Suppression of lymphocyte mitogenesis in different rat strains exposed to footshock during early diurnal and nocturnal time periods.

Abstract:

:The present study examined stressor interactions with genotype and light/dark cycle. Male Brown Norway (BN), Fischer 344 (F344), Lewis (from two different vendors: Lew/CR and Lew/H) and Sprague Dawley (SD) rats were exposed to footshock either in the early light or early dark circadian phase. Immediately after footshock, the spleen and whole blood proliferation to PHA and Con A was assessed. To provide endocrine indices of stress, serum was measured for corticosterone and interleukin-6 (IL-6). All rats showed significant increases in serum corticosterone and IL-6 following footshock either in the light or the dark. Rat strain differences were noted in the IL-6 response, while the corticosterone response was strong for all strains. The criterion for 'suppression' of lymphocyte proliferation was p < .05 (as determined by ANOVA) compared to non-shocked controls. Spleen: with the exception of BN rats, the other strains showed suppressed spleen cell proliferation to PHA and Con A both in the light and the dark. BN rats failed to show suppression of mitogenic activity to PHA when footshock was given in the light. Peripheral blood lymphocytes: suppression in Lew rats from either vendor, and in F344 and BN rats, did not vary with time of day nor with the type of mitogen tested. SD rats did not show suppression to PHA if shocked in the light. These results highlight the generality of stressor-induced mitogenic lymphocyte proliferation during the early diurnal and nocturnal periods of the day.

journal_title

Psychoneuroendocrinology

authors

Kusnecov AW,Shurin MR,Armfield A,Litz J,Wood P,Zhou D,Rabin BS

doi

10.1016/0306-4530(95)00009-7

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

821-35

issue

8

eissn

0306-4530

issn

1873-3360

pii

0306453095000097

journal_volume

20

pub_type

杂志文章
  • Pregnancy, the postpartum, and steroid hormones: effects on cognition and mood.

    abstract::The effects of pregnancy on cognition and mood were examined using a repeated-measures design. Nineteen women, average age 33, were tested with a comprehensive neuropsychological battery during their last 2 months of pregnancy and again within 2 months of delivery. Blood samples were obtained from all subjects and ass...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/s0306-4530(98)00044-4

    authors: Buckwalter JG,Stanczyk FZ,McCleary CA,Bluestein BW,Buckwalter DK,Rankin KP,Chang L,Goodwin TM

    更新日期:1999-01-01 00:00:00

  • Oxytocin receptor gene rs53576 polymorphism modulates oxytocin-dopamine interaction and neuroticism traits--a SPECT study.

    abstract::Brain oxytocin and dopamine systems interact to modulate social cognitive behavior. Whether the interactions are modulated by oxytocin receptor (OXTR) gene variations remains unclear. Considering the dopamine transporter (DAT) availability as an endophenotype and the degree of dopamine-mediated neuroticism as a phenot...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2014.05.020

    authors: Chang WH,Lee IH,Chen KC,Chi MH,Chiu NT,Yao WJ,Lu RB,Yang YK,Chen PS

    更新日期:2014-09-01 00:00:00

  • Latent trait cortisol (LTC) during pregnancy: Composition, continuity, change, and concomitants.

    abstract::Individual differences in the activity of the hypothalamic pituitary adrenal (HPA) axis are often operationalized using summary measures of cortisol that are taken to represent stable individual differences. Here we extend our understanding of a novel latent variable approach to latent trait cortisol (LTC) as a measur...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2015.08.009

    authors: Giesbrecht GF,Bryce CI,Letourneau N,Granger DA,APrON study Team.

    更新日期:2015-12-01 00:00:00

  • Elevating the perspective on human stress genomics.

    abstract::Functional genomics strategies have been slow to penetrate research on human stress and coping, but recent conceptual advances have yielded a raft of new findings relating social and psychological conditions to broad alterations in human gene expression. This article reviews the field of human stress genomics, analyze...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.psyneuen.2010.06.008

    authors: Cole SW

    更新日期:2010-08-01 00:00:00

  • Impaired hormonal regulation of appetite in schizophrenia: A narrative review dissecting intrinsic mechanisms and the effects of antipsychotics.

    abstract::Cardiometabolic diseases are the main contributor of reduced life expectancy in patients with schizophrenia. It is now widely accepted that antipsychotic treatment plays an important role in the development of obesity and its consequences. However, some intrinsic mechanisms need to be taken into consideration. One of ...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.psyneuen.2020.104744

    authors: Lis M,Stańczykiewicz B,Liśkiewicz P,Misiak B

    更新日期:2020-09-01 00:00:00

  • Absence of a normal cortisol awakening response (CAR) in adolescent males with Asperger syndrome (AS).

