Abstract：
:Early life events have special importance in the development as postnatal environmental alterations may permanently affect the lifetime vulnerability to diseases. For the interpretation of the long-term consequences it is important to understand the immediate effects. As the role of vasopressin in hypothalamic-pituitary-adrenal axis regulation as well as in affective disorders seem to be important we addressed the question whether the congenital lack of vasopressin will modify the stress reactivity of the pups and will influence the later consequences of single 24h maternal deprivation (MD) on both stress-reactivity and stress-related behavioral changes. Vasopressin-producing (di/+) and deficient (di/di) Brattleboro rat were used. In 10-day-old pups MD induced a remarkable corticosterone rise in both genotypes without adrenocorticotropin (ACTH) increase in di/di rats. Studying the later consequences at around weaning (25-35-day-old rats) we found somatic and hormonal alterations (body weight reduction, dysregulation of the stress axis) which were not that obvious in di/di rats. The more anxious state of MD rats was not detectable in di/di rats both at weaning and in adulthood (7-12-week-old). The lack of vasopressin abolished all chronic stress and anxiety-like tendencies both at weaning and in adulthood probably as a consequence of reduced ACTH rise immediately after MD in pups. This finding suggests that postnatal stress-induced ACTH rise may have long-term developmental consequences.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Zelena D,Stocker B,Barna I,Tóth ZE,Makara GBdoi
10.1016/j.psyneuen.2014.10.018subject
Has Abstractpub_date
2015-01-01 00:00:00pages
378-91eissn
0306-4530issn
1873-3360pii
S0306-4530(14)00402-8journal_volume
51pub_type
杂志文章abstract：BACKGROUND:The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with de...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2010.09.009
更新日期：2011-06-01 00:00:00
abstract：:The incidence of chronic stress is frequently related to the development of psychiatric disorders like depression. The hypothalamic-pituitary-adrenal (HPA) axis is a major physiological system that mediates the stress response. Tight HPA axis regulation through negative feedback mechanisms is essential for health and ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2010.09.007
更新日期：2011-05-01 00:00:00
abstract：:The reliability of serum glucose concentrations as an index of habituation to chronic stress was evaluated in adult male rats. The glucose response to immobilization was attenuated by six days of previous chronic exposure to the same stressor, the degree of reduction being related to the duration (15 min, 1 hr or 4 hr...
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doi：10.1016/0306-4530(90)90059-i
更新日期：1990-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0306-4530(95)00058-5
更新日期：1996-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2011.12.020
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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更新日期：2011-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.09.003
更新日期：2007-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.02.004
更新日期：2013-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.104791
更新日期：2020-10-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/0306-4530(91)90079-9
更新日期：1991-01-01 00:00:00
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pub_type： 临床试验,杂志文章
doi：10.1016/0306-4530(93)90037-l
更新日期：1993-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2010.06.011
更新日期：2011-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2010.09.012
更新日期：2011-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2009.10.019
更新日期：2010-07-01 00:00:00
abstract：:Repeated exposure to homotypic laboratory psychosocial stressors typically instigates rapid habituation in hypothalamic-pituitary-adrenal (HPA) axis-mediated stress responses in humans. However, emerging evidence suggests the combination of physical stress and social evaluative threat may be sufficient to attenuate th...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.09.025
更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0306-4530(00)00033-0
更新日期：2001-02-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine if children with fragile X syndrome, who typically demonstrate a neurobehavioral phenotype that includes social anxiety, withdrawal, and hyper-arousal, have increased levels of cortisol, a hormone associated with stress. The relevance of adrenocortical activity to th...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(01)00087-7
更新日期：2002-10-01 00:00:00
abstract：:Low cortisol levels have been observed in patients with different stress-related disorders such as chronic fatigue syndrome, fibromyalgia, and post-traumatic stress disorder. Data suggest that these disorders are characterized by a symptom triad of enhanced stress sensitivity, pain, and fatigue. This overview will pre...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2005.04.006
更新日期：2005-11-01 00:00:00
abstract：:Prenatal exposure to testosterone has been shown to affect fetal brain maturation as well as postnatal cognition and behavior in animal studies. Although there are well-established sex-differences in the use of social communication (or 'pragmatic language') in humans, there has been limited investigation of the associ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2010.02.007
更新日期：2010-09-01 00:00:00
abstract：:The diurnal rhythm of cortisol secretion in chronic disease can reflect the interactions between exogenous and endogenous factors. Exogenous glucocorticoid use may impact salivary cortisol measurements, but this has not been well-studied in ambulatory settings. In this report salivary cortisol levels were used to eval...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2005.03.003
更新日期：2005-09-01 00:00:00
abstract：:Circulating cortisol levels are known to influence explicit memory in humans and other primates. The present study investigated salivary cortisol and its association with explicit memory performance in 99 postmenopausal women (64 treated with conjugated equine estrogens or estradiol, and 35 matched controls not using ...
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.11.009
更新日期：2016-02-01 00:00:00
abstract：:In mothers, offspring cues are associated with a powerful reinforcing value that motivates maternal care. Animal studies show that this is mediated by dopamine release into the nucleus accumbens, a core component of the brain's reward system located in the ventral striatum (VStr). The VStr is also known to respond to ...
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.104507
更新日期：2020-02-01 00:00:00
abstract：:Menstrually related symptoms and disorders are multidimensional and affect diverse physiologic systems. Elucidation of the pathophysiologic mechanisms of these disorders should allow for a more precise diagnosis, and provide direction for targeted therapeutic interventions. Several biologic mechanisms that underlie me...
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pub_type： 杂志文章,评审
doi：10.1016/s0306-4530(03)00097-0
更新日期：2003-08-01 00:00:00
abstract：:Cognitive decline in old age is not universal or inevitable. Associations have been observed with neuroendocrine function, but the relevance of other physiological processes is unclear. We predicted that impairment of memory in an ageing population would be related to the dysregulation of neuroendocrine and cardiovasc...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2005.04.001
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Delay discounting as a measure of impulsivity has been shown to be higher in obesity with an association of increased food intake. Moreover, obese humans showed a higher wanting for high-calorie food than lean men when blood glucose concentrations were low. First studies linking blood glucose levels to delay...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2018.01.014
更新日期：2018-03-01 00:00:00
