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Prolactin response to low-dose haloperidol challenge in schizophrenic, non-schizophrenic psychotic, and control subjects.

Abstract：

:Haloperidol was administered IV to 46 male psychotic inpatients and 28 male control subjects. A two-way analysis of covariance, with age as the covariate, revealed that DSM-III schizophrenics (n = 27) had a lower prolactin response to haloperidol than did the controls (n = 28). There were no significant differences between the prolactin responses in schizophrenics, patients with affective disorders (n = 7), and those with other psychoses (n = 12), which included patients with paranoia, schizophreniform, schizoaffective disorder, and atypical psychoses. These findings support the proposition that tuberoinfundibular dopaminergic dysfunction may occur in certain patients with DSM-III schizophrenia.

journal_name

Psychoneuroendocrinology

journal_title

Psychoneuroendocrinology

authors

Copolov DL,Keks NA,Kulkarni J,Singh BS,McKenzie D,McGorry P,Hill C

doi

10.1016/0306-4530(90)90033-6

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

225-31

issue

3

eissn

0306-4530

issn

1873-3360

journal_volume

15

pub_type

杂志文章

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