    abstract::In addition to abnormalities in social and communication development, a 'need for sameness' and 'resistance to change' are features of autistic spectrum disorders first identified by Kanner in 1943. Our ability to react to change is modulated by the hypothalamic-pituitary-adrenal (HPA) axis, a feature of which is a dr...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2009.02.011

    authors: Brosnan M,Turner-Cobb J,Munro-Naan Z,Jessop D

    更新日期:2009-08-01 00:00:00

  • Changes in gonadotropin regulation in both behavioral and phenotypic disturbances of sexual differentiation in men.

    abstract::Determinations of gonadotropins and testosterone were performed in 22 men with hypospadias (H), seven male-to-female transsexuals (T) and in 16 normal men (N), all of similar age. The response of serum FSH and LH to GnRH was determined in six subjects in each group. Oligospermia was found in five of 13 patients with H...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/0306-4530(86)90032-6

    authors: Kula K

    更新日期:1986-01-01 00:00:00

  • A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania.

    abstract::Emerging research has suggested that hormone treatments such as selective oestrogen receptor modulators (SERMs) or progestins may be useful in the treatment of mania. The current pilot study compared the use of the SERM tamoxifen and the progestin medroxyprogesterone acetate (MPA), as an adjunct to mood stabiliser med...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2014.02.004

    authors: Kulkarni J,Berk M,Wang W,Mu L,Scarr E,Van Rheenen TE,Worsley R,Gurvich C,Gavrilidis E,de Castella A,Fitzgerald P,Davis SR

    更新日期:2014-05-01 00:00:00

  • Decreased nocturnal growth hormone secretion and sleep fragmentation in combat-related posttraumatic stress disorder; potential predictors of impaired memory consolidation.

    abstract:BACKGROUND:Healthy sleep facilitates the consolidation of newly acquired memories. Although patients with posttraumatic stress disorder (PTSD) often complain of sleep disturbances and memory deficits, the interrelatedness of these symptoms is not well understood. Sleep may be disturbed in PTSD by increased awakenings d...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.psyneuen.2011.03.009

    authors: van Liempt S,Vermetten E,Lentjes E,Arends J,Westenberg H

    更新日期:2011-10-01 00:00:00

  • Specificity of autobiographical memories and basal cortisol levels in patients with major depression.

    abstract::This study investigated whether over-general retrieval of autobiographical memories in depression is related to increased basal cortisol levels. Forty-seven individuals with a current diagnosis of major depression were given the autobiographical memory test, in which they were asked to produce specific autobiographica...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.psyneuen.2004.11.005

    authors: Barnhofer T,Kuehn EM,de Jong-Meyer R

    更新日期:2005-05-01 00:00:00

  • Animal models for depression and the mismatch hypothesis of disease.

    abstract::Early life stress is one of the best characterized risk factors for psychiatric disorders, including depression, and many animal models have therefore studied the long-term physiological and behavioural consequences of early life stress. In most approaches a very deterministic view of adverse experiences early in life...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.psyneuen.2010.07.001

    authors: Schmidt MV

    更新日期:2011-04-01 00:00:00

  • Digit ratio (2D:4D) and psychopathic traits moderate the effect of exogenous testosterone on socio-cognitive processes in men.

    abstract::Recent evidence suggests that testosterone is negatively correlated with empathic processes in both men and women. Also, administration of testosterone to young women impairs socio-cognitive performance as assessed using the "Reading the Mind in the Eyes Task", especially among those exposed to elevated testosterone c...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2015.08.023

    authors: Carré JM,Ortiz TL,Labine B,Moreau BJ,Viding E,Neumann CS,Goldfarb B

    更新日期:2015-12-01 00:00:00

  • Association between changes in heart rate variability during the anticipation of a stressful situation and the stress-induced cortisol response.

    abstract::Vagal activity - reflecting the activation of stress regulatory mechanisms and prefrontal cortex activation - is thought to play an inhibitory role in the regulation of the hypothalamus-pituitary-adrenal axis. However, most studies investigating the association between stress-induced changes in heart rate variability ...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2018.05.004

    authors: Pulopulos MM,Vanderhasselt MA,De Raedt R

    更新日期:2018-08-01 00:00:00

  • Cortisol increase in empathic stress is modulated by emotional closeness and observation modality.

