.e., competition effect). Although this phenomenon has been well studied in humans, the cumulative endocrine impact of multiple successi...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2014.05.001
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Previous studies have examined whether steroid hormone treatment in transgender individuals may affect cognitive function; yet, their limited power does not allow firm conclusions to be drawn. We leveraged data from to-date literature aiming to explore the effect of gender-affirming hormone administration on...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2020.104721
更新日期：2020-09-01 00:00:00
abstract：:In the female rat, stimulation of the uterine cervix (CS) during mating or by artificial means induces daily diurnal and nocturnal surges in prolactin (PRL) secretion which, in the absence of fertilization, result in an 12-day anestrous period called pseudopregnancy (PSP). The amount or type of mating stimulation rece...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(94)90016-7
更新日期：1994-01-01 00:00:00
abstract：:Recently it has been reported that during insulin-induced hypoglycemia selective attention is directed to food stimuli suggesting an adaptive cognitive strategy to escape from this potentially dangerous metabolic state. Here, we tested this hypothesis using a short-term memory task. We also aimed to define a hypoglyce...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2004.12.006
更新日期：2005-06-01 00:00:00
abstract：:Pubertal timing has been suggested as biological factors implicated in the onset of depression in girls. This study aims to examine the prospective association between accelerated pubertal progression with depressive symptoms, and to further explore the possible role of individual reactivity to social stress in this a...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.02.001
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:Several studies have established links between thyroid gland dysfunction and mood disorders, in particular major depressive disorder (MDD). Preliminary evidence also suggests that thyroid hormone gene variants influence grey matter (GM) volume, which is reportedly altered in patients with MDD. This study test...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2010.12.002
更新日期：2011-07-01 00:00:00
