Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review.

Abstract:

:ACTH secretion is primarily controlled by hypothalamic secretion of corticotropin releasing factor (CRF) into pituitary portal blood. However arginine vasopressin (AVP) and oxytocin (OT) can modulate the actions of CRF and at times may be important mediators of stress-induced ACTH secretion. The relative contributions of CRF, AVP, and OT to the control of ACTH secretion vary with different types of stress. In general, AVP stimulates ACTH secretion in all species studied. OT also stimulates ACTH release in rats but is inhibitory in primates. The involvement of AVP and OT in the control of ACTH secretion may have important implications for physiological and pathological conditions associated with activation of the hypothalamo--hypophysial--adrenal cortical axis.

journal_title

Psychoneuroendocrinology

authors

Gibbs DM

doi

10.1016/0306-4530(86)90048-x

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

131-9

issue

2

eissn

0306-4530

issn

1873-3360

journal_volume

11

pub_type

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