Abstract:
:Previous studies have shown that 17beta-estradiol (E2) induces antidepressant-like actions per se and potentiates those produced by fluoxetine (FLX) in the forced swimming test (FST). The aim of the present work was to explore the participation of serotonin 1A receptors (5-HT1A) and estrogen receptors (ERs) in the antidepressant-like actions of E2, FLX or their combination in the FST. Although all antidepressants reduce behavioral immobility, antidepressants that modulate serotonergic neurotransmission increase swimming behavior whereas those that modulate the catecholaminergic neurotransmission increase climbing behavior. Thus, using this animal model, it is possible to infer which neurotransmitter system is modulating the action of an antidepressant compound. Ovariectomized female Wistar rats were used in all experiments. In the first experiment, an effective dose of E2 (10 microg/rat, -48 h) was combined with several doses (0.5, 1.0 and 2 mg/kg) of RU 58668 (a pure ER antagonist) 48 h previous to the FST. The second experiment evaluated the action of (1 mg/kg, -48 h or -23, -5 and -1 h) WAY 100635 (5-HT1A receptor antagonist) on the antidepressant-like action of FLX (10 mg/kg, -23, -5 and -1 h). In the third experiment, the effect of RU 58668 (2 mg/kg, -48) or WAY 100635 (1 mg/kg, -48 h) on the antidepressant-like action of the combination of a sub-optimal dose of E2 (2.5 microg/rat, -48 h) plus a non-effective dose of FLX (2.5 mg/kg, -23,-5 and -1 h) was evaluated. The results showed that RU 58668, the antagonist to the ER, canceled the antidepressant-like action of E2 in a dose-dependent manner. The antagonist to the 5-HT1A receptor blocked the antidepressant action of FLX only when administered simultaneously with FLX, i.e. -23, -5 and -1 h before the FST. Finally, the administration of both RU 58668, and WAY100635 canceled the antidepressant-like action of the combination of E2/FLX. These results imply that both 5-HT1A receptors and ERs participate in the facilitating actions of E2 on the antidepressant-like action of FLX in the FST.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Estrada-Camarena E,López-Rubalcava C,Fernández-Guasti Adoi
10.1016/j.psyneuen.2006.05.001subject
Has Abstractpub_date
2006-09-01 00:00:00pages
905-14issue
8eissn
0306-4530issn
1873-3360pii
S0306-4530(06)00087-4journal_volume
31pub_type
杂志文章abstract::Females begin to demonstrate greater negative affective responses to stress than males in adolescence. This may reflect the concurrent emergence of underlying differences in physiological response systems, including corticolimbic circuitries, the hypothalamic-pituitary-adrenal axis (HPAA), and the autonomic nervous sy...
journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/j.psyneuen.2004.08.004
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.07.009
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/j.psyneuen.2004.11.005
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(93)90004-5
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.09.018
更新日期:2013-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.104791
更新日期:2020-10-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2007.04.004
更新日期:2007-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/s0306-4530(02)00038-0
更新日期:2003-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.03.017
更新日期:2012-11-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2015.08.009
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2015.08.023
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pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,meta分析
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更新日期:2019-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.03.018
更新日期:2016-07-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1016/s0306-4530(01)00036-1
更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.psyneuen.2015.08.019
更新日期:2015-12-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.07.021
更新日期:2012-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.07.016
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