    abstract::Stress disorders are among the most commonly occurring of all mental disorders. In this context, the question arises whether the stress inevitably unfolding around us has the potential to "contaminate" and compromise us. In the current multi-center study, we investigate the existence of such empathic stress (defined a...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.psyneuen.2014.04.005

    authors: Engert V,Plessow F,Miller R,Kirschbaum C,Singer T

    更新日期:2014-07-01 00:00:00

  • Long term modulation of the HPA axis by the hippocampus. Behavioral, biochemical and immunological endpoints in rats exposed to chronic mild stress.

    abstract::Mature rats were given lesions of the hippocampus (HIPPO), subiculum (SUBIC) or fimbria-fornix (FIFO) and then received the mild chronic stressors of food deprivation and isolation housing for ten months prior to testing. Group differences in circadian activity were investigated along with locomotion elicited by amphe...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/s0306-4530(00)00033-0

    authors: Bratt AM,Kelley SP,Knowles JP,Barrett J,Davis K,Davis M,Mittleman G

    更新日期:2001-02-01 00:00:00

  • Endotoxin elicits ambivalent social behaviors.

    abstract::The acute phase response to infection is reliably accompanied by decreases in social investigation; however, social behavior is commonly assayed in inescapable environments using unfamiliar social stimuli. In this experiment, male Wistar rats were raised from weaning with 2 familiar, same-sex conspecifics. In adulthoo...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2011.11.008

    authors: Yee JR,Prendergast BJ

    更新日期:2012-07-01 00:00:00

  • Maternal prenatal anxiety and downregulation of placental 11β-HSD2.

    abstract:BACKGROUND:Raised maternal anxiety during pregnancy is associated with increased risk of adverse neurodevelopmental outcomes for her child. The mechanisms underlying this are not known but animal studies suggest prenatal stress may alter the function of the placenta. Here we determined whether maternal prenatal anxiety...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2011.09.014

    authors: O'Donnell KJ,Bugge Jensen A,Freeman L,Khalife N,O'Connor TG,Glover V

    更新日期:2012-06-01 00:00:00

  • Optimism and telomere length among African American adults in the Jackson Heart Study.

    abstract:BACKGROUND:Optimism is linked with greater longevity in both White and African American populations. Optimism may enhance longevity by slowing cellular aging, for which leukocyte telomere shortening is a biomarker. However, limited studies have examined the association of optimism with leukocyte telomere length among A...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2020.105124

    authors: Lee HH,Okuzono SS,Kim ES,De Vivo I,Raffield LM,Glover L,Sims M,Grodstein F,Kubzansky LD

    更新日期:2020-12-29 00:00:00

  • For better and worse? The roles of closeness, marital behavior, and age in spouses' cardiometabolic similarity.

    abstract::Spouses share common risks for cardiometabolic diseases: a person's diabetes or hypertension raises the partner's odds of developing the same condition. The mechanisms responsible for this disease concordance remain poorly understood. To examine three factors that may modulate partners' cardiometabolic similarity-clos...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2020.104777

    authors: Wilson SJ,Peng J,Andridge R,Jaremka LM,Fagundes CP,Malarkey WB,Belury MA,Kiecolt-Glaser JK

    更新日期:2020-10-01 00:00:00

  • Increased basal activity of the hypothalamo-pituitary-adrenal axis during pregnancy in rats bred for high anxiety-related behaviour.

    abstract::In order to test the hypothesis that prenatal hormones influence the emotional maturation of the offspring, the hypothalamo-pituitary-adrenal (HPA) axis activity was studied at the end of pregnancy in two rat breeding lines differing consistently in their innate anxiety-related behaviour in the elevated plus-maze. Vir...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/s0306-4530(98)00023-7

    authors: Neumann ID,Wigger A,Liebsch G,Holsboer F,Landgraf R

    更新日期:1998-07-01 00:00:00

  • Gender-affirming hormone treatment and cognitive function in transgender young adults: a systematic review and meta-analysis.

    abstract:BACKGROUND:Previous studies have examined whether steroid hormone treatment in transgender individuals may affect cognitive function; yet, their limited power does not allow firm conclusions to be drawn. We leveraged data from to-date literature aiming to explore the effect of gender-affirming hormone administration on...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.psyneuen.2020.104721

    authors: Karalexi MA,Georgakis MK,Dimitriou NG,Vichos T,Katsimpris A,Petridou ET,Papadopoulos FC

    更新日期:2020-09-01 00:00:00

  • HPA axis programming by maternal undernutrition in the male rat offspring.

    abstract::Epidemiological and experimental studies have demonstrated that perinatal alterations such as maternal undernutrition are frequently associated with the onset of several chronic adult diseases. Although the physiological mechanisms involved in this "fetal programming" remain largely unknown, it has been shown that ear...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.psyneuen.2007.03.014

    authors: Vieau D,Sebaai N,Léonhardt M,Dutriez-Casteloot I,Molendi-Coste O,Laborie C,Breton C,Deloof S,Lesage J

    更新日期:2007-08-01 00:00:00

  • Prenatal and postnatal cortisol and testosterone are related to parental caregiving quality in fathers, but not in mothers.

    abstract::Testosterone and cortisol have both been implicated in human parenting behavior. We investigated the relations between observed quality of caregiving during parent-child interactions and pre- and postnatal testosterone and cortisol levels, in both mothers (N = 88) and fathers (N = 57). Testosterone and cortisol were m...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2018.07.013

    authors: Bos PA,Hechler C,Beijers R,Shinohara K,Esposito G,de Weerth C

    更新日期:2018-11-01 00:00:00

  • Role of apoptosis in the Post-traumatic stress disorder model-single prolonged stressed rats.

    abstract::Post-traumatic stress disorder (PTSD) is a stress-related mental disorder which occurs following exposure to traumatic events. A number of brain neuroimaging studies have revealed that PTSD patients have reduced volume and abnormal functions in the hippocampus and the amygdala. However, the pathogenesis of abnormaliti...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.psyneuen.2018.05.015

    authors: Jia Y,Han Y,Wang X,Han F

    更新日期:2018-09-01 00:00:00

  • PDLIM5 improves depression-like behavior of prenatal stress offspring rats via methylation in male, but not female.

    abstract:OBJECTIVE:Prenatal stress (PS) contributes to depression-like behavior in the offspring. PDLIM5 is involved in the onset of mental disorders. This study is to investigate the role and mechanism of PDLIM5 in depression-like behavior of PS offspring rats. METHODS:PS model was used to analyze the effects of different tre...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2020.104629

    authors: Lu Y,Jiang J,Si J,Wu Q,Tian F,Jiao K,Mu Y,Dong P,Zhu Z

    更新日期:2020-05-01 00:00:00

  • Activation of the hypothalamus-pituitary-adrenal axis by bacterial endotoxins: routes and intermediate signals.

    abstract::Peripheral administration of endotoxin induces brain-mediated responses, including activation of the hypothalamus-pituitary-adrenal (HPA) axis and changes in thermoregulation. This paper reviews the mechanisms by which endotoxin affects these responses. The effects on thermoregulation are complex and include macrophag...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/0306-4530(94)90010-8

    authors: Tilders FJ,DeRijk RH,Van Dam AM,Vincent VA,Schotanus K,Persoons JH

    更新日期:1994-01-01 00:00:00

  • A 3-day estrogen treatment improves prefrontal cortex-dependent cognitive function in postmenopausal women.

    abstract::Estrogen secretion in young women follows a cyclic pattern characterized by a pronounced surge in estrogen around ovulation. The way in which this estrogen peak affects cognitive functioning is unclear. Short-term estrogen treatment for a few days mimicking normal pre-menopausal estrogen dynamics substantially enhance...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2006.05.007

    authors: Krug R,Born J,Rasch B

    更新日期:2006-09-01 00:00:00

  • Endocrine and psychological stress response in simulated doctor-patient interactions in medical education.

    abstract:BACKGROUND:Training of doctor-patient interactions by means of patient actors is considered a useful didactic tool in medical education. However, though students report it as being highly stressful little systematic research has verified this notion. AIMS:To assess the endocrine and psychological stress responses of s...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2018.09.028

    authors: Deinzer R,Kiupel S,Weik U

    更新日期:2019-07-01 00:00:00

  • Short-term transdermal estradiol therapy, cognition and depressive symptoms in healthy older women. A randomised placebo controlled pilot cross-over study.

    abstract::The potential role of estrogen in protecting women from cognitive decline and reducing depressive symptoms is of great therapeutic interest. In a pilot randomised placebo controlled cross-over study, we aimed to determine the short-term effects of transdermal estradiol therapy on cognition and depressive symptoms in h...

    journal_title:Psychoneuroendocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.psyneuen.2004.08.007

    authors: Schiff R,Bulpitt CJ,Wesnes KA,Rajkumar C

    更新日期:2005-05-01 00:00:00

  • The role of inflammation in the association between poverty and working memory in childhood.

    abstract:BACKGROUND:Family financial difficulties have been directly linked to poorer executive functioning in childhood. However, recent studies suggest that difficulties in affording basic items and other necessities may also indirectly affect children's executive functions through several psychological but also physiological...

    journal_title:Psychoneuroendocrinology

    pub_type: 杂志文章

    doi:10.1016/j.psyneuen.2020.105040

    authors: Kokosi T,Flouri E,Midouhas E

    更新日期:2021-01-01 00:00